Protein Alignment cad and HMX2

DIOPT Version :10

• Sequence 1: NP_001260641.1
• Gene: cad / 35341
• FlyBaseID: FBgn0000251
• Length: 445
• Species: Drosophila melanogaster
• Sequence 2: NP_005510.1
• Gene: HMX2 / 3167
• HGNCID: 5018
• Length: 273
• Species: Homo sapiens
• Alignment Length: 290
• Identity: 69/290 - (23%)
• Similarity: 100/290 - (34%)
• Gaps: 88/290 - (30%)

  Fly   148 GAGGGGGVGGAT-----DGGPGSAPPNHQQHIAEGLPSPPITVS-GSEISSPG----APTSASSP 202
            |....|||...|     .|||..||..     ..|.|:...::| .||...|.    || :...|
Human    10 GCPAAGGVSSFTIQSILGGGPSEAPRE-----PVGWPARKRSLSVSSEEEEPDDGWKAP-ACFCP 68

  Fly   203 HHHLAHHLSAVANNNNNNNNNNNSPSTH----------NNNNNNNSVSNNNRTSPSKPPYFDWM- 256
            ..|               ......|..|          ...:..:......||....|.:.|:.
Human    69 DQH---------------GPKEQGPKHHPPIPFPCLGTPKGSGGSGPGGLERTPFLSPSHSDFKE 118

  Fly   257 -KKPAYPAQPQPDLSSSPNLEDLSDLLDASGKTR----TKDKYRVVYTDFQRLELEKEYCTSRYI 316
             |:...||.     |.||..|...|    .|..|    .|.|.|.|::..|..:||..:...||:
Human   119 EKERLLPAG-----SPSPGSERPRD----GGAERQAGAAKKKTRTVFSRSQVYQLESTFDMKRYL 174

  Fly   317 TIRRKSELAQTLSLSERQVKIWFQNRRAKERKQNKKGSDPNVMGVGVQHADYSQLLDAKAKLEPG 381
            :...::.||.:|.|:|.|||.||||||.|.::|                        ..|:|| .
Human   175 SSSERACLASSLQLTETQVKTWFQNRRNKWKRQ------------------------LSAELE-A 214

  Fly   382 LHLSHSLAHSMNPM-------AAMNIPAMR 404
            .:::|:.|.::..|       :.:.:|..|
Human   215 ANMAHASAQTLVSMPLVFRDSSLLRVPVPR 244

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
cad	NP_001260641.1	Homeodomain	293..348	CDD:459649	23/54 (43%)
HMX2	NP_005510.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..152		37/171 (22%)
		Homeodomain	150..206	CDD:459649	23/55 (42%)