Protein Alignment cad and Nkx6-1

DIOPT Version :9

• Sequence 1: NP_001260641.1
• Gene: cad / 35341
• FlyBaseID: FBgn0000251
• Length: 445
• Species: Drosophila melanogaster
• Sequence 2: NP_659204.1
• Gene: Nkx6-1 / 18096
• MGIID: 1206039
• Length: 365
• Species: Mus musculus
• Alignment Length: 307
• Identity: 83/307 - (27%)
• Similarity: 118/307 - (38%)
• Gaps: 77/307 - (25%)

  Fly   121 ASSGSSSSGGAPGAPQLNETNSSIGVGGAGGGGGVG-------GATDGGPGSAPPNHQQHIAEG- 177
            :||.||||..:|..|..:.....:....|||...:|       .||..|...........:|.|
Mouse    49 SSSSSSSSSSSPSPPLGSHNPGGLKPPAAGGLSSLGSPPQQLSAATPHGINDILSRPSMPVASGA 113

  Fly   178 -LPSPPITVSGSEISSPGAPTSASSPHHHLAHHLSAVANNNNNNNNNNNSPSTHNNNNNNNSVSN 241
             |||...:.|.|..||..:.||||:.....|...:|.|          :||:     .....:..
Mouse   114 ALPSASPSGSSSSSSSSASATSASAAAAAAAAAAAAAA----------SSPA-----GLLAGLPR 163

  Fly   242 NNRTSPSKPP---YFDWMKKPA---------YPAQP-----------QPDLSSSPNLEDL----- 278
            .:..||..||   ||    .|:         || :|           .|.:..||...|.
Mouse   164 FSSLSPPPPPPGLYF----SPSAAAVAAVGRYP-KPLAELPGRTPIFWPGVMQSPPWRDARLACT 223

  Fly   279 ----SDLLDASGKTRTKDKYRVVYTDFQRLELEKEYCTSRYITIRRKSELAQTLSLSERQVKIWF 339
                |.|||..||   :...|..::..|...|||.:..::|:....::.||.:|.::|.|||:||
Mouse   224 PHQGSILLDKDGK---RKHTRPTFSGQQIFALEKTFEQTKYLAGPERARLAYSLGMTESQVKVWF 285

  Fly   340 QNRRAKERKQN-------KKGSD---PNVMGVGVQHA---DYSQLLD 373
            ||||.|.||::       ||..|   ..:.|......   ||::.||
Mouse   286 QNRRTKWRKKHAAEMATAKKKQDSETERLKGTSENEEDDDDYNKPLD 332

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
cad	NP_001260641.1	Homeobox	295..347	CDD:278475	20/51 (39%)
Nkx6-1	NP_659204.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	35..136		25/86 (29%)
		Repressor domain. /evidence=ECO:0000250	102..269		44/189 (23%)
		Homeobox	240..293	CDD:278475	20/52 (38%)
		DUF3381	<291..345	CDD:288694	11/42 (26%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	295..365		8/38 (21%)
		Involved in DNA-binding. /evidence=ECO:0000250	307..365		6/26 (23%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0850
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X14
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.810