Protein Alignment dia and DIAPH3

DIOPT Version :10

• Sequence 1: NP_001246113.1
• Gene: dia / 35340
• FlyBaseID: FBgn0011202
• Length: 1098
• Species: Drosophila melanogaster
• Sequence 2: NP_001035982.1
• Gene: DIAPH3 / 81624
• HGNCID: 15480
• Length: 1193
• Species: Homo sapiens
• Alignment Length: 1044
• Identity: 404/1044 - (38%)
• Similarity: 626/1044 - (59%)
• Gaps: 61/1044 - (5%)

  Fly    50 SADNYVVPGVEDFEQYIQQLSVAELDAKFLEIIEDMNIPKDKREPLLAKSKEERQKMIMWHLKGK 114
            |:|....| :|..|.:.:.||..||...|.:::||||:.:||:.||..|....:::|:|.::...
Human    99 SSDCSAAP-LEMMENFPKPLSENELLELFEKMMEDMNLNEDKKAPLREKDFSIKKEMVMQYINTA 162

  Fly   115 NSLERSANSRFEKPIDYVEYLQNGEHSTHKVYQCVESLRVALTSNPISWIKEFGVAGIG----TI 175
            :.......||...|.:::..|:.|. :..::..|:|||||:|||||:||::.||..|:|    .:
Human   163 SKTGSLKRSRQISPQEFIHELKMGS-ADERLVTCLESLRVSLTSNPVSWVESFGHEGLGLLLDIL 226

  Fly   176 EKLLARSKNNASYEKIEFEAIRCLKAIMNNTWGLNVVLNPDQHSVVLLLAQSLDPRKPQTMCEAL 240
            |||::........:|.:.:.|:||||:||..:||..:::.::.  :.|||:::|||.|..|.:.:
Human   227 EKLISGKIQEKVVKKNQHKVIQCLKALMNTQYGLERIMSEERS--LSLLAKAVDPRHPNMMTDVV 289

  Fly   241 KLLASFCIVYERNGYEKVLRAITTIAATSFKASERFRPIVDALFASDQQDPKRDLACHSLIFINT 305
            |||::.|||.|.:..|:||.|:|  :|...|..:||..||:.|..:..|   ..:||..|  ||.
Human   290 KLLSAVCIVGEESILEEVLEALT--SAGEEKKIDRFFCIVEGLRHNSVQ---LQVACMQL--INA 347

  Fly   306 LTNTPTDLNFRLHLRCEIMRMGLYDRLDEFTKIVEASNNENLQQHFKIFNEIREDDFEEFVQRFD 370
            |..:|.||:||||:|.|.||.||.:.|..    ::...|:.|....|:|:|.:|:|..|...|.:
Human   348 LVTSPDDLDFRLHIRNEFMRCGLKEILPN----LKCIKNDGLDIQLKVFDEHKEEDLFELSHRLE 408

  Fly   371 NVTFNMDDATDCFDVLKNLVTDTTSEPYFLSILQHLLYIRDDFYFRPAYYQLIEECISQIVFHKG 435
            ::...:|:|.|.::::.:.|.:|.:|.||:|||||||.||:|::.|..|::||:||:||||.|:.
Human   409 DIRAELDEAYDVYNMVWSTVKETRAEGYFISILQHLLLIRNDYFIRQQYFKLIDECVSQIVLHRD 473

  Fly   436 YCDPNFENR-NFNIDTSLLLDDIVEKAKAK--ESKRSEEYEKKIEQLESAKQEAEAKAAHLEEKV 497
            ..||:|..| ..::|.:..:|..:::||.:  |.|.||.| ||.|:..:..||.:|:....|.|:
Human   474 GMDPDFTYRKRLDLDLTQFVDICIDQAKLEEFEEKASELY-KKFEKEFTDHQETQAELQKKEAKI 537

  Fly   498 KLMEANGVAAPSP