Protein Alignment dia and BNI1

DIOPT Version :10

• Sequence 1: NP_001246113.1
• Gene: dia / 35340
• FlyBaseID: FBgn0011202
• Length: 1098
• Species: Drosophila melanogaster
• Sequence 2: NP_014128.2
• Gene: BNI1 / 855450
• SGDID: S000005215
• Length: 1953
• Species: Saccharomyces cerevisiae
• Alignment Length: 1291
• Identity: 276/1291 - (21%)
• Similarity: 459/1291 - (35%)
• Gaps: 400/1291 - (30%)

  Fly    23 DSLFGRPSKSKGGTISSGTL---AHGGRPVSADNYVVPGVEDFEQYIQQLSVAELDAKFLEIIED 84
            |||..:.||::.|.:  |.|   .|....:.|.|         ::.:|||. |||        |:
Yeast   739 DSLSEKLSKAEHGLV--GQLEDELHERDRILAKN---------QRVMQQLE-AEL--------EE 783

  Fly    85 MNIPKDKREPLLAKSKEERQKMIMWHL------------KGKNSLERSANSRFEKPIDYVEYLQN 137
            :     |::.||.|.::|.:...|..:            :|...:..|.||..:..|..|  ||:
Yeast   784 L-----KKKHLLEKHQQEVELRKMLTILNSRPEESFNKNEGTRGMNSSLNSSEKANIQKV--LQD 841

  Fly   138 GEHSTHKVYQCVESLRVALTSNPISWIKEFGVAGIGTIEKLLARSKNNASYEK--------IEFE 194
            |.....|.|: .:|.:..:|..|...:            |:|.....|...|.        .|||
Yeast   842 GLSRAKKDYK-DDSKKFGMTLQPNKRL------------KMLRMQMENIENEARQLEMTNFAEFE 893

  Fly   195 AIRCLKAIMNNTWGLNVVLNPDQHSVVLLLAQSLDPRKPQTMCEALKLLASFCIVYERNGYEKVL 259
            ..|....|......:..:.|.|:..:|          |||   ||           :.|....:.
Yeast   894 KDRLEPPIHIKKPKVKKMKNKDRKPLV----------KPQ---EA-----------DVNKLNDLR 934

  Fly   260 RAITTIAATS-----FKASERFRPIVDALFASDQQDPKRDLACHSLIFINTL------------- 306
            ||:..|...|     |...||    |:.||     :.|:.||...|..:.|.
Yeast   935 RALAEIQMESNDISKFNVEER----VNELF-----NEKKSLALKRLKELETKYKGFGIDFNVDEI 990

  Fly   307 ----------TNTPTDLNFRLHLRCEIMRMGLYDRLDEFTKIVEA-------------------- 341
                      ..|..|.|:     ..:.......:|||..:|.:.
Yeast   991 MDSPKKNTGDVETEEDANY-----ASLDPKTYQKKLDEINRITDQLLDIQTQTEHEIQVEEDGES 1050

  Fly   342 --------SNNENLQQHFKIFNEIREDDFE--------EFV----QRF---DNVT----FNMDDA 379
                    ..:|.:.|......|:|.:..|        .|:    |::   .|||    |..::.
Yeast  1051 DLSSSSSDDESEEIYQDASPTQELRSEHSELSSGSGPGSFLDALSQKYGTGQNVTASAAFGENNN 1115

  Fly   380 TDCFDVLKNLVTDT----------TSEPYFLSILQHLLYIRDDFYFRPAYYQLIEECISQIVFHK 434
            ......|.:.|..|          :|.||                        :||...::
Yeast  1116 GSGIGPLHSKVEKTFMNRLRKSTVSSAPY------------------------LEELTQKV---- 1152

  Fly   435 GYCDPNFENRNFNIDTSLLLDDIVEKAKAKESKRSEEYEKKIEQ-LESAKQ-----EAEAKAAHL 493
            ...:|..:|.:..:|..    .:.|.:.|..:...::.||.:.| :|:.||     ..|.|.|..
Yeast  1153 NKVEPYEQNEDEGLDKK----SLPENSTASAASAFDKAEKDMRQHVENGKQGRVVNHEEDKTADF 1213

  Fly   494 EEKVKLMEANGVAAPSPNKLPKVNIPMPPPPPGGGGAPPPPPPPMPGR----------------- 541
            ....||...:|....|...    ::....|||     |||||||:|.:
Yeast  1214 SAVSKLNNTDGAEDLSTQS----SVLSSQPPP-----PPPPPPPVPAKLFGESLEKEKKSEDDTV 1269

