DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment dia and FMNL3

DIOPT Version :9

Sequence 1:NP_001246113.1 Gene:dia / 35340 FlyBaseID:FBgn0011202 Length:1098 Species:Drosophila melanogaster
Sequence 2:XP_011537270.1 Gene:FMNL3 / 91010 HGNCID:23698 Length:1047 Species:Homo sapiens


Alignment Length:1086 Identity:277/1086 - (25%)
Similarity:463/1086 - (42%) Gaps:255/1086 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly    85 MNIPKDKREPLLAKSKEERQKMIMWHLKGKNSLERSANSRFE---KPIDYVEYLQN--GEHSTHK 144
            ||:|.||...|.....|::..:|            ....||:   .|..|::.||:  ....|.|
Human    64 MNLPPDKARLLRQYDNEKKWDLI------------CDQERFQVKNPPHTYIQKLQSFLDPSVTRK 116

  Fly   145 VY--------QCVESLRVALTSNPISWIKE------------------------FGVAGI----- 172
            .:        :.:..|.::|.:|.|.|::|                        |...|:     
Human   117 KFRRRVQESTKVLRELEISLRTNHIGWVREFLNDENKGLDVLVDYLSFAQCSVMFDFEGLESGDD 181

  Fly   173 GTIEKL-----------------------LARS-----------------KNN--ASYEKIEFEA 195
            |..:||                       ||||                 ||:  .|.:......
Human   182 GAFDKLRSWSRSIEDLQPPSALSAPFTNSLARSARQSVLRYSTLPGRRALKNSRLVSQKDDVHVC 246

  Fly   196 IRCLKAIMNNTWGLNVVLNPDQHSVVLLLAQSLDPRKPQTMCEALKLLASFCIVYERNGYEKVLR 260
            |.||:||||..:|.|:|:: ..|: |..:|.||:.:.|:|....|:|||:.|:|  |.|:|.:|.
Human   247 ILCLRAIMNYQYGFNLVMS-HPHA-VNEIALSLNNKNPRTKALVLELLAAVCLV--RGGHEIILA 307

  Fly   261 AITTIAATSFKASERFRPIVDALFASDQQDPKRDLACHSLIFINTLTNTPTDLNFRLHLRCEIMR 325
            |........ |...||..::: .|.::..:....:||  :.|||.:.::..|:|||:||:.|..:
Human   308 AFDNFKEVC-KELHRFEKLME-YFRNEDSNIDFMVAC--MQFINIVVHSVEDMNFRVHLQYEFTK 368

  Fly   326 MGLYDRLDEFTKIVEASNNENLQQHFKIFNEIREDDFEEFVQRFDNVTFNMDDATDCFDVLKNLV 390
            :|    |:||.:....:.:|.||...:.:              .|||          ||| ..|:
Human   369 LG----LEEFLQKSRHTESEKLQVQIQAY--------------LDNV----------FDV-GGLL 404

  Fly   391 TDTTSEPYFLSILQHLLYIRDDFYFRPAYYQLIEECISQIVFHKGYCDPNFENRNFNIDTSLLLD 455
            .|..::...|..::.|                 ||.:|.:.  :...|  .||.|. :..:.|..
Human   405 EDAETKNVALEKVEEL-----------------EEHVSHLT--EKLLD--LENENM-MRVAELEK 447

  Fly   456 DIVEKAKAKESKRSEEYEKKIEQLES------AKQEAEAKAAHLEEKVKLME---ANGVAAPSPN 511
            .::::.|..||.: |.||....|:.:      .|:||..:..|||..|:.:|   :..:|...|.
Human   448 QLLQREKELESIK-ETYENTSHQVHTLRRLIKEKEEAFQRRCHLEPNVRGLESVDSEALARVGPA 511

  Fly   512 KLPKVNIPMPPPPPGGGGAPPPPPPPMPGRAGGGPPPPPPPPMPGRAGGPPPPPPPPGMGGPPPP 576
            :|.:   .|||.........|||...:|      .||||.||:|     |||||.|...  ||.|
Human   512 ELSE---GMPPSDLDLLAPAPPPEEVLP------LPPPPAPPLP-----PPPPPLPDKC--PPAP 560

