Protein Alignment cad and EMX2

DIOPT Version :10

• Sequence 1: NP_001260641.1
• Gene: cad / 35341
• FlyBaseID: FBgn0000251
• Length: 445
• Species: Drosophila melanogaster
• Sequence 2: NP_004089.1
• Gene: EMX2 / 2018
• HGNCID: 3341
• Length: 252
• Species: Homo sapiens
• Alignment Length: 257
• Identity: 64/257 - (24%)
• Similarity: 101/257 - (39%)
• Gaps: 52/257 - (20%)

  Fly   126 SSSGGAPGAPQLNETNSSIGVGGAGGGGGVGGATDGGPGSAPPNHQQHIAEGLPSPPITVSGSEI 190
            |.:..:|..|.||..:|:   ..|..|.||..           |.....||.:..||
Human    37 SYANSSPINPFLNGFHSA---AAAAAGRGVYS-----------NPDLVFAEAVSHPP-------- 79

  Fly   191 SSPGAPTSASSPHHHLAHHLSAVANNNNNNNNNNNSPSTHNNNNNNNSVSNNNRTSPSKPPYFDW 255
             :|..|.....|.|.||.|               ..||:|    :.:.:..:.:..||  .::.|
Human    80 -NPAVPVHPVPPPHALAAH---------------PLPSSH----SPHPLFASQQRDPS--TFYPW 122

  Fly   256 M-KKPAYPAQPQPDLSSSPNLEDLSDLLDASGKTRTKDKYRVVYTDFQRLELEKEYCTSRYITIR 319
            : .:..|.........:||....|.:.|     .|...:.|..::..|.|.||..:..:.|:...
Human   123 LIHRYRYLGHRFQGNDTSPESFLLHNAL-----ARKPKRIRTAFSPSQLLRLEHAFEKNHYVVGA 182

  Fly   320 RKSELAQTLSLSERQVKIWFQNRRAKERKQ--NKKGSDPNVMGVGVQHADYSQLLDAKAKLE 379
            .:.:||.:|||:|.|||:||||||.|.::|  .::|||......|..|.:..::...:|..|
Human   183 ERKQLAHSLSLTETQVKVWFQNRRTKFKRQKLEEEGSDSQQKKKGTHHINRWRIATKQASPE 244

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
cad	NP_001260641.1	Homeodomain	293..348	CDD:459649	22/54 (41%)
EMX2	NP_004089.1	Homeodomain	155..211	CDD:459649	22/55 (40%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	212..252		8/33 (24%)