Protein Alignment dia and FMNL3

DIOPT Version :10

• Sequence 1: NP_001246113.1
• Gene: dia / 35340
• FlyBaseID: FBgn0011202
• Length: 1098
• Species: Drosophila melanogaster
• Sequence 2: XP_011537270.1
• Gene: FMNL3 / 91010
• HGNCID: 23698
• Length: 1047
• Species: Homo sapiens
• Alignment Length: 1086
• Identity: 277/1086 - (25%)
• Similarity: 463/1086 - (42%)
• Gaps: 255/1086 - (23%)

  Fly    85 MNIPKDKREPLLAKSKEERQKMIMWHLKGKNSLERSANSRFE---KPIDYVEYLQN--GEHSTHK 144
            ||:|.||...|.....|::..:|            ....||:   .|..|::.||:  ....|.|
Human    64 MNLPPDKARLLRQYDNEKKWDLI------------CDQERFQVKNPPHTYIQKLQSFLDPSVTRK 116

  Fly   145 VY--------QCVESLRVALTSNPISWIKE------------------------FGVAGI----- 172
            .:        :.:..|.::|.:|.|.|::|                        |...|:
Human   117 KFRRRVQESTKVLRELEISLRTNHIGWVREFLNDENKGLDVLVDYLSFAQCSVMFDFEGLESGDD 181

  Fly   173 GTIEKL-----------------------LARS-----------------KNN--ASYEKIEFEA 195
            |..:||                       ||||                 ||:  .|.:......
Human   182 GAFDKLRSWSRSIEDLQPPSALSAPFTNSLARSARQSVLRYSTLPGRRALKNSRLVSQKDDVHVC 246

  Fly   196 IRCLKAIMNNTWGLNVVLNPDQHSVVLLLAQSLDPRKPQTMCEALKLLASFCIVYERNGYEKVLR 260
            |.||:||||..:|.|:|:: ..|: |..:|.||:.:.|:|....|:|||:.|:|  |.|:|.:|.
Human   247 ILCLRAIMNYQYGFNLVMS-HPHA-VNEIALSLNNKNPRTKALVLELLAAVCLV--RGGHEIILA 307

  Fly   261 AITTIAATSFKASERFRPIVDALFASDQQDPKRDLACHSLIFINTLTNTPTDLNFRLHLRCEIMR 325
            |........ |...||..::: .|.::..:....:||  :.|||.:.::..|:|||:||:.|..:
Human   308 AFDNFKEVC-KELHRFEKLME-YFRNEDSNIDFMVAC--MQFINIVVHSVEDMNFRVHLQYEFTK 368

  Fly   326 MGLYDRLDEFTKIVEASNNENLQQHFKIFNEIREDDFEEFVQRFDNVTFNMDDATDCFDVLKNLV 390
            :|    |:||.:....:.:|.||...:.:              .|||          ||| ..|:
Human   369 LG----LEEFLQKSRHTESEKLQVQIQAY--------------LDNV----------FDV-GGLL 404

  Fly   391 TDTTSEPYFLSILQHLLYIRDDFYFRPAYYQLIEECISQIVFHKGYCDPNFENRNFNIDTSLLLD 455
            .|..::...|..::.|                 ||.:|.:.  :...|  .||.|. :..:.|..
Human   405 EDAETKNVALEKVEEL-----------------EEHVSHLT--EKLLD--LENENM-MRVAELEK 447

  Fly   456 DIVEKAKAKESKRSEEYEKKIEQLES------AKQEAEAKAAHLEEKVKLME---ANGVAAPSPN 511
            .::::.|..||.: |.||....|:.:      .|:||..:..|||..|:.:|   :..:|...|.
Human   448 QLLQREKELESIK-ETYENTSHQVHTLRRLIKEKEEAFQRRCHLEPNVRGLESVDSEALARVGPA 511

  Fly   512 KLPKVNIPMPPPPPGGGGAPPPPPPPMPGRAGGGPPPPPPPPMPGRAGGPPPPPPPPGMGGPPPP 576
            :|.:   .|||.........|||...:|      .||||.||:|     |||||.|...  ||.|
Human   512 ELSE---GMPPSDLDLLAPAPPPEEVLP------LPPPPAPPLP-----PPPPPLPDKC--PPAP 560

