DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dia and DIAPH3

DIOPT Version :9

Sequence 1:	NP_001246113.1	Gene:	dia / 35340	FlyBaseID:	FBgn0011202	Length:	1098	Species:	Drosophila melanogaster
Sequence 2:	NP_001035982.1	Gene:	DIAPH3 / 81624	HGNCID:	15480	Length:	1193	Species:	Homo sapiens

Alignment Length:	1044	Identity:	404/1044 - (38%)
Similarity:	626/1044 - (59%)	Gaps:	61/1044 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    50 SADNYVVPGVEDFEQYIQQLSVAELDAKFLEIIEDMNIPKDKREPLLAKSKEERQKMIMWHLKGK 114
            |:|....| :|..|.:.:.||..||...|.:::||||:.:||:.||..|....:::|:|.::...
Human    99 SSDCSAAP-LEMMENFPKPLSENELLELFEKMMEDMNLNEDKKAPLREKDFSIKKEMVMQYINTA 162

  Fly   115 NSLERSANSRFEKPIDYVEYLQNGEHSTHKVYQCVESLRVALTSNPISWIKEFGVAGIG----TI 175
            :.......||...|.:::..|:.|. :..::..|:|||||:|||||:||::.||..|:|    .:
Human   163 SKTGSLKRSRQISPQEFIHELKMGS-ADERLVTCLESLRVSLTSNPVSWVESFGHEGLGLLLDIL 226

  Fly   176 EKLLARSKNNASYEKIEFEAIRCLKAIMNNTWGLNVVLNPDQHSVVLLLAQSLDPRKPQTMCEAL 240
            |||::........:|.:.:.|:||||:||..:||..:::.::.  :.|||:::|||.|..|.:.:
Human   227 EKLISGKIQEKVVKKNQHKVIQCLKALMNTQYGLERIMSEERS--LSLLAKAVDPRHPNMMTDVV 289

  Fly   241 KLLASFCIVYERNGYEKVLRAITTIAATSFKASERFRPIVDALFASDQQDPKRDLACHSLIFINT 305
            |||::.|||.|.:..|:||.|:|  :|...|..:||..||:.|..:..|   ..:||..|  ||.
Human   290 KLLSAVCIVGEESILEEVLEALT--SAGEEKKIDRFFCIVEGLRHNSVQ---LQVACMQL--INA 347

  Fly   306 LTNTPTDLNFRLHLRCEIMRMGLYDRLDEFTKIVEASNNENLQQHFKIFNEIREDDFEEFVQRFD 370
            |..:|.||:||||:|.|.||.||.:.|..    ::...|:.|....|:|:|.:|:|..|...|.:
Human   348 LVTSPDDLDFRLHIRNEFMRCGLKEILPN----LKCIKNDGLDIQLKVFDEHKEEDLFELSHRLE 408

  Fly   371 NVTFNMDDATDCFDVLKNLVTDTTSEPYFLSILQHLLYIRDDFYFRPAYYQLIEECISQIVFHKG 435
            ::...:|:|.|.::::.:.|.:|.:|.||:|||||||.||:|::.|..|::||:||:||||.|:.
Human   409 DIRAELDEAYDVYNMVWSTVKETRAEGYFISILQHLLLIRNDYFIRQQYFKLIDECVSQIVLHRD 473

  Fly   436 YCDPNFENR-NFNIDTSLLLDDIVEKAKAK--ESKRSEEYEKKIEQLESAKQEAEAKAAHLEEKV 497
            ..||:|..| ..::|.:..:|..:::||.:  |.|.||.| ||.|:..:..||.:|:....|.|:
Human   474 GMDPDFTYRKRLDLDLTQFVDICIDQAKLEEFEEKASELY-KKFEKEFTDHQETQAELQKKEAKI 537

  Fly   498 KLMEANGVAAPSP-NKLP-KVNIPMPPPPPGG-GGAPPPPPPPMPGRAGGGPPPPPPPPMPGRAG 559
            ..::|...|..|. ..|| ..|||:||...|| |.:..|||||:|  :|||.||||||
Human   538 NELQAELQAFKSQFGALPADCNIPLPPSKEGGTGHSALPPPPPLP--SGGGVPPPPPP------- 593

  Fly   560 GPPPPPPPPGMGGPPPPPMPGMMRPGGGPPPPPMMMG-------PMVPVLPHGLKPKKKWDVKNP 617
                         |||||:|||..|..||.|||..:|       |.:|:||.||||||::..:..
Human   594 -------------PPPPPLPGMRMPFSGPVPPPPPLGFLGGQNSPPLPILPFGLKPKKEFKPEIS 645

