Protein Alignment dia and AFH14

DIOPT Version :10

• Sequence 1: NP_001246113.1
• Gene: dia / 35340
• FlyBaseID: FBgn0011202
• Length: 1098
• Species: Drosophila melanogaster
• Sequence 2: NP_174461.3
• Gene: AFH14 / 840068
• AraportID: AT1G31810
• Length: 1230
• Species: Arabidopsis thaliana
• Alignment Length: 624
• Identity: 172/624 - (27%)
• Similarity: 278/624 - (44%)
• Gaps: 126/624 - (20%)

  Fly   508 PSPNKLPKVNIPMPPPPP----GGGG------APPPPPPPMPGR---AGGGPPPPPPPPMP---- 555
            ||...:|..:.|.|||||    |..|      .|||||||.|.|   |...||||||||..
plant   629 PSSRSIPSPSAPPPPPPPPPSFGSTGNKRQAQPPPPPPPPPPTRIPAAKCAPPPPPPPPTSHSGS 693

  Fly   556 ---GRAGGPPPPPPPP----------------------GMGGPPPPPMPGMMRPGGGPPPPPMMM 595
               |....||||||||                      .:|.|||||.|.:.:. ..|||||:..
plant   694 IRVGPPSTPPPPPPPPPKANISNAPKPPAPPPLPPSSTRLGAPPPPPPPPLSKT-PAPPPPPLSK 757

  Fly   596 GPMVPVLPHGL---------------------------------------------KPKKKWDVK 615
            .| ||..|.||                                             .||     |
plant   758 TP-VPPPPPGLGRGTSSGPPPLGAKGSNAPPPPPPAGRGRASLGLGRGRGVSVPTAAPK-----K 816

  Fly   616 NPMKRANWKAIVPAKMSDKAFWVKCQEDK---LAQDDFLAELAVKFSSKPVKKEQKDAVDKPTTL 677
            ..:|..:|..:..|  :..:.|...|:.:   .|.:..::||...||:......:|....:.:::
plant   817 TALKPLHWSKVTRA--AKGSLWADTQKQENQPRAPEIDISELESLFSAVSDTTAKKSTGRRGSSI 879

  Fly   678 TKKNVDLRVLDSKTAQNLAIMLGGSLKHLSYEQIKI-------CLLRCDTDILSSNILQQLIQYL 735
            :|.. .::::|.:.|.|..|||         .:|||       .:|..|:..|..:.::.||::.
plant   880 SKPE-KVQLVDLRRANNCEIML---------TKIKIPLPDMLSAVLALDSLALDIDQVENLIKFC 934

  Fly   736 PPPEHLKRLQEIKAKGEPLPPIEQFAATIGEIKRLSPRLHNLNFKLTYADMVQDIKPDIVAGTAA 800
            |..|.::.|:......|.|...|||...:.::.|:..:|....||:|:|..|:::|..:....||
plant   935 PTKEEMELLRNYTGDKEMLGKCEQFFMELMKVPRIEAKLRVFGFKITFASQVEELKSCLNTINAA 999

  Fly   801 CEEIRNSKKFSKILELILLLGNYMNSGSKNEAAFGFEISYLTKLSNTKDADNKQTLLHYLADLVE 865
            .:|::.|.|..:|::.||.|||.:|.|:...:|.||::..|.|||:|:..:||.||:|||..||.
plant  1000 TKEVKESAKLRQIMQTILTLGNALNQGTARGSAVGFKLDSLLKLSDTRARNNKMTLMHYLCKLVG 1064

  Fly   866 KKFPDALNFYDDLSHVNKASRVNMDAIQKAMRQMNSAVKNLETDLQNNKVPQCDDDKFSEVMGKF 930
            :|.|:.|:|.:||.|:..||::.:..:.:.|:.....::.:|.:|..::........|.:|:.:|
plant  1065 EKMPELLDFANDLVHLEAASKIELKTLAEEMQAATKGLEKVEQELMASENDGAISLGFRKVLKEF 1129

  Fly   931 AEECRQQVDVLGKMQLQMEKLYKDLSEYYAFDPSKYTMEEFFADIKTFKDAFQAAHNDNVRVREE 995
            .:...::|..|..:..::.:....||.|:..||::...|:....:..|...|..:..:|.: :.|
plant  1130 LDMADEEVKTLASLYSEVGRNADSLSHYFGEDPARCPFEQVTKILTLFMKTFIKSREENEK-QAE 1193

  Fly   996 LEKKRRLQEA-REQSAREQQERQQRKKAVVDMDAPQTQE 1033
            .|||:..:|| :|:||        .||..||.|....|:
plant  1194 AEKKKLEKEAIKEKSA--------TKKDGVDNDNDLIQQ 1224

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
dia	NP_001246113.1	Drf_GBD	66..248	CDD:461886
		Drf_FH3	253..453	CDD:461885
		FH2	608..983	CDD:396655	99/384 (26%)
AFH14	NP_174461.3	PTP_DSP_cys	21..190	CDD:475123
		PTEN_C2	198..338	CDD:463081
		FH2	814..1181	CDD:396655	99/383 (26%)