Protein Alignment cad and EN1

DIOPT Version :10

• Sequence 1: NP_001260641.1
• Gene: cad / 35341
• FlyBaseID: FBgn0000251
• Length: 445
• Species: Drosophila melanogaster
• Sequence 2: NP_001417.3
• Gene: EN1 / 2019
• HGNCID: 3342
• Length: 392
• Species: Homo sapiens
• Alignment Length: 453
• Identity: 108/453 - (23%)
• Similarity: 151/453 - (33%)
• Gaps: 160/453 - (35%)

  Fly    10 PYTQKHSAANLAYASAAG---------------------------QPWNWTP----------NYH 37
            |.:|:.||...|.|:..|                           ||...:|          ::.
Human     8 PKSQRDSALGAAAAATPGGLSLSLSPGASGSSGSGSDGDSVPVSPQPAPPSPPAAPCLPPLAHHP 72

  Fly    38 HTPPNHQFLGDVDSSHAAHHAAAAHQMYYNSHHMFHSAAAASAGEWHSPASSTADNFVQNV--PT 100
            |.||:      .......|.||.|||             ...|.:.|    .|.:.|:.|:  |.
Human    73 HLPPH------PPPPPPQHLAAPAHQ-------------PQPAAQLH----RTTNFFIDNILRPD 114

  Fly   101 SAHQLMQQHHHHHAHASSSSASSGSSSSGGAPGAPQLNETNSSIGVGGAGGGGGV---GGATDGG 162
            ...:..|.                         .|||  ..::...|||||||.|   .|.|..|
Human   115 FGCKKEQP-------------------------PPQL--LVAAAARGGAGGGGRVERDRGQTAAG 152

  Fly   163 -----------PGSA-----------PPNHQQHIAEGLPSPPITVSGSEISSPGAPTSASSPHHH 205
                       ||:|           ||:..|..|.|       ...|:..:|.|..:|::....
Human   153 RDPVHPLGTRAPGAASLLCAPDANCGPPDGSQPAAAG-------AGASKAGNPAAAAAAAAAAVA 210

  Fly   206 LAHHLSAVANNNNNNNNNN---NSPST-------HNN-------NNNNNSVSNNNRTSPSKPPYF 253
            .|...:|...::.....:.   .||..       |.|       :.|...|...:...|...|
Human   211 AAAAAAAAKPSDTGGGGSGGGAGSPGAQGTKYPEHGNPAILLMGSANGGPVVKTDSQQPLVWP-- 273

  Fly   254 DWMKKPAYPAQPQPDLSSSPNLEDLSDLLDASGKTRTKDKY-RVVYTDFQRLELEKEYCTSRYIT 317
            .|:....|..:|    ||.|....|.     ..|...:||. |..:|..|...|:.|:..:||||
Human   274 AWVYCTRYSDRP----SSGPRTRKLK-----KKKNEKEDKRPRTAFTAEQLQRLKAEFQANRYIT 329

  Fly   318 IRRKSELAQTLSLSERQVKIWFQNRRAKERKQN--KKGSDPNVMGVG--------VQHADYSQ 370
            .:|:..|||.|||:|.|:||||||:|||.:|..  |.|...::|..|        ||..|.|:
Human   330 EQRRQTLAQELSLNESQIKIWFQNKRAKIKKATGIKNGLALHLMAQGLYNHSTTTVQDKDESE 392

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
cad	NP_001260641.1	Homeodomain	293..348	CDD:459649	28/55 (51%)
EN1	NP_001417.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..100		20/110 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	132..164		11/31 (35%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	219..251		4/31 (13%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	282..306		8/32 (25%)
		Homeodomain	305..360	CDD:459649	27/54 (50%)
		Engrail_1_C_sig	361..391	CDD:431338	7/29 (24%)