Protein Alignment cad and DLX2

DIOPT Version :9

• Sequence 1: NP_001260641.1
• Gene: cad / 35341
• FlyBaseID: FBgn0000251
• Length: 445
• Species: Drosophila melanogaster
• Sequence 2: NP_004396.1
• Gene: DLX2 / 1746
• HGNCID: 2915
• Length: 328
• Species: Homo sapiens
• Alignment Length: 405
• Identity: 93/405 - (22%)
• Similarity: 137/405 - (33%)
• Gaps: 136/405 - (33%)

  Fly    92 DNFVQNVPTSAHQLMQQHHHHHAHASSSSASSGSSSSGG--------APGAPQLNETNSSIGVG- 147
            |:.|.::.::.......:|.|....|...|..|.:||..        :|..|....|:||....
Human     6 DSLVADMHSTQIAASSTYHQHQQPPSGGGAGPGGNSSSSSSLHKPQESPTLPVSTATDSSYYTNQ 70

  Fly   148 --GAGGGGGVGGATDGGPGSAPPNHQQHIAEGLPSPPITVSGS-EISSPGAPTS------ASSPH 203
              .||||||      ||...|.....|:.|.||.:.|.:...| ::....|.||      :|||
Human    71 QHPAGGGGG------GGSPYAHMGSYQYQASGLNNVPYSAKSSYDLGYTAAYTSYAPYGTSSSP- 128

  Fly   204 HHLAHHLSAVANNNNNNNNNNNSPSTHNNNNNNNSVSNNNRTSPSKPPYFDWMKKPAYPAQPQPD 268
                      |||
Human   129 ----------ANN---------------------------------------------------- 131

  Fly   269 LSSSPNLEDLS-DLLDASGKTRTKDKYRVVYTDFQRLELEKEYCTSRYITIRRKSELAQTLSLSE 332
               .|..|||. ::...:||.:...|.|.:|:.||...|::.:..::|:.:..::|||.:|.|::
Human   132 ---EPEKEDLEPEIRIVNGKPKKVRKPRTIYSSFQLAALQRRFQKTQYLALPERAELAASLGLTQ 193

  Fly   333 RQVKIWFQNRRAKERKQNKKGSDPNVM--GVGVQHADYSQLLDAKAKLE------------PGLH 383
            .||||||||||:|.:|..|.|..|:..  |........|..:.|.|..:            ||..
Human   194 TQVKIWFQNRRSKFKKMWKSGEIPSEQHPGASASPPCASPPVSAPASWDFGVPQRMAGGGGPGSG 258

  Fly   384 LSHSLAHSMNPMAAM-----NIP---------------AMRLHPHLAAHSHSLAAVAAHSHQLQQ 428
            .|.:.:...:|.:|.     |.|               |..|||......|       |.|
Human   259 GSGAGSSGSSPSSAASAFLGNYPWYHQTSGSASHLQATAPLLHPTQTPQPH-------HHH---- 312

  Fly   429 QHSAQMSAAAAVGTL 443
            .|.....|..:.||:
Human   313 HHHGGGGAPVSAGTI 327

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
cad	NP_001260641.1	Homeobox	295..347	CDD:278475	22/51 (43%)
DLX2	NP_004396.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	16..81		18/70 (26%)
		DLL_N	51..132	CDD:289198	29/152 (19%)
		Homeobox	155..208	CDD:278475	22/52 (42%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	211..270		10/58 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	300..328		10/39 (26%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0850
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810