Protein Alignment cad and DLX5

DIOPT Version :10

• Sequence 1: NP_001260641.1
• Gene: cad / 35341
• FlyBaseID: FBgn0000251
• Length: 445
• Species: Drosophila melanogaster
• Sequence 2: NP_005212.1
• Gene: DLX5 / 1749
• HGNCID: 2918
• Length: 289
• Species: Homo sapiens
• Alignment Length: 314
• Identity: 77/314 - (24%)
• Similarity: 124/314 - (39%)
• Gaps: 84/314 - (26%)

  Fly   165 SAPPNHQQHIAEGLPSPPITVSGSEISSPGA------PTSAS-----SPHHHLAHHLSAVANN-- 216
            ||..:|....:..||....|.|.....:.||      |||||     :|:.:..|.::..|.:
Human    24 SAAMHHPSQESPTLPESSATDSDYYSPTGGAPHGYCSPTSASYGKALNPYQYQYHGVNGSAGSYP 88

  Fly   217 NNNNNNNNNSPSTHNNNNNNNSVSNNNRTSPSKPPYFDWMKKPAYPAQPQPDLSSSPNLEDLSDL 281
            .....:.:.:.|.|......|.|                   |:...||:.:::.       .::
Human    89 AKAYADYSYASSYHQYGGAYNRV-------------------PSATNQPEKEVTE-------PEV 127

  Fly   282 LDASGKTRTKDKYRVVYTDFQRLELEKEYCTSRYITIRRKSELAQTLSLSERQVKIWFQNRRAKE 346
            ...:||.:...|.|.:|:.||...|::.:..::|:.:..::|||.:|.|::.||||||||:|:|.
Human   128 RMVNGKPKKVRKPRTIYSSFQLAALQRRFQKTQYLALPERAELAASLGLTQTQVKIWFQNKRSKI 192

  Fly   347 RKQNKKGSDPNVMGVGVQHADYS------QLLDAKAKLEPGLHLSHSLAHSMNPMAAMNIPAMRL 405
            :|..|.|..|      .:|:..|      ....:.|..|| ...|.||:|
Human   193 KKIMKNGEMP------PEHSPSSSDPMACNSPQSPAVWEP-QGSSRSLSH--------------- 235

  Fly   406 HPHL----------------AAHSHSLAAVAAHSHQLQQQHSAQMSAAAAVGTL 443
            |||.                :|..::.||.:.:|| |....|.|...|.|.|||
Human   236 HPHAHPPTSNQSPASSYLENSASWYTSAASSINSH-LPPPGSLQHPLALASGTL 288

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
cad	NP_001260641.1	Homeodomain	293..348	CDD:459649	22/54 (41%)
DLX5	NP_005212.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..49		7/24 (29%)
		DLL_N	32..118	CDD:463567	19/104 (18%)
		Homeodomain	138..194	CDD:459649	22/55 (40%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	198..251		14/74 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	270..289		9/20 (45%)