DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dia and FHDC1

DIOPT Version :9

Sequence 1:	NP_001246113.1	Gene:	dia / 35340	FlyBaseID:	FBgn0011202	Length:	1098	Species:	Drosophila melanogaster
Sequence 2:	NP_001358045.1	Gene:	FHDC1 / 85462	HGNCID:	29363	Length:	1143	Species:	Homo sapiens

Alignment Length:	654	Identity:	159/654 - (24%)
Similarity:	259/654 - (39%)	Gaps:	142/654 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   492 HLEEKVKLM--EANGVAAPSPNKLPKVNIPMPPPPPGGGGAPPPPPPPMP------GRAGGGPPP 548
            |:...|.|:  :.||..|.:|..:.. ..|.|.|||     |||||||.|      ......|||
Human     2 HVMNCVSLVSDKENGNIATAPGFMIG-QTPPPAPPP-----PPPPPPPSPPCSCSREECPSSPPP 60

  Fly   549 PPPPPMPGRAGGPPPPPPPPGMGGPPPPPMPGMMRPGGGPPPPPMMMGPMVPVLPHGLKPKKKWD 613
            |||||:||.   ||.||||||:  ||...|.|....|                       |||
Human    61 PPPPPLPGE---PPIPPPPPGL--PPTTHMNGYSHLG-----------------------KKK-- 95

  Fly   614 VKNPMKRANWKAIVPAKMSDKA-FW-------------VKCQEDKLAQDDFLAELAVKFSSKPVK 664
               .|:...||.|...::..|. .|             .|..|:...|.:...:.::....:.:.
Human    96 ---RMRSFFWKTIPEEQVRGKTNIWTLAARQEHHYQIDTKTIEELFGQQEDTTKSSLPRRGRTLN 157

  Fly   665 KEQKDAVDKPTTLTKKNVDLRVLDSKTAQNLAIMLGGSLKHLSYEQIKICLLRCDTDILSSNILQ 729
            ...::|.:          ::.:||:|.:.|:.|.|....|  |...|...:.:..::...|..|:
Human   158 SSFREARE----------EITILDAKRSMNIGIFLKQFKK--SPRSIVEDIHQGKSEHYGSETLR 210

  Fly   730 QLIQYLPPPEHLKRLQEIKAKGEPLPPIEQFAATIGEIKRLSPRLHNLNFKLTYADMVQDIKPDI 794
            :.:::||..|.:|:|:........|...:.|...:.::...|.|:..:..|..:......:..||
Human   211 EFLKFLPESEEVKKLKAFSGDVSKLSLADSFLYGLIQVPNYSLRIEAMVLKKEFLPSCSSLYTDI 275

  Fly   795 VAGTAACEEIRNSKKFSKILELILLLGNYMNSGSKNEAAFGFEISYLTKLSNTKDADNKQTLLHY 859
            .....|.:|:.:.::...||.|:|..||.||:|.....|.||::|.|.||::||.......|||:
Human   276 TVLRTAIKELMSCEELHSILHLVLQAGNIMNAGGYAGNAVGFKLSSLLKLADTKANKPGMNLLHF 340

  Fly   860 LADLVEKKFPDALNFYDDLSHVNKASRVNMDAIQKAMRQMNSAVKNLETDLQNNKVPQCDDDKFS 924
            :|...:||....|||.:.|.||.|.:|::::..:..:..:....|:|:.::|.:
Human   341 VAQEAQKKDTILLNFSEKLHHVQKTARLSLENTEAELHLLFVRTKSLKENIQRD----------- 394

  Fly   925 EVMGKFAEECRQQVDVLGKMQLQMEKLYK-------------DLSEYYAFDPSKYTMEEFFADIK 976
                  .|.|:|..|.|   |..:|||.:             .|.:::..|.....::|.|...:
Human   395 ------GELCQQMEDFL---QFAIEKLRELECWKQELQDEAYTLIDFFCEDKKTMKLDECFQIFR 450

  Fly   977 TFKDAFQAAHNDNVRVREELEKKRRLQEAREQSAREQQERQQRKKAVVDMDA-----------PQ 1030
            .|...|..|..||        ..|..||.|:....::||::||..|..::.|           ..
Human   451 DFCTKFNKAVKDN--------HDREAQELRQLQRLKEQEQKQRSWATGELGAFGRSSSENDVELL 507

  Fly  1031 TQEGVMDSLLEALQTGSAFGQRNRQARRQRPAGAERRAQLSRSRSRTRVTNGQLMTREMI--LNE 1093
            |::|. :.||..|              ..||......:....:..|:|::.|....||::  |..
Human   508 TKKGA-EGLLPFL--------------HPRPISPSSPSYRPPNTRRSRLSLGPSADRELLTFLES 557

  Fly  1094 VLGS 1097
            ..||
Human   558 STGS 561

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dia	NP_001246113.1	Drf_GBD	66..248	CDD:283920
		Drf_FH3	253..453	CDD:283917
		FH2	608..983	CDD:280362	87/401 (22%)
FHDC1	NP_001358045.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	16..89		38/83 (46%)
		FH2	93..457	CDD:366959	87/400 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	517..638		11/59 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	706..1143
		PHA03307	730..>1136	CDD:223039
		MTBD, microtubule-binding domain. /evidence=ECO:0000269\|PubMed:18815276	960..1086
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1204639at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920