Protein Alignment cad and DBX1

DIOPT Version :10

• Sequence 1: NP_001260641.1
• Gene: cad / 35341
• FlyBaseID: FBgn0000251
• Length: 445
• Species: Drosophila melanogaster
• Sequence 2: NP_001025036.2
• Gene: DBX1 / 120237
• HGNCID: 33185
• Length: 343
• Species: Homo sapiens
• Alignment Length: 293
• Identity: 79/293 - (26%)
• Similarity: 110/293 - (37%)
• Gaps: 89/293 - (30%)

  Fly   163 PGSAPPNHQQHIAEGLPSPPITVSGSEISSP-------GAPTSASSPHHH---LAHHLSAVANNN 217
            |.|.|........:|.|:.......|::.||       |:|.:|.||...   |...::|:.
Human    55 PRSVPTASMSPPRQGAPTALTDTGASDLGSPGPGSRRGGSPPTAFSPASETTFLKFGVNAIL--- 116

  Fly   218 NNNNNNNNSPSTHNNNNNNNSVSNNNRTSPSKP---PYFD-----WMKKPAYPAQ----PQPDLS 270
                  ::.|.|..:.....||       |.|.   |||:     :::...:||.    |.|...
Human   117 ------SSGPRTETSPALLQSV-------PPKTFAFPYFEGSFQPFIRSSYFPASSSVVPIPGTF 168

  Fly   271 SSPNLEDLSDLLDASGKTRTKDKYRVVYTDFQRLELEKEYCTSRYITIRRKSELAQTLSLSERQV 335
            |.|        |.|.||.|.....|.|::|.||..|||.:...:||:...:.:||..|.|.:.||
Human   169 SWP--------LAARGKPRRGMLRRAVFSDVQRKALEKMFQKQKYISKPDRKKLAAKLGLKDSQV 225

  Fly   336 KIWFQNRR-----AKERK------------QNKKGSDPNVMGVG--------------------V 363
            ||||||||     :|||:            ..|....|::..||                    .
Human   226 KIWFQNRRMKWRNSKERELLSSGGCREQTLPTKLNPHPDLSDVGQKGPGNEEEEEGPGSPSHRLA 290

  Fly   364 QHA--DYSQLLDAKAKLEPGLHLSHSLAHSMNP 394
            .||  |...|.|.:.   || .|..|.|||.:|
Human   291 YHASSDPQHLRDPRL---PG-PLPPSPAHSSSP 319

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
cad	NP_001260641.1	Homeodomain	293..348	CDD:459649	26/59 (44%)
DBX1	NP_001025036.2	PRK12323	<49..182	CDD:481241	35/150 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	56..100		10/43 (23%)
		Homeodomain	184..238	CDD:459649	24/53 (45%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	240..343		20/84 (24%)