DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dia and AT5G58160

DIOPT Version :9

Sequence 1:	NP_001246113.1	Gene:	dia / 35340	FlyBaseID:	FBgn0011202	Length:	1098	Species:	Drosophila melanogaster
Sequence 2:	NP_001318825.1	Gene:	AT5G58160 / 835928	AraportID:	AT5G58160	Length:	1266	Species:	Arabidopsis thaliana

Alignment Length:	645	Identity:	168/645 - (26%)
Similarity:	286/645 - (44%)	Gaps:	101/645 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   488 AKAAHLEEKVKLMEANGVAAPSP------NKLPKVNIPMPPPPPGGGGAP---------PPPPPP 537
            |.:.||.....:....|..|.||      :|.|.:..|.|||||    .|         ||||||
plant   652 ATSPHLGASDNVASNLGQPARSPPPISNSDKKPALPRPPPPPPP----PPMQHSTVTKVPPPPPP 712

  Fly   538 MPG-------RAGGGPPPPPPPPMPG----RAGG-------PPPPPPPPGM----------GGPP 574
            .|.       .....||||||||.|.    ::.|       ||.||.||.:          ..||
plant   713 APPAPPTPIVHTSSPPPPPPPPPPPAPPTPQSNGISAMKSSPPAPPAPPRLPTHSASPPPPTAPP 777

  Fly   575 PPPMPGMMRPGGGPPPPPMMMG----------PMVPVLPHGLKPKKKWDVKNPMKRANWKAIVPA 629
            |||: |..|....|||||..:|          |..|.||.|  |....  |..|.|.|.|. .||
plant   778 PPPL-GQTRAPSAPPPPPPKLGTKLSPSGPNVPPTPALPTG--PLSSG--KGRMLRVNLKN-SPA 836

  Fly   630 KMSDKAFWVK---------------CQEDKLAQDDFLAELAVKFSSKPVKKEQKDAVDKPTTLTK 679
            |......|:|               ..|...|.|..:.||...||:...::..|..:|  ::...
plant   837 KKLKPYHWLKLTRAVNGSLWAETQMSSEASKAPDIDMTELESLFSASAPEQAGKSRLD--SSRGP 899

  Fly   680 KNVDLRVLDSKTAQNLAIMLGGSLKHLSYEQIKICLLRCDTDILSSNILQQLIQYLPPPEHLKRL 744
            |...:::::.:.|.|..|||  |...:..:.:...:|..:...|.::.::.||::.|..|.::.|
plant   900 KPEKVQLIEHRRAYNCEIML--SKVKVPLQDLTNSVLNLEESALDADQVENLIKFCPTREEMELL 962

  Fly   745 QEIKAKGEPLPPIEQFAATIGEIKRLSPRLHNLNFKLTYADMVQDIKPDIVAGTAACEEIRNSKK 809
            :......:.|...|.|...:.::.|:..:|...:||:.:...:.:::..:....:|.|:::||:|
plant   963 KGYTGDKDKLGKCELFFLEMMKVPRVETKLRVFSFKMQFTSQISELRNSLGVVNSAAEQVKNSEK 1027

  Fly   810 FSKILELILLLGNYMNSGSKNEAAFGFEISYLTKLSNTKDADNKQTLLHYLADLVEKKFPDALNF 874
            |.:|::.||.|||.:|.|:...||.||::..|.|||.|:..:|:.||:|||..::.:|.|:.|:|
plant  1028 FKRIMQTILSLGNALNQGTARGAAVGFKLDSLPKLSETRARNNRMTLMHYLCKILAEKIPEVLDF 1092

  Fly   875 YDDLSHVNKASRVNMDAIQKAMRQMNSAVKNL--ETDLQNNKVPQCDDDKFSEVMGKFAEECRQQ 937
            ..:||.:..|:::.:..:.:.|:.:|..::.:  |..|..|..|  ....|::::.:|......:
plant  1093 TKELSSLEPATKIQLKFLAEEMQAINKGLEKVVQELSLSENDGP--ISHNFNKILKEFLHYAEAE 1155

  Fly   938 VDVLGKMQLQMEKLYKDLSEYYAFDPSKYTMEEFFADIKTFKDAFQAAHNDNVRVREELEKKRRL 1002
            |..|..:...:.:....|..|:..||:|...|:..:.:..|...|..||.:|   .::||
plant  1156 VRSLASLYSGVGRNVDGLILYFGEDPAKCPFEQVVSTLLNFVRLFNRAHEEN---GKQLE----- 1212

  Fly  1003 QEAREQSAREQQERQQRKKAVVDMDAPQTQEGVMDSLLEALQTGSAFGQRNRQARRQRPA 1062
            .||::.:|    |:::.|...:|   .:.::.:.:.:.|.....|..|:......::|.|
plant  1213 AEAKKNAA----EKEKPKTGGLD---TEIKKPLNEEVKEEKTKTSGLGKEMSDRLKERTA 1265

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dia	NP_001246113.1	Drf_GBD	66..248	CDD:283920
		Drf_FH3	253..453	CDD:283917
		FH2	608..983	CDD:280362	94/391 (24%)
AT5G58160	NP_001318825.1	PTP_PTEN-like	16..189	CDD:350347
		PTEN_C2	197..336	CDD:402161
		FH2	835..1201	CDD:396655	88/371 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1204639at2759
OrthoFinder	1	1.000	-	-		FOG0000085
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.920