Protein Alignment cad and CDX1

DIOPT Version :10

• Sequence 1: NP_001260641.1
• Gene: cad / 35341
• FlyBaseID: FBgn0000251
• Length: 445
• Species: Drosophila melanogaster
• Sequence 2: NP_001795.2
• Gene: CDX1 / 1044
• HGNCID: 1805
• Length: 265
• Species: Homo sapiens
• Alignment Length: 254
• Identity: 94/254 - (37%)
• Similarity: 111/254 - (43%)
• Gaps: 88/254 - (34%)

  Fly   132 PGAPQLNETNSSIGVGGAGGGGGVGGATDGGPGSAPPNH-----QQHIAEGLPSPPITVSGSEIS 191
            |..|      :|:|:|....|       ...|..|||.:     ..|: |..|:|| |..|:...
Human    17 PARP------ASLGLGPQAYG-------PPAPPPAPPQYPDFSSYSHV-EPAPAPP-TAWGAPFP 66

  Fly   192 S----------PGAPTSASSPHHHLAHHLSAVANNNNNNNNNNNSPSTHNNNNNNNSVSNNNRTS 246
            :          ||....|:||        :::|.
Human    67 APKDDWAAAYGPGPAAPAASP--------ASLAF------------------------------- 92

  Fly   247 PSKPPYFDWMKKPAYP-----AQP--QPDLSSSPNLEDLSDLL-----------DASGKTRTKDK 293
             ..||.|..:..|..|     |||  .|...|||..:..:...           ..|||||||||
Human    93 -GPPPDFSPVPAPPGPGPGLLAQPLGGPGTPSSPGAQRPTPYEWMRRSVAAGGGGGSGKTRTKDK 156

  Fly   294 YRVVYTDFQRLELEKEYCTSRYITIRRKSELAQTLSLSERQVKIWFQNRRAKERKQNKK 352
            |||||||.||||||||:..|||||||||||||..|.|:|||||||||||||||||.|||
Human   157 YRVVYTDHQRLELEKEFHYSRYITIRRKSELAANLGLTERQVKIWFQNRRAKERKVNKK 215

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
cad	NP_001260641.1	Homeodomain	293..348	CDD:459649	46/54 (85%)
CDX1	NP_001795.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	9..153		39/190 (21%)
		Caudal_act	13..142	CDD:461413	35/179 (20%)
		Homeodomain	156..211	CDD:459649	46/54 (85%)
		Interaction with DNA. /evidence=ECO:0000305|PubMed:28473536	157..178		16/20 (80%)
		Interaction with 5-mCpG DNA. /evidence=ECO:0000305|PubMed:28473536	196..207		10/10 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	207..265		8/9 (89%)