Protein Alignment cad and HOXA13

DIOPT Version :10

• Sequence 1: NP_001260641.1
• Gene: cad / 35341
• FlyBaseID: FBgn0000251
• Length: 445
• Species: Drosophila melanogaster
• Sequence 2: NP_000513.2
• Gene: HOXA13 / 3209
• HGNCID: 5102
• Length: 388
• Species: Homo sapiens
• Alignment Length: 367
• Identity: 91/367 - (24%)
• Similarity: 134/367 - (36%)
• Gaps: 100/367 - (27%)

  Fly    54 AAHHAAAAHQMYYNSHHMFHSAAAASAGEWH-----SPASSTADNFVQNVPTSAHQLMQQHHHHH 113
            ||..||||...........|.||||:.|.:.     :.|::.|.|..:|:..           |.
Human    41 AAAAAAAAAAAGAGGGGFPHPAAAAAGGNFSVAAAAAAAAAAAANQCRNLMA-----------HP 94

  Fly   114 AHASSSSASSGSSSSGGAPGAPQLNETNSSIGVGGAGGGGGVGGATDGGPGSAPPNHQQHIAEGL 178
            |..:..:||:.||:.|.||.:     ..::.....|........::.||||.|.|...:...:
Human    95 APLAPGAASAYSSAPGEAPPS-----AAAAAAAAAAAAAAAAAASSSGGPGPAGPAGAEAAKQ-- 152

  Fly   179 PSPPITVSGSEISSPGA-----------PTSASSPHHHLAHHL-----SAVANNNNNNNNNNNSP 227
             ..|.:.:....|.|.|           |.:...||.:.....     :|.|....:...:...|
Human   153 -CSPCSAAAQSSSGPAALPYGYFGSGYYPCARMGPHPNAIKSCAQPASAAAAAAFADKYMDTAGP 216

  Fly   228 STHNNNNNNNSVS--------------------------------NNNRTSPSKPP---YFDW-- 255
            :....::.....:                                ..:|..|...|   |..|
Human   217 AAEEFSSRAKEFAFYHQGYAAGPYHHHQPMPGYLDMPVVPGLGGPGESRHEPLGLPMESYQPWAL 281

  Fly   256 -------MKKPAYPAQPQ-------PDLSSSPNLEDLSDLLDASGKTRTKDKYRVVYTDFQRLEL 306
                   |..|...|||.       ||:.|.|:        |||...|.:.| ||.||..|..||
Human   282 PNGWNGQMYCPKEQAQPPHLWKSTLPDVVSHPS--------DASSYRRGRKK-RVPYTKVQLKEL 337

  Fly   307 EKEYCTSRYITIRRKSELAQTLSLSERQVKIWFQNRRAKERK 348
            |:||.|:::||..::..::.|.:||||||.|||||||.||:|
Human   338 EREYATNKFITKDKRRRISATTNLSERQVTIWFQNRRVKEKK 379

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
cad	NP_001260641.1	Homeodomain	293..348	CDD:459649	30/54 (56%)
HOXA13	NP_000513.2	HoxA13_N	85..224	CDD:463521	28/157 (18%)
		Homeodomain	323..379	CDD:459649	30/56 (54%)