Protein Alignment cad and CDX2

DIOPT Version :10

• Sequence 1: NP_001260641.1
• Gene: cad / 35341
• FlyBaseID: FBgn0000251
• Length: 445
• Species: Drosophila melanogaster
• Sequence 2: XP_011533177.1
• Gene: CDX2 / 1045
• HGNCID: 1806
• Length: 321
• Species: Homo sapiens
• Alignment Length: 303
• Identity: 111/303 - (36%)
• Similarity: 136/303 - (44%)
• Gaps: 81/303 - (26%)

  Fly    71 MFHSAAAASAGEWHSPASSTADNFVQNVPTSAHQLMQQHHHHHAHASSSSASSGSSSSGG----- 130
            |:.|:...|.|...:|     .|||     |..|......:|.|.|::::|:..|:.|.|
Human    13 MYPSSVRHSGGLNLAP-----QNFV-----SPPQYPDYGGYHVAAAAAAAANLDSAQSPGPSWPA 67

  Fly   131 APGAPQLNETNSSIGVGGAGGGGGVG-GATDGGPGSA----------PPNHQQHIAEGLPSPPIT 184
            |.|||...:.|.....|.|.....|. |...|.|.:|          |.:|..|......:.|..
Human    68 AYGAPLREDWNGYAPGGAAAAANAVAHGLNGGSPAAAMGYSSPADYHPHHHPHHHPHHPAAAPSC 132

  Fly   185 VSG-SEISSPGAPTSASSPHHHLAHHLSAVANNNNNNNNNNNSPSTHNNNNNNNSVSNNNRTSPS 248
            .|| .:..:||.|..|::.   .|..||......|
Human   133 ASGLLQTLNPGPPGPAATA---AAEQLSPGGQRRN------------------------------ 164

  Fly   249 KPPYFDWMKKPAYPAQPQPDLSS----SPNLEDLSDLLDASGKTRTKDKYRVVYTDFQRLELEKE 309
               ..:||:|||     |..|.|    ||:         ::.||||||||||||||.||||||||
Human   165 ---LCEWMRKPA-----QQSLGSQALTSPS---------STVKTRTKDKYRVVYTDHQRLELEKE 212

  Fly   310 YCTSRYITIRRKSELAQTLSLSERQVKIWFQNRRAKERKQNKK 352
            :..|||||||||:|||.||.|||||||||||||||||||.|||
Human   213 FHYSRYITIRRKAELAATLGLSERQVKIWFQNRRAKERKINKK 255

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
cad	NP_001260641.1	Homeodomain	293..348	CDD:459649	47/54 (87%)
CDX2	XP_011533177.1	Caudal_act	13..179	CDD:461413	50/216 (23%)
		Homeodomain	196..251	CDD:459649	47/54 (87%)