DRSC/TRiP Functional Genomics Resources

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Protein Alignment dia and FHDC1

DIOPT Version :10

Sequence 1:NP_001246113.1 Gene:dia / 35340 FlyBaseID:FBgn0011202 Length:1098 Species:Drosophila melanogaster
Sequence 2:NP_203751.2 Gene:FHDC1 / 85462 HGNCID:29363 Length:1143 Species:Homo sapiens


Alignment Length:654 Identity:159/654 - (24%)
Similarity:259/654 - (39%) Gaps:142/654 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly   492 HLEEKVKLM--EANGVAAPSPNKLPKVNIPMPPPPPGGGGAPPPPPPPMP------GRAGGGPPP 548
            |:...|.|:  :.||..|.:|..:.. ..|.|.|||     |||||||.|      ......|||
Human     2 HVMNCVSLVSDKENGNIATAPGFMIG-QTPPPAPPP-----PPPPPPPSPPCSCSREECPSSPPP 60

  Fly   549 PPPPPMPGRAGGPPPPPPPPGMGGPPPPPMPGMMRPGGGPPPPPMMMGPMVPVLPHGLKPKKKWD 613
            |||||:||.   ||.||||||:  ||...|.|....|                       |||  
Human    61 PPPPPLPGE---PPIPPPPPGL--PPTTHMNGYSHLG-----------------------KKK-- 95

  Fly   614 VKNPMKRANWKAIVPAKMSDKA-FW-------------VKCQEDKLAQDDFLAELAVKFSSKPVK 664
               .|:...||.|...::..|. .|             .|..|:...|.:...:.::....:.:.
Human    96 ---RMRSFFWKTIPEEQVRGKTNIWTLAARQEHHYQIDTKTIEELFGQQEDTTKSSLPRRGRTLN 157

  Fly   665 KEQKDAVDKPTTLTKKNVDLRVLDSKTAQNLAIMLGGSLKHLSYEQIKICLLRCDTDILSSNILQ 729
            ...::|.:          ::.:||:|.:.|:.|.|....|  |...|...:.:..::...|..|:
Human   158 SSFREARE----------EITILDAKRSMNIGIFLKQFKK--SPRSIVEDIHQGKSEHYGSETLR 210

  Fly   730 QLIQYLPPPEHLKRLQEIKAKGEPLPPIEQFAATIGEIKRLSPRLHNLNFKLTYADMVQDIKPDI 794
            :.:::||..|.:|:|:........|...:.|...:.::...|.|:..:..|..:......:..||
Human   211 EFLKFLPESEEVKKLKAFSGDVSKLSLADSFLYGLIQVPNYSLRIEAMVLKKEFLPSCSSLYTDI 275

  Fly   795 VAGTAACEEIRNSKKFSKILELILLLGNYMNSGSKNEAAFGFEISYLTKLSNTKDADNKQTLLHY 859
            .....|.:|:.:.::...||.|:|..||.||:|.....|.||::|.|.||::||.......|||:
Human   276 TVLRTAIKELMSCEELHSILHLVLQAGNIMNAGGYAGNAVGFKLSSLLKLADTKANKPGMNLLHF 340

  Fly   860 LADLVEKKFPDALNFYDDLSHVNKASRVNMDAIQKAMRQMNSAVKNLETDLQNNKVPQCDDDKFS 924
            :|...:||....|||.:.|.||.|.:|::::..:..:..:....|:|:.::|.:           
Human   341 VAQEAQKKDTILLNFSEKLHHVQKTARLSLENTEAELHLLFVRTKSLKENIQRD----------- 394

  Fly   925 EVMGKFAEECRQQVDVLGKMQLQMEKLYK-------------DLSEYYAFDPSKYTMEEFFADIK 976
                  .|.|:|..|.|   |..:|||.:             .|.:::..|.....::|.|...:
Human   395 ------GELCQQMEDFL---QFAIEKLRELECWKQELQDEAYTLIDFFCEDKKTMKLDECFQIFR 450

  Fly   977 TFKDAFQAAHNDNVRVREELEKKRRLQEAREQSAREQQERQQRKKAVVDMDA-----------PQ 1030
            .|...|..|..||        ..|..||.|:....::||::||..|..::.|           ..
Human   451 DFCTKFNKAVKDN--------HDREAQELRQLQRLKEQEQKQRSWATGELGAFGRSSSENDVELL 507

  Fly  1031 TQEGVMDSLLEALQTGSAFGQRNRQARRQRPAGAERRAQLSRSRSRTRVTNGQLMTREMI--LNE 1093
            |::|. :.||..|              ..||......:....:..|:|::.|....||::  |..
Human   508 TKKGA-EGLLPFL--------------HPRPISPSSPSYRPPNTRRSRLSLGPSADRELLTFLES 557

  Fly  1094 VLGS 1097
            ..||
Human   558 STGS 561

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
diaNP_001246113.1 Drf_GBD 66..248 CDD:461886
Drf_FH3 253..453 CDD:461885
FH2 608..983 CDD:396655 87/401 (22%)
FHDC1NP_203751.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 16..89 38/83 (46%)
FH2 93..457 CDD:396655 87/400 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 517..638 11/59 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 706..1143
PHA03307 730..>1136 CDD:223039
MTBD, microtubule-binding domain. /evidence=ECO:0000269|PubMed:18815276 960..1086
Blue background indicates that the domain is not in the aligned region.

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