Protein Alignment cad and HLX

DIOPT Version :10

• Sequence 1: NP_001260641.1
• Gene: cad / 35341
• FlyBaseID: FBgn0000251
• Length: 445
• Species: Drosophila melanogaster
• Sequence 2: NP_068777.1
• Gene: HLX / 3142
• HGNCID: 4978
• Length: 488
• Species: Homo sapiens
• Alignment Length: 438
• Identity: 98/438 - (22%)
• Similarity: 136/438 - (31%)
• Gaps: 163/438 - (37%)

  Fly    11 YTQKHSAANLAYASAAGQPWNWT----------PNYHHTPPNHQFLGDVDS-----SHAAHHAAA 60
            |....|..:.||.|:|| |...:          |::......|..:||:.:     :.|:..|..
Human    10 YASNFSLWSAAYCSSAG-PGGCSFPLDPAAVKKPSFCIADILHAGVGDLGAAPEGLAGASAAALT 73

  Fly    61 AHQMYYNSHHMFHSAAAASAGEWHSPASSTADNFVQNVPTSAHQ----LMQQHHHHHAH------ 115
            ||....:.|..|.:||       .||...|.......||....|    |...:||||..
Human    74 AHLGSVHPHASFQAAA-------RSPLRPTPVVAPSEVPAGFPQRLSPLSAAYHHHHPQQQQQQQ 131

  Fly   116 -------------------ASSSSASSGSSSSGGAPGA------------------PQLNETN-- 141
                               ||.:........||.||..                  |::.|.|
Human   132 QPQQQQPPPPPRAGALQPPASGTRVVPNPHHSGSAPAPSSKDLKFGIDRILSAEFDPKVKEGNTL 196

  Fly   142 ---SSIGVGGAGGGGGVGGATDGGPGSAPPNHQQHIAEGLPSPPITVSGSEISSPGAPTSASSPH 203
               :|:..||...|..:.|        ..|:..|..|.   ..||. ..|.|.||
Human   197 RDLTSLLTGGRPAGVHLSG--------LQPSAGQFFAS---LDPIN-EASAILSP---------- 239

  Fly   204 HHLAHHLSAVANNNNNNNNNNNSPSTHNNNNNNNSVSNN-NRTSPSKPPYFDWMKKPAYPAQPQP 267
                                       .|:|..|||.:. ..|.|.  ||....|
Human   240 ---------------------------LNSNPRNSVQHQFQDTFPG--PYAVLTK---------- 265

  Fly   268 DLSSSPNLEDLSDLLDASGKTRTKDKYRVVYTDFQRLELEKEYCTSRYITIRRKSELAQTLSLSE 332
                        |.:..:.| |.:...|.|:::.||..|||.:...:|:|...:.:||..|.|::
Human   266 ------------DTMPQTYK-RKRSWSRAVFSNLQRKGLEKRFEIQKYVTKPDRKQLAAMLGLTD 317

  Fly   333 RQVKIWFQNRRAKER----------KQNKKGSDPNVMGVGVQHADYSQ 370
            .|||:||||||.|.|          |..:.|..|:   .|...||..|
Human   318 AQVKVWFQNRRMKWRHSKEAQAQKDKDKEAGEKPS---GGAPAADGEQ 362

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
cad	NP_001260641.1	Homeodomain	293..348	CDD:459649	24/64 (38%)
HLX	NP_068777.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	118..173		10/54 (19%)
		Homeodomain	273..333	CDD:459649	25/60 (42%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	331..488		8/35 (23%)