Protein Alignment cad and Pdx1

DIOPT Version :10

• Sequence 1: NP_001260641.1
• Gene: cad / 35341
• FlyBaseID: FBgn0000251
• Length: 445
• Species: Drosophila melanogaster
• Sequence 2: NP_074043.4
• Gene: Pdx1 / 29535
• RGDID: 62387
• Length: 283
• Species: Rattus norvegicus
• Alignment Length: 228
• Identity: 66/228 - (28%)
• Similarity: 88/228 - (38%)
• Gaps: 77/228 - (33%)

  Fly   164 GSAPPNHQQHIAEGLPSPPITVSGS----------EISSPGAPTSASSP-----HHHLAHHLSAV 213
            |..||          |.||...:||          :||....|..|..|     ||||...|...
  Rat    39 GRQPP----------PPPPPQFAGSLGTLEQGSPPDISPYEVPPLADDPAGAHLHHHLPAQLGLA 93

  Fly   214 ANNNNNNNNNNNSPSTHNNNNNNNSVSNNNRTS-PSKPPYFDWMKKP------------AYPAQP 265
                      :..|....|......:...:|.. |     |.|||..            ||.|:|
  Rat    94 ----------HPPPGPFPNGTETGGLEEPSRVHLP-----FPWMKSTKAHAWKSQWAGGAYAAEP 143

  Fly   266 QPDLSSSPNLEDLSDLLDASGKTRTKDKYRVVYTDFQRLELEKEYCTSRYITIRRKSELAQTLSL 330
                             :.:.:|||      .||..|.||||||:..::||:..|:.|||..|:|
  Rat   144 -----------------EENKRTRT------AYTRAQLLELEKEFLFNKYISRPRRVELAVMLNL 185

  Fly   331 SERQVKIWFQNRRAK-ERKQNKKGSDPNVMGVG 362
            :||.:||||||||.| :::::||.|.....|.|
  Rat   186 TERHIKIWFQNRRMKWKKEEDKKRSSGTTSGGG 218

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
cad	NP_001260641.1	Homeodomain	293..348	CDD:459649	28/55 (51%)
Pdx1	NP_074043.4	Transactivation domain	13..73		11/43 (26%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	36..81		13/51 (25%)
		Antp-type hexapeptide	118..123		3/9 (33%)
		Homeodomain	147..203	CDD:459649	31/61 (51%)
		Nuclear localization signal. /evidence=ECO:0000250	197..203		3/5 (60%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	201..283		5/18 (28%)