Protein Alignment cad and Hoxb2

DIOPT Version :10

• Sequence 1: NP_001260641.1
• Gene: cad / 35341
• FlyBaseID: FBgn0000251
• Length: 445
• Species: Drosophila melanogaster
• Sequence 2: NP_598793.2
• Gene: Hoxb2 / 103889
• MGIID: 96183
• Length: 354
• Species: Mus musculus
• Alignment Length: 287
• Identity: 80/287 - (27%)
• Similarity: 113/287 - (39%)
• Gaps: 59/287 - (20%)

  Fly   169 NHQQHIAEGLPSPPITVSGSEISS--------PGAPTSASSPHHHLAHHLSAVANNNNNNNNNNN 225
            |.|..:||.|.|.|..:...:.||        |..|...:.|...|.   ::......:.....:
Mouse    13 NSQPSLAECLTSFPAVLETFQTSSIKESTLIPPPPPLEQTFPSLQLG---ASTLQRPGSQKQAGD 74

  Fly   226 SPSTHNNNNNNNSVSNNNRTSPSKP-----PYFDWM------KKPAY-PAQPQPDLSS------- 271
            .|:.              |:.|..|     |.|.||      |||:. .|.|.|..||
Mouse    75 GPAL--------------RSPPPLPVAPPAPEFPWMKEKKSTKKPSQSAASPSPAASSVRASEVG 125

  Fly   272 ----SPNLEDLSDLLDASGKTRTKDKYRVVYTDFQRLELEKEYCTSRYITIRRKSELAQTLSLSE 332
                .|.|.:..    .||..|    .|..||:.|.||||||:..::|:...|:.|:|..|.|:|
Mouse   126 SPSDGPGLPECG----GSGSRR----LRTAYTNTQLLELEKEFHFNKYLCRPRRVEIAALLDLTE 182

  Fly   333 RQVKIWFQNRRAKERKQNKKGSDPNVMGVGVQHADYSQLLDAKAKLEPGLHLSHSLAHS-MNPMA 396
            ||||:||||||.|.::|.:....|.....|....|.:.....:..:.||...:|.|..: .:|..
Mouse   183 RQVKVWFQNRRMKHKRQTQHREPPEGEPGGPSAQDDAGEPAEEPTVSPGDVATHRLREACFHPAE 247

  Fly   397 AMNIPAMRLHPHLAAHSHSLAAVAAHS 423
            |...|  |..|..|..:.:|.:|.|.|
Mouse   248 AAQGP--RGAPPSALPATTLESVGASS 272

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
cad	NP_001260641.1	Homeodomain	293..348	CDD:459649	28/54 (52%)
Hoxb2	NP_598793.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	39..143		24/124 (19%)
		Antp-type hexapeptide	92..97		2/4 (50%)
		Homeodomain	142..198	CDD:459649	29/59 (49%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	193..231		6/37 (16%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	246..295		9/29 (31%)