Protein Alignment cad and NKX2-6

DIOPT Version :10

• Sequence 1: NP_001260641.1
• Gene: cad / 35341
• FlyBaseID: FBgn0000251
• Length: 445
• Species: Drosophila melanogaster
• Sequence 2: NP_001129743.2
• Gene: NKX2-6 / 137814
• HGNCID: 32940
• Length: 301
• Species: Homo sapiens
• Alignment Length: 313
• Identity: 68/313 - (21%)
• Similarity: 97/313 - (30%)
• Gaps: 108/313 - (34%)

  Fly    85 SPASSTADNFVQNVPTSAHQLMQQHHHHHAHASSSSASSGSSSSG----GAPGAPQLNETNSSIG 145
            ||.:||        |.|...:::........|:|.......|...    .....|:.:|
Human     4 SPVTST--------PFSVKDILRLERERSCPAASPHPRVRKSPENFQYLRMDAEPRGSE------ 54

  Fly   146 VGGAGGGGG----VGGATDGGPGSAPPNHQQHIAEGLPSPPITVSGSEISSPGAPTSASSPHHHL 206
            |..||||||    .|....|||..|               .:.:....:..|....:|:||
Human    55 VHNAGGGGGDRKLDGSEPPGGPCEA---------------VLEMDAERMGEPQPGLNAASP---- 100

  Fly   207 AHHLSAVANNNNNNNNNNNSPSTHNNNNNNNSVSNNNRTSPSKPPYFDWMKKPAYPAQPQPDLSS 271
                         .......|. ....|:.:||.......|
Human   101 -------------LGGGTRVPE-RGVGNSGDSVRGGRSEQP------------------------ 127

  Fly   272 SPNLEDLSDLLDASGKTRTKDKYRVVYTDFQRLELEKEYCTSRYITIRRKSELAQTLSLSERQVK 336
                           |.|.:.|.||:::..|.|.||:.:...||::...:..||..|.|:..|||
Human   128 ---------------KARQRRKPRVLFSQAQVLALERRFKQQRYLSAPEREHLASALQLTSTQVK 177

  Fly   337 IWFQNRRAKERKQNKKGS--------DPNVMGVGVQHADYSQLLDAKAKLEPG 381
            |||||||.|.::|.:..|        .|..:.|.|      .:.|.|..|.||
Human   178 IWFQNRRYKCKRQRQDKSLELAGHPLTPRRVAVPV------LVRDGKPCLGPG 224

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
cad	NP_001260641.1	Homeodomain	293..348	CDD:459649	24/54 (44%)
NKX2-6	NP_001129743.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	22..135		28/190 (15%)
		Homeodomain	133..189	CDD:459649	24/55 (44%)