Protein Alignment cad and HOXA10

DIOPT Version :10

• Sequence 1: NP_001260641.1
• Gene: cad / 35341
• FlyBaseID: FBgn0000251
• Length: 445
• Species: Drosophila melanogaster
• Sequence 2: NP_061824.3
• Gene: HOXA10 / 3206
• HGNCID: 5100
• Length: 410
• Species: Homo sapiens
• Alignment Length: 292
• Identity: 78/292 - (26%)
• Similarity: 124/292 - (42%)
• Gaps: 69/292 - (23%)

  Fly    86 PA-SSTADNFVQNVPTSAHQLMQQHHHHHAHASSSSA--------------SSGSSSSGGAPGAP 135
            || .:|:.:|.||:...:...:..........|:::|              :.|:||....||..
Human   150 PAPQATSCSFAQNIKEESSYCLYDSADKCPKVSATAAELAPFPRGPPPDGCALGTSSGVPVPGYF 214

  Fly   136 QLNET-NSSIGVGGAGGGGGVGGATDGGPGSAPPNHQQHIAEGLPSPPITVSGS--------EIS 191
            :|::. .::.|.|..|||....||   ||..|.|.     ..|...||...|||        .:.
Human   215 RLSQAYGTAKGYGSGGGGAQQLGA---GPFPAQPP-----GRGFDLPPALASGSADAARKERALD 271

  Fly   192 SPGAPTSASSPHHHLAHHLSAVANNNNNNNNNNNSPSTHNNNNNNNSVSNNNRTSPSKPPYFDWM 256
            ||..||.|.                 .:...:......|.:::....:|    .:||:
Human   272 SPPPPTLAC-----------------GSGGGSQGDEEAHASSSAAEELS----PAPSE------- 308

  Fly   257 KKPAYPAQPQPDLSSSPNLEDLSDLLDA-SGKTRTKDKYRVVYTDFQRLELEKEYCTSRYITIRR 320
               :..|.|:.|...:...|:.::.|.| ||:     |.|..||..|.||||||:..:.|:|..|
Human   309 ---SSKASPEKDSLGNSKGENAANWLTAKSGR-----KKRCPYTKHQTLELEKEFLFNMYLTRER 365

  Fly   321 KSELAQTLSLSERQVKIWFQNRRAKERKQNKK 352
            :.|:::::.|::|||||||||||.|.:|.|::
Human   366 RLEISRSVHLTDRQVKIWFQNRRMKLKKMNRE 397

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
cad	NP_001260641.1	Homeodomain	293..348	CDD:459649	28/54 (52%)
HOXA10	NP_061824.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	89..158		3/7 (43%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	221..339		34/161 (21%)
		Homeodomain	337..393	CDD:459649	28/60 (47%)