  Fly   577 PMPGMMRPGGGPPPPPMMMGPMVPVLPHGLKPKKKWDVKNPMKRA------NWKAIVPAKMSDKA 635
            |:||              ..|.| ||..||...:   :|.|:|..      ||.|:.|.::|...
Human   561 PLPG--------------AAPSV-VLTVGLSAIR---IKKPIKTKFRLPVFNWTALKPNQISGTV 607

  Fly   636 FWVKCQEDKLAQDDFLAELAVKFSSKPVKKEQKDAVD----KPTTLTKKNVDLRVLDSKTAQNLA 696
            | .:..::|:.:|..|.:....|.:    |.|..|:|    |..|..|....:.:|::..|:|||
Human   608 F-SELDDEKILEDLDLDKFEELFKT----KAQGPALDLICSKNKTAQKAASKVTLLEANRAKNLA 667

  Fly   697 IMLGGSLKHLSYEQIKICLLRCDTDILSSNILQQLIQYLPPPEHLKRLQEIKAKGEPLPPI---E 758
            |.|..:.:  |.|:|...:...|...|..:.::.|:::||....:|.|::.:.:.:||..:   :
Human   668 ITLRKAGR--SAEEICRAIHTFDLQTLPVDFVECLMRFLPTEAEVKLLRQYERERQPLEELAAED 730

  Fly   759 QFAATIGEIKRLSPRLHNLNFKLTYADMVQDIKPDIVAGTAACEEIRNSKKFSKILELILLLGNY 823
            :|.....:::||:.|:..:.|...:.|.:|.:.|.:.|..||...:::|:|..::||:||.||||
Human   731 RFMLLFSKVERLTQRMAGMAFLGNFQDNLQMLTPQLNAIIAASASVKSSQKLKQMLEIILALGNY 795

  Fly   824 MNSGSKNEAAFGFEISYLTKLSNTKDADNKQTLLHYLADLVEKKFPDALNFYDDLSHVNKASRVN 888
            ||| ||..|.:||::..|..|.:||..|.|.||||::|..|::|:||..||:.:|..|.||:.|:
Human   796 MNS-SKRGAVYGFKLQSLDLLLDTKSTDRKMTLLHFIALTVKEKYPDLANFWHELHFVEKAAAVS 859

  Fly   889 MDAIQKAMRQMNSAVKNL--ETDLQNNKVPQCDDDKFSEVMGKFAEECRQQVDVLGKMQLQMEKL 951
            ::.:...::::...::.:  |..:.:|           .|:..|......::|.|.:.....|:.
Human   860 LENVLLDVKELGRGMELIRRECSIHDN-----------SVLRNFLSTNEGKLDKLQRDAKTAEEA 913

  Fly   952 YKDLSEYYAFDPSKYTMEEFFADIKTFKDAFQAAHNDNVRVREELEKKRRLQEAREQSAREQQER 1016
            |..:..|:...|.......||.....|           :|..:|.|::...::.:|:..||:|..
Human   914 YNAVVRYFGESPKTTPPSVFFPVFVRF-----------IRSYKEAEQENEARKKQEEVMREKQLA 967

  Fly  1017 QQRKKAVVDMDAP-QTQEGVMDSLLEALQTGSAFGQRNRQARRQRP 1061
            |:.||  :|...| |..:.....|:..|        |.|||:..||
Human   968 QEAKK--LDAKTPSQRNKWQQQELIAEL--------RRRQAKEHRP 1003

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
diaNP_001246113.1 Drf_GBD 66..248 CDD:283920 55/246 (22%)
Drf_FH3 253..453 CDD:283917 44/199 (22%)
FH2 608..983 CDD:280362 103/389 (26%)
FMNL3XP_011537270.1 Drf_GBD 64..297 CDD:283920 55/246 (22%)
Drf_FH3 300..497 CDD:283917 59/252 (23%)
FH2 580..945 CDD:280362 104/394 (26%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000085
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R3069
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.940

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