Protein Alignment cad and HOXB4

DIOPT Version :10

• Sequence 1: NP_001260641.1
• Gene: cad / 35341
• FlyBaseID: FBgn0000251
• Length: 445
• Species: Drosophila melanogaster
• Sequence 2: NP_076920.1
• Gene: HOXB4 / 3214
• HGNCID: 5115
• Length: 251
• Species: Homo sapiens
• Alignment Length: 198
• Identity: 59/198 - (29%)
• Similarity: 82/198 - (41%)
• Gaps: 62/198 - (31%)

  Fly   163 PGSAPPNHQQHIAEGLPSPP-----ITVSGSEI----SSPGAPTSASSPHHHLAHHLSAVANNNN 218
            |...||.....::...|:||     :...|...    |||..|..|.:|.|
Human    78 PPPPPPPPPPGLSPRAPAPPPAGALLPEPGQRCEAVSSSPPPPPCAQNPLH-------------- 128

  Fly   219 NNNNNNNSPSTHNNNNNNNSVSNNNRTSPSKPPYFDWMKKPAYPAQPQPDLSSSPNLEDLSDLLD 283
                  .|||               .::..:|..:.||:|....       :.:||.
Human   129 ------PSPS---------------HSACKEPVVYPWMRKVHVS-------TVNPNY-------- 157

  Fly   284 ASGKTRTKDKYRVVYTDFQRLELEKEYCTSRYITIRRKSELAQTLSLSERQVKIWFQNRRAKERK 348
            |.|:.:   :.|..||..|.||||||:..:||:|.||:.|:|..|.|||||:||||||||.|.:|
Human   158 AGGEPK---RSRTAYTRQQVLELEKEFHYNRYLTRRRRVEIAHALCLSERQIKIWFQNRRMKWKK 219

  Fly   349 QNK 351
            .:|
Human   220 DHK 222

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
cad	NP_001260641.1	Homeodomain	293..348	CDD:459649	32/54 (59%)
HOXB4	NP_076920.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..134		17/90 (19%)
		Antp-type hexapeptide	141..146		1/4 (25%)
		Homeodomain	163..219	CDD:459649	32/58 (55%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	220..251		1/3 (33%)