DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dia and BNI1

DIOPT Version :9

Sequence 1:	NP_001246113.1	Gene:	dia / 35340	FlyBaseID:	FBgn0011202	Length:	1098	Species:	Drosophila melanogaster
Sequence 2:	NP_014128.2	Gene:	BNI1 / 855450	SGDID:	S000005215	Length:	1953	Species:	Saccharomyces cerevisiae

Alignment Length:	1291	Identity:	276/1291 - (21%)
Similarity:	459/1291 - (35%)	Gaps:	400/1291 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 DSLFGRPSKSKGGTISSGTL---AHGGRPVSADNYVVPGVEDFEQYIQQLSVAELDAKFLEIIED 84
            |||..:.||::.|.:  |.|   .|....:.|.|         ::.:|||. |||        |:
Yeast   739 DSLSEKLSKAEHGLV--GQLEDELHERDRILAKN---------QRVMQQLE-AEL--------EE 783

  Fly    85 MNIPKDKREPLLAKSKEERQKMIMWHL------------KGKNSLERSANSRFEKPIDYVEYLQN 137
            :     |::.||.|.::|.:...|..:            :|...:..|.||..:..|..|  ||:
Yeast   784 L-----KKKHLLEKHQQEVELRKMLTILNSRPEESFNKNEGTRGMNSSLNSSEKANIQKV--LQD 841

  Fly   138 GEHSTHKVYQCVESLRVALTSNPISWIKEFGVAGIGTIEKLLARSKNNASYEK--------IEFE 194
            |.....|.|: .:|.:..:|..|...:            |:|.....|...|.        .|||
Yeast   842 GLSRAKKDYK-DDSKKFGMTLQPNKRL------------KMLRMQMENIENEARQLEMTNFAEFE 893

  Fly   195 AIRCLKAIMNNTWGLNVVLNPDQHSVVLLLAQSLDPRKPQTMCEALKLLASFCIVYERNGYEKVL 259
            ..|....|......:..:.|.|:..:|          |||   ||           :.|....:.
Yeast   894 KDRLEPPIHIKKPKVKKMKNKDRKPLV----------KPQ---EA-----------DVNKLNDLR 934

  Fly   260 RAITTIAATS-----FKASERFRPIVDALFASDQQDPKRDLACHSLIFINTL------------- 306
            ||:..|...|     |...||    |:.||     :.|:.||...|..:.|.
Yeast   935 RALAEIQMESNDISKFNVEER----VNELF-----NEKKSLALKRLKELETKYKGFGIDFNVDEI 990

  Fly   307 ----------TNTPTDLNFRLHLRCEIMRMGLYDRLDEFTKIVEA-------------------- 341
                      ..|..|.|:     ..:.......:|||..:|.:.
Yeast   991 MDSPKKNTGDVETEEDANY-----ASLDPKTYQKKLDEINRITDQLLDIQTQTEHEIQVEEDGES 1050

  Fly   342 --------SNNENLQQHFKIFNEIREDDFE--------EFV----QRF---DNVT----FNMDDA 379
                    ..:|.:.|......|:|.:..|        .|:    |::   .|||    |..::.
Yeast  1051 DLSSSSSDDESEEIYQDASPTQELRSEHSELSSGSGPGSFLDALSQKYGTGQNVTASAAFGENNN 1115

  Fly   380 TDCFDVLKNLVTDT----------TSEPYFLSILQHLLYIRDDFYFRPAYYQLIEECISQIVFHK 434
            ......|.:.|..|          :|.||                        :||...::
Yeast  1116 GSGIGPLHSKVEKTFMNRLRKSTVSSAPY------------------------LEELTQKV---- 1152

  Fly   435 GYCDPNFENRNFNIDTSLLLDDIVEKAKAKESKRSEEYEKKIEQ-LESAKQ-----EAEAKAAHL 493
            ...:|..:|.:..:|..    .:.|.:.|..:...::.||.:.| :|:.||     ..|.|.|..
Yeast  1153 NKVEPYEQNEDEGLDKK----SLPENSTASAASAFDKAEKDMRQHVENGKQGRVVNHEEDKTADF 1213

  Fly   494 EEKVKLMEANGVAAPSPNKLPKVNIPMPPPPPGGGGAPPPPPPPMPGR----------------- 541
            ....||...:|....|...    ::....|||     |||||||:|.:
Yeast  1214 SAVSKLNNTDGAEDLSTQS----SVLSSQPPP-----PPPPPPPVPAKLFGESLEKEKKSEDDTV 1269

  Fly   542 ----AGGGPPPPPPPPMPGRAGGPPPPPPPPGMGG------PPPPPMPGMM---RPGGGPPPPPM 593
                .|..|.|||||        |||||||..:.|      |||||:|.::   ..|..||.|||
Yeast  1270 KQETTGDSPAPPPPP--------PPPPPPPMALFGKPKGETPPPPPLPSVLSSSTDGVIPPAPPM 1326

