Protein Alignment cad and HOXC8

DIOPT Version :10

• Sequence 1: NP_001260641.1
• Gene: cad / 35341
• FlyBaseID: FBgn0000251
• Length: 445
• Species: Drosophila melanogaster
• Sequence 2: NP_073149.1
• Gene: HOXC8 / 3224
• HGNCID: 5129
• Length: 242
• Species: Homo sapiens
• Alignment Length: 290
• Identity: 81/290 - (27%)
• Similarity: 105/290 - (36%)
• Gaps: 103/290 - (35%)

  Fly    80 AGEWHSPASSTADNFVQNVPTSAHQLMQ---------QHHHHHAHASSSSASSGSSSSGGAPGAP 135
            |||...||.... .|.|:|..| |.|:.         ||..||........:||.|:||     .
Human    15 AGESLEPAYYDC-RFPQSVGRS-HALVYGPGGSAPGFQHASHHVQDFFHHGTSGISNSG-----Y 72

  Fly   136 QLNETNSSIGVGGAGGGGGVGGATDGGPGSAPPNHQQHIAEGLPSPPITVSGSEISSPGAPTSAS 200
            |.|..:.|.. |.|....|.                    |.||...:..:..|.|....|...|
Human    73 QQNPCSLSCH-GDASKFYGY--------------------EALPRQSLYGAQQEASVVQYPDCKS 116

  Fly   201 SPHHHLAHHLSAVANNNNNNN----NNNNSPSTHNNNNNNNSVSNNNRTSPSKPPYFDWMKKPAY 261
            |            ||.|::..    |.|:|||.                      .|.|| :|..
Human   117 S------------ANTNSSEGQGHLNQNSSPSL----------------------MFPWM-RPHA 146

  Fly   262 PAQPQPDLSSSPNLEDLSDLLDASGKTRTKDKYRVVYTDFQRLELEKEYCTSRYITIRRKSELAQ 326
            |.:                   .||        |..|:.:|.||||||:..:.|:|.:|:.|::.
Human   147 PGR-------------------RSG--------RQTYSRYQTLELEKEFLFNPYLTRKRRIEVSH 184

  Fly   327 TLSLSERQVKIWFQNRRAKERKQNKKGSDP 356
            .|.|:||||||||||||.|.:|:|.|...|
Human   185 ALGLTERQVKIWFQNRRMKWKKENNKDKLP 214

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
cad	NP_001260641.1	Homeodomain	293..348	CDD:459649	28/54 (52%)
HOXC8	NP_073149.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	114..154		17/101 (17%)
		Antp-type hexapeptide	138..143		3/5 (60%)
		Homeodomain	150..206	CDD:459649	30/63 (48%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	206..242		4/9 (44%)