DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dia and AT1G59910

DIOPT Version :9

Sequence 1:	NP_001246113.1	Gene:	dia / 35340	FlyBaseID:	FBgn0011202	Length:	1098	Species:	Drosophila melanogaster
Sequence 2:	NP_176199.1	Gene:	AT1G59910 / 842285	AraportID:	AT1G59910	Length:	929	Species:	Arabidopsis thaliana

Alignment Length:	615	Identity:	162/615 - (26%)
Similarity:	242/615 - (39%)	Gaps:	123/615 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   500 MEANGVAAPS----PNKLPKVNIPMPPPPPGGGGAPPPPPPPMPGRAGGGPPPPPPPPMPGRAGG 560
            |..|...:.|    |.:....|.|..||.|....:|||||||     ....|||||||..|.|.
plant   349 MPGNAALSASTPLTPGQFTTANAPPAPPGPANQTSPPPPPPP-----SAAAPPPPPPPKKGPAA- 407

  Fly   561 PPPPPPPPGMGGPPPPPMPGMMRPGGGPPPPP-MMMGPMV-------------PVLPHGLKPKKK 611
             ||||||||..|..|||.|.|.:.  |||.|| ...||..             |..|. ||| ..
plant   408 -PPPPPPPGKKGAGPPPPPPMSKK--GPPKPPGNPKGPTKSGETSLAVGKTEDPTQPK-LKP-LH 467

  Fly   612 WDVKNPMKRANWKAIVPAKMSDKAFWVKCQEDKLAQDDFLAELAVKFSSKPVKKEQKDAVDKPTT 676
            ||..||            ..|....|.|........|..|.|....:.::  |..:.::|.:..|
plant   468 WDKMNP------------DASRSMVWHKIDGGSFNFDGDLMEALFGYVAR--KPSESNSVPQNQT 518

  Fly   677 LTKK--NVDLRVLDSKTAQNLAIMLGGSLKHLSYEQIKICLLRCDTDILSSNILQQLIQYLPPPE 739
            ::..  :....:||.:.:||.||:    ||.|...:.:|..|..:.....|:.|::|....|.||
plant   519 VSNSVPHNQTYILDPRKSQNKAIV----LKSLGMTKEEIIDLLTEGHDAESDTLEKLAGIAPTPE 579

  Fly   740 HLKRLQEIKAKGEPLPPIEQFAATIGEIKRLSPRLHNLN---FKLTYADMVQDIKPDIVAGTAAC 801
              ::.:.|...|||:......:.....:|.:....:..|   ||:.|...|...|..::...:||
plant   580 --EQTEIIDFDGEPMTLAYADSLLFHILKAVPSAFNRFNVMLFKINYGSEVAQQKGSLLTLESAC 642

  Fly   802 EEIRNSKKFSKILELILLLGNYMNSGSKNEAAFGFEISYLTKLSNTKDADNKQTLLHYL------ 860
            .|:|....|.|:||.||..||.||:|:....|..|.::.|.|||:.|..|.|.||||::
plant   643 NELRARGLFMKLLEAILKAGNRMNAGTARGNAQAFNLTALRKLSDVKSVDAKTTLLHFVVEEVVR 707

  Fly   861 ----------------------ADL---------VEKKFPDALNFYDDLSHVNKASRVNMDAIQK 894
                                  ||:         ::...|.......:.::|.||:.::.|:...
plant   708 SEGKRAAMNKNMMSSDNGSGENADMSREEQEIEFIKMGLPIIGGLSSEFTNVKKAAGIDYDSFVA 772

  Fly   895 AMRQMNSAVKNLETDLQNNKVPQCDDDKFSEVMGKFAEECRQQVDVLGKMQLQMEKLYKDLSEYY 959
            ....:.:.||..:..|..:|   ..:|.....:..|.|...:::.|:.:.||::.:|.|..:.||
plant   773 TTLALGTRVKETKRLLDQSK---GKEDGCLTKLRSFFESAEEELKVITEEQLRIMELVKKTTNYY 834

  Fly   960 AFDPSK-YTMEEFFADIKTFKDAFQAAHNDNVRVREELEKKRRLQEAREQSAREQQERQQRKKAV 1023
            .....| ..:.:.|..|:.|....     ||               |..:.||.|:::||::.|.
plant   835 QAGALKERNLFQLFVIIRDFLGMV-----DN---------------ACSEIARNQRKQQQQRPAT 879

  Fly  1024 VDMDAPQTQEGVMDSLLEALQTGSAFGQRN 1053
                   |..|...|..|.....:| .|||
plant   880 -------TVAGASSSPAETPSVAAA-PQRN 901

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dia	NP_001246113.1	Drf_GBD	66..248	CDD:283920
		Drf_FH3	253..453	CDD:283917
		FH2	608..983	CDD:280362	95/417 (23%)
AT1G59910	NP_176199.1	PHA03247	<242..363	CDD:223021	3/13 (23%)
AT1G59910	NP_176199.1	FH2	453..859	CDD:366959	99/435 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	116	1.000	Inparanoid score	I2015
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1204639at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X420
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.970