DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dia and FH6

DIOPT Version :9

Sequence 1:	NP_001246113.1	Gene:	dia / 35340	FlyBaseID:	FBgn0011202	Length:	1098	Species:	Drosophila melanogaster
Sequence 2:	NP_201548.1	Gene:	FH6 / 836883	AraportID:	AT5G67470	Length:	899	Species:	Arabidopsis thaliana

Alignment Length:	723	Identity:	164/723 - (22%)
Similarity:	262/723 - (36%)	Gaps:	232/723 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   466 SKRSEEYEKKIEQLESAKQEAEAKAAHLEEKVKLMEANGVAAPSPNKLPKVNIPMPPPPPGGGGA 530
            |||:....|    ..||...|.:::..::..:               :|.:...:|||      .
plant   281 SKRTSPRSK----FGSAPTTAASRSPEMKHVI---------------IPSIKQKLPPP------V 320

  Fly   531 PPPP----------------------PPPMPGRAG-------GGPPPPP---PPPMPGRAGGPPP 563
            .|||                      |||.|.||.       ..|.|||   |||:.    .|||
plant   321 QPPPLRGLESDEQELPYSQNKPKFSQPPPPPNRAAFQAITQEKSPVPPPRRSPPPLQ----TPPP 381

  Fly   564 PPPPPGMGGPPPP----------------------------------PMP--------------G 580
            |||||.:..||||                                  |.|              .
plant   382 PPPPPPLAPPPPPQKRPRDFQMLRKVTNSEATTNSTTSPSRKQAFKTPSPKTKAVEEVNSVSAGS 446

  Fly   581 MMRPGGGPPPPPMMMGPMVPVLPHGLKPKKK---WDVKNPMKRANWKAIVPAKMSDKAFWVKCQE 642
            :.:.|.|...|.              |||.|   ||   .::.::.:|.|..::...:|  :..|
plant   447 LEKSGDGDTDPS--------------KPKLKPLHWD---KVRASSDRATVWDQLKSSSF--QLNE 492

  Fly   643 DKLAQDDFLAELAVKFSSKPVKKEQKDAVDKPTTLTKKNVDLRVLDSKTAQNLAIMLGGSLKHLS 707
            |::..         .|.........|:.|.:......:| :.||||.|.:||:||:|  ...:::
plant   493 DRMEH---------LFGCNSGSSAPKEPVRRSVIPLAEN-ENRVLDPKKSQNIAILL--RALNVT 545

  Fly   708 YEQIKICLLRCDTDILSSNILQQLIQYLPPPEHLKRLQEIKAKGEPLPPIEQFAATIGEI----K 768
            .|::...|...:.:.|.:.:|:.|::..|..|...:|:|.......|...|:|..||.:|    |
plant   546 REEVSEALTDGNPESLGAELLETLVKMAPTKEEEIKLREYSGDVSKLGTAERFLKTILDIPFAFK 610

  Fly   769 RLSPRLHNLNFKLTYADMVQDIKPDIVAGTAACEEIRNSKKFSKILELILLLGNYMNSGSKNEAA 833
            |:...|:..||...    |:.::........|..|::.|:.|.|:||.:|:.||.||.|:....|
plant   611 RVEAMLYRANFDAE----VKYLRNSFQTLEEASLELKASRLFLKLLEAVLMTGNRMNVGTNRGDA 671

  Fly   834 FGFEISYLTKLSNTKDADNKQTLLHYLADLVEKKFPDALNFYDDLSHVNKASRVNMDAIQKAMRQ 898
            ..|::..|.||.:.|..|.|.||||::...:.:.........:.:.|.|.      |..:|...|
plant   672 IAFKLDTLLKLVDIKGVDGKTTLLHFVVQEITRSEGTTTTKDETILHGNN------DGFRKQGLQ 730

  Fly   899 MNSAVKNLETDLQNNKVPQCDDDKFSEVMGKFAEECRQQVDVLG----KMQLQMEKLYKDLSEYY 959
            :   |..|..||.|.|                 :......|||.    |:::.::||       .
plant   731 V---VAGLSRDLVNVK-----------------KSAGMDFDVLSSYVTKLEMGLDKL-------R 768

  Fly   960 AFDPSKYTMEEFFADIKTF-KDAFQAAHNDNVRVREELEK-----KRRLQEARE-------QSAR 1011
            :|..::.|...||..:||| |:|           .||:.|     ::.|...:|       .:||
plant   769 SFLKTETTQGRFFDSMKTFLKEA-----------EEEIRKIKGGERKALSMVKEVTEYFHGNAAR 822

  Fly  1012 EQQERQQRKKAVVDMDAPQTQEGVMDSLLEALQT--------GSAFGQRNRQARRQRPAGAERRA 1068
            |:....:....|.|.      .||:|::.:.::|        |||      .||..|.:......
plant   823 EEAHPLRIFMVVRDF------LGVLDNVCKEVKTMQEMSTSMGSA------SARSFRISATASLP 875

  Fly  1069 QLSRSRSR 1076
            .|.|.::|
plant   876 VLHRYKAR 883

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dia	NP_001246113.1	Drf_GBD	66..248	CDD:283920
		Drf_FH3	253..453	CDD:283917
		FH2	608..983	CDD:280362	96/386 (25%)
FH6	NP_201548.1	FH2	452..842	CDD:280362	111/474 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	116	1.000	Inparanoid score	I2015
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1204639at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X420
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.970