  Fly   594 MMGPMV------PVLPHG-------LKPKKKWDVKNPMKRANWKAIVPAKMSDKAFWVKCQEDKL 645
            |....:      |:||..       .:|.||      :|:.:|:.:   ..:|.:.|...:.:|.
Yeast  1327 MPASQIKSAVTSPLLPQSPSLFEKYPRPHKK------LKQLHWEKL---DCTDNSIWGTGKAEKF 1382

  Fly   646 AQDDF----LAELAVKFSSKPVK---KEQKDAVDKPTTLTKKNVDLRVLDSKTAQNLAIMLGGSL 703
            |.|.:    ||:|...|:::.:|   .::|:.:.|.|.|::   |:       :|...|.|
Yeast  1383 ADDLYEKGVLADLEKAFAAREIKSLASKRKEDLQKITFLSR---DI-------SQQFGINL---- 1433

  Fly   704 KHLSYEQIKIC-----LLRCDTDIL-----------------SSNILQQLIQYLPPPEHLKRLQE 746
             |: |..:.:.     :|.||.|.|                 |.|:.:....|....|.::.|::
Yeast  1434 -HM-YSSLSVADLVKKILNCDRDFLQTPSVVEFLSKSEIIEVSVNLARNYAPYSTDWEGVRNLED 1496

  Fly   747 IKAKGEPLPPIEQFAATIGEIKRL---------------SPRLHNLNFKLTYADMVQDIKPDIVA 796
            .|      ||.:.    ..:::|.               ..|:..|....:|.....::...:..
Yeast  1497 AK------PPEKD----PNDLQRADQIYLQLMVNLESYWGSRMRALTVVTSYEREYNELLAKLRK 1551

  Fly   797 GTAACEEIRNSKKFSKILELILLLGNYMNSGSKNEAAFGFEISYLTKLSNTKDADNKQTLLHYLA 861
            ...|...::.|.....:..:||.:||:||..||.  |.||::|.|.:|:..||..|..|.|:|:.
Yeast  1552 VDKAVSALQESDNLRNVFNVILAVGNFMNDTSKQ--AQGFKLSTLQRLTFIKDTTNSMTFLNYVE 1614

  Fly   862 DLVEKKFPDALNFYDDLSHVNKASRVNMDAIQKAMRQMNSAVKNLETDLQNNKVPQCDDDKF--- 923
            .:|...:|...:|..:|..|....:|:::.:....:..:.::.|:|..::...:  .|..||
Yeast  1615 KIVRLNYPSFNDFLSELEPVLDVVKVSIEQLVNDCKDFSQSIVNVERSVEIGNL--SDSSKFHPL 1677

  Fly   924 SEVMGK---FAEECRQQVDVL-GKMQLQMEKLYKDLSEYYAFDP-SKYTMEEFFADIKTFKDAFQ 983
            .:|:.|   ...|.|::.|:| .:::|.:.: ::.|...|..|. .|:....||.....|.:.::
Yeast  1678 DKVLIKTLPVLPEARKKGDLLEDEVKLTIME-FESLMHTYGEDSGDKFAKISFFKKFADFINEYK 1741

  Fly   984 AAHNDNVRVREELEKKRRLQEAREQSAREQQERQQRKKAVVDMDAPQTQEG-----------VMD 1037
            .|...|:...||    .||....::...|||:|.|.|:...:.....:.||           |||
Yeast  1742 KAQAQNLAAEEE----ERLYIKHKKIVEEQQKRAQEKEKQKENSNSPSSEGNEEDEAEDRRAVMD 1802

  Fly  1038 SLLEALQTGSAFGQRNRQARRQRPAGAERRAQLSRSRSRTRVTNGQLMTREMILNE 1093
            .|||.|        :|....:..|:.|.:|| |.|.:..:...|...:..::...|
Yeast  1803 KLLEQL--------KNAGPAKSDPSSARKRA-LVRKKYLSEKDNAPQLLNDLDTEE 1849

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dia	NP_001246113.1	Drf_GBD	66..248	CDD:283920	44/201 (22%)
		Drf_FH3	253..453	CDD:283917	45/284 (16%)
		FH2	608..983	CDD:280362	89/426 (21%)
BNI1	NP_014128.2	Drf_GBD	178..458	CDD:399398
		Drf_FH3	511..707	CDD:368862
		Smc	<703..979	CDD:224117	71/312 (23%)
		FH2	1348..1741	CDD:396655	89/432 (21%)
		PTZ00121	<1739..1841	CDD:173412	29/114 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157345443
Domainoid	1	1.000	88	1.000	Domainoid score	I1818
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000085
OrthoInspector	1	1.000	-	-		mtm9222
orthoMCL	1	0.900	-	-		OOG6_101727
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3069
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.770