  Fly   618 MKRANWKAIVPAKMSDKAFWVKCQEDKLAQDDFLAELAVKFSSKPVKKEQKDAVDKPTTLTKKNV 682
            |:|.||..|.|.:|::..||:|..|:|....|.|.:|...|..:..::.:::.:::..::.||..
Human   646 MRRLNWLKIRPHEMTENCFWIKVNENKYENVDLLCKLENTFCCQQKERREEEDIEEKKSIKKKIK 710

  Fly   683 DLRVLDSKTAQNLAIMLGGSLKHLSYEQIKICLLRCDTDILSSNILQQLIQYLPPPEHLKRLQEI 747
            :|:.||||.||||:|.|  |...:.||:|::.:|..|...|:.:::|.||::||..|.|..|.:.
Human   711 ELKFLDSKIAQNLSIFL--SSFRVPYEEIRMMILEVDETRLAESMIQNLIKHLPDQEQLNSLSQF 773

  Fly   748 KAKGEPLPPIEQFAATIGEIKRLSPRLHNLNFKLTYADMVQDIKPDIVAGTAACEEIRNSKKFSK 812
            |::...|...|||...:..:|||.|||..:.|||.:.:.|.:|||||:|.:.|||||:.||.|||
Human   774 KSEYSNLCEPEQFVVVMSNVKRLRPRLSAILFKLQFEEQVNNIKPDIMAVSTACEEIKKSKSFSK 838

  Fly   813 ILELILLLGNYMNSGSKNEAAFGFEISYLTKLSNTKDADNKQTLLHYLADLVEKKFPDALNFYDD 877
            :|||:||:|||||:||:|...|||.:|.|.||.:||.||.|.||||:|.::.|:|:||.|||.||
Human   839 LLELVLLMGNYMNAGSRNAQTFGFNLSSLCKLKDTKSADQKTTLLHFLVEICEEKYPDILNFVDD 903

  Fly   878 LSHVNKASRVNMDAIQKAMRQMNSAVKNLETDLQNNKVPQCDDDKFSEVMGKFAEECRQQVDVLG 942
            |..::|||:|:::.::|.:|||...::.||.:|:....|:...|||...|.:|....::|.:.|.
Human   904 LEPLDKASKVSVETLEKNLRQMGRQLQQLEKELETFPPPEDLHDKFVTKMSRFVISAKEQYETLS 968

  Fly   943 KMQLQMEKLYKDLSEYYAFDPSKYTMEEFFADIKTFKDAFQAAHNDNVRVREELEKKRRLQEARE 1007
            |:...|||||:.:..|||.|..|.::|:|..|:..|:..|..|..:|::.||..||::|::.|:|
Human   969 KLHENMEKLYQSIIGYYAIDVKKVSVEDFLTDLNNFRTTFMQAIKENIKKREAEEKEKRVRIAKE 1033

  Fly  1008 QSAREQQERQQRKKAVVDMDAPQTQEGVMDSLLEALQTGSAFGQRNRQARRQRPAGAERRAQLSR 1072
            .:.||:.||||:||.:::|.....:.||||:||||||:|:||    |..|::.|...:.|..||.
Human  1034 LAERERLERQQKKKRLLEMKTEGDETGVMDNLLEALQSGAAF----RDRRKRTPMPKDVRQSLSP 1094

  Fly  1073 SRSR 1076
            ...|
Human  1095 MSQR 1098

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dia	NP_001246113.1	Drf_GBD	66..248	CDD:283920	62/185 (34%)
		Drf_FH3	253..453	CDD:283917	76/200 (38%)
		FH2	608..983	CDD:280362	152/374 (41%)
DIAPH3	NP_001035982.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..57
		Nuclear localization signal. /evidence=ECO:0000250\|UniProtKB:Q9Z207	36..60
		Drf_GBD	115..297	CDD:283920	62/184 (34%)
		Drf_FH3	305..488	CDD:283917	75/193 (39%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	558..622		38/85 (45%)
		FH2	636..1008	CDD:280362	152/373 (41%)
		Nuclear export signal. /evidence=ECO:0000250\|UniProtKB:Q9Z207	1184..1193
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	324	1.000	Domainoid score	I1200
eggNOG	1	0.900	-	-		E1_KOG1924
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	749	1.000	Inparanoid score	I582
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG52328
OrthoDB	1	1.010	-	-		D1204639at2759
OrthoFinder	1	1.000	-	-		FOG0000085
OrthoInspector	1	1.000	-	-		otm42200
orthoMCL	1	0.900	-	-		OOG6_101727
Panther	1	1.100	-	-	O	PTHR45691
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3069
SonicParanoid	1	1.000	-	-		X420
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	14	13.870