DRSC/TRiP Functional Genomics Resources

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Protein Alignment cad and Cdx2

DIOPT Version :10

Sequence 1:NP_001260641.1 Gene:cad / 35341 FlyBaseID:FBgn0000251 Length:445 Species:Drosophila melanogaster
Sequence 2:NP_031699.2 Gene:Cdx2 / 12591 MGIID:88361 Length:311 Species:Mus musculus


Alignment Length:297 Identity:114/297 - (38%)
Similarity:137/297 - (46%) Gaps:78/297 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly    71 MFHSAAAASAGEWHSPASSTADNFVQNVPTSAHQLMQQHHHHHAHASSSSASSGSSSSGG----- 130
            |:.|:...|.|...:|     .|||     |..|......:|.|.|::::|:..|:.|.|     
Mouse    13 MYPSSVRHSGGLNLAP-----QNFV-----SPPQYPDYGGYHVAAAAAATANLDSAQSPGPSWPT 67

  Fly   131 APGAPQLNETNSSIGVGGAGGGGGVGGATDGGPGSAPPNHQQHIAEGLPSPPITVSGSEISSPGA 195
            |.||| |.|..:....|||.....|....:||..:|...:                    |||..
Mouse    68 AYGAP-LREDWNGYAPGGAAAANAVAHGLNGGSPAAAMGY--------------------SSPAE 111

  Fly   196 PTSASSPHHHLAHHLSAVANNNNNNNNNNNSPS-------THN-NNNNNNSVSNNNRTSPS--KP 250
            ..:...|||| .||.:|             |||       |.| ......:.:...:.|||  :.
Mouse   112 YHAHHHPHHH-PHHPAA-------------SPSCASGLLQTLNLGPPGPAATAAAEQLSPSGQRR 162

  Fly   251 PYFDWMKKPAYPAQPQPDLSSSPNLEDLSDLLDASGKTRTKDKYRVVYTDFQRLELEKEYCTSRY 315
            ...:||:|||     |..|.|..             ||||||||||||||.||||||||:..|||
Mouse   163 NLCEWMRKPA-----QQSLGSQV-------------KTRTKDKYRVVYTDHQRLELEKEFHFSRY 209

  Fly   316 ITIRRKSELAQTLSLSERQVKIWFQNRRAKERKQNKK 352
            ||||||||||.||.|||||||||||||||||||..||
Mouse   210 ITIRRKSELAATLGLSERQVKIWFQNRRAKERKIKKK 246

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
cadNP_001260641.1 Homeodomain 293..348 CDD:459649 48/54 (89%)
Cdx2NP_031699.2 Caudal_act 13..178 CDD:461413 55/214 (26%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 111..151 12/53 (23%)
Interaction with DNA. /evidence=ECO:0000250|UniProtKB:Q99626 185..215 25/29 (86%)
Homeodomain 187..242 CDD:459649 48/54 (89%)
Interaction with 5-mCpG DNA. /evidence=ECO:0000250|UniProtKB:Q99626 227..241 13/13 (100%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 239..311 6/8 (75%)
4S motif, modulates transactivation activity and protein stability. /evidence=ECO:0000269|PubMed:16027724 281..293
Blue background indicates that the domain is not in the aligned region.

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