  Fly   577 PMPGMMRPGGGPPPPPMMMGPMVPVLPHGLKPKKKWDVKNPMKRA------NWKAIVPAKMSDKA 635
            |:||              ..|.| ||..||...:   :|.|:|..      ||.|:.|.::|...
Human   561 PLPG--------------AAPSV-VLTVGLSAIR---IKKPIKTKFRLPVFNWTALKPNQISGTV 607

  Fly   636 FWVKCQEDKLAQDDFLAELAVKFSSKPVKKEQKDAVD----KPTTLTKKNVDLRVLDSKTAQNLA 696
            | .:..::|:.:|..|.:....|.:    |.|..|:|    |..|..|....:.:|::..|:|||
Human   608 F-SELDDEKILEDLDLDKFEELFKT----KAQGPALDLICSKNKTAQKAASKVTLLEANRAKNLA 667

  Fly   697 IMLGGSLKHLSYEQIKICLLRCDTDILSSNILQQLIQYLPPPEHLKRLQEIKAKGEPLPPI---E 758
            |.|..:.:  |.|:|...:...|...|..:.::.|:::||....:|.|::.:.:.:||..:   :
Human   668 ITLRKAGR--SAEEICRAIHTFDLQTLPVDFVECLMRFLPTEAEVKLLRQYERERQPLEELAAED 730

  Fly   759 QFAATIGEIKRLSPRLHNLNFKLTYADMVQDIKPDIVAGTAACEEIRNSKKFSKILELILLLGNY 823
            :|.....:::||:.|:..:.|...:.|.:|.:.|.:.|..||...:::|:|..::||:||.||||
Human   731 RFMLLFSKVERLTQRMAGMAFLGNFQDNLQMLTPQLNAIIAASASVKSSQKLKQMLEIILALGNY 795

  Fly   824 MNSGSKNEAAFGFEISYLTKLSNTKDADNKQTLLHYLADLVEKKFPDALNFYDDLSHVNKASRVN 888
            ||| ||..|.:||::..|..|.:||..|.|.||||::|..|::|:||..||:.:|..|.||:.|:
Human   796 MNS-SKRGAVYGFKLQSLDLLLDTKSTDRKMTLLHFIALTVKEKYPDLANFWHELHFVEKAAAVS 859

  Fly   889 MDAIQKAMRQMNSAVKNL--ETDLQNNKVPQCDDDKFSEVMGKFAEECRQQVDVLGKMQLQMEKL 951
            ::.:...::::...::.:  |..:.:|           .|:..|......::|.|.:.....|:.
Human   860 LENVLLDVKELGRGMELIRRECSIHDN-----------SVLRNFLSTNEGKLDKLQRDAKTAEEA 913

  Fly   952 YKDLSEYYAFDPSKYTMEEFFADIKTFKDAFQAAHNDNVRVREELEKKRRLQEAREQSAREQQER 1016
            |..:..|:...|.......||.....|           :|..:|.|::...::.:|:..||:|..
Human   914 YNAVVRYFGESPKTTPPSVFFPVFVRF-----------IRSYKEAEQENEARKKQEEVMREKQLA 967

  Fly  1017 QQRKKAVVDMDAP-QTQEGVMDSLLEALQTGSAFGQRNRQARRQRP 1061
            |:.||  :|...| |..:.....|:..|        |.|||:..||
Human   968 QEAKK--LDAKTPSQRNKWQQQELIAEL--------RRRQAKEHRP 1003

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
dia	NP_001246113.1	Drf_GBD	66..248	CDD:461886	55/246 (22%)
		Drf_FH3	253..453	CDD:461885	44/199 (22%)
		FH2	608..983	CDD:396655	103/389 (26%)
FMNL3	XP_011537270.1	Drf_GBD	64..297	CDD:461886	55/246 (22%)
		Drf_FH3	300..497	CDD:461885	59/252 (23%)
		FH2	580..945	CDD:396655	104/394 (26%)