  Fly   542 ----AGGGPPPPPPPPMPGRAGGPPPPPPPPGMGG------PPPPPMPGMM---RPGGGPPPPPM 593
                .|..|.|||||        |||||||..:.|      |||||:|.::   ..|..||.|||
Yeast  1270 KQETTGDSPAPPPPP--------PPPPPPPMALFGKPKGETPPPPPLPSVLSSSTDGVIPPAPPM 1326

  Fly   594 MMGPMV------PVLPHG-------LKPKKKWDVKNPMKRANWKAIVPAKMSDKAFWVKCQEDKL 645
            |....:      |:||..       .:|.||      :|:.:|:.:   ..:|.:.|...:.:|.
Yeast  1327 MPASQIKSAVTSPLLPQSPSLFEKYPRPHKK------LKQLHWEKL---DCTDNSIWGTGKAEKF 1382

  Fly   646 AQDDF----LAELAVKFSSKPVK---KEQKDAVDKPTTLTKKNVDLRVLDSKTAQNLAIMLGGSL 703
            |.|.:    ||:|...|:::.:|   .::|:.:.|.|.|::   |:       :|...|.|
Yeast  1383 ADDLYEKGVLADLEKAFAAREIKSLASKRKEDLQKITFLSR---DI-------SQQFGINL---- 1433

  Fly   704 KHLSYEQIKIC-----LLRCDTDIL-----------------SSNILQQLIQYLPPPEHLKRLQE 746
             |: |..:.:.     :|.||.|.|                 |.|:.:....|....|.::.|::
Yeast  1434 -HM-YSSLSVADLVKKILNCDRDFLQTPSVVEFLSKSEIIEVSVNLARNYAPYSTDWEGVRNLED 1496

  Fly   747 IKAKGEPLPPIEQFAATIGEIKRL---------------SPRLHNLNFKLTYADMVQDIKPDIVA 796
            .|      ||.:.    ..:::|.               ..|:..|....:|.....::...:..
Yeast  1497 AK------PPEKD----PNDLQRADQIYLQLMVNLESYWGSRMRALTVVTSYEREYNELLAKLRK 1551

  Fly   797 GTAACEEIRNSKKFSKILELILLLGNYMNSGSKNEAAFGFEISYLTKLSNTKDADNKQTLLHYLA 861
            ...|...::.|.....:..:||.:||:||..||.  |.||::|.|.:|:..||..|..|.|:|:.
Yeast  1552 VDKAVSALQESDNLRNVFNVILAVGNFMNDTSKQ--AQGFKLSTLQRLTFIKDTTNSMTFLNYVE 1614

  Fly   862 DLVEKKFPDALNFYDDLSHVNKASRVNMDAIQKAMRQMNSAVKNLETDLQNNKVPQCDDDKF--- 923
            .:|...:|...:|..:|..|....:|:::.:....:..:.::.|:|..::...:  .|..||
Yeast  1615 KIVRLNYPSFNDFLSELEPVLDVVKVSIEQLVNDCKDFSQSIVNVERSVEIGNL--SDSSKFHPL 1677

  Fly   924 SEVMGK---FAEECRQQVDVL-GKMQLQMEKLYKDLSEYYAFDP-SKYTMEEFFADIKTFKDAFQ 983
            .:|:.|   ...|.|::.|:| .:::|.:.: ::.|...|..|. .|:....||.....|.:.::
Yeast  1678 DKVLIKTLPVLPEARKKGDLLEDEVKLTIME-FESLMHTYGEDSGDKFAKISFFKKFADFINEYK 1741

  Fly   984 AAHNDNVRVREELEKKRRLQEAREQSAREQQERQQRKKAVVDMDAPQTQEG-----------VMD 1037
            .|...|:...||    .||....::...|||:|.|.|:...:.....:.||           |||
Yeast  1742 KAQAQNLAAEEE----ERLYIKHKKIVEEQQKRAQEKEKQKENSNSPSSEGNEEDEAEDRRAVMD 1802

  Fly  1038 SLLEALQTGSAFGQRNRQARRQRPAGAERRAQLSRSRSRTRVTNGQLMTREMILNE 1093
            .|||.|        :|....:..|:.|.:|| |.|.:..:...|...:..::...|
Yeast  1803 KLLEQL--------KNAGPAKSDPSSARKRA-LVRKKYLSEKDNAPQLLNDLDTEE 1849

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
dia	NP_001246113.1	Drf_GBD	66..248	CDD:461886	44/201 (22%)
		Drf_FH3	253..453	CDD:461885	45/284 (16%)
		FH2	608..983	CDD:396655	89/426 (21%)
BNI1	NP_014128.2	Drf_GBD	178..458	CDD:461886
		Drf_FH3	511..707	CDD:461885
		PTZ00491	<690..801	CDD:240439	23/86 (27%)
		FH2	1348..1741	CDD:396655	89/432 (21%)
		PTZ00121	<1739..1841	CDD:173412	29/114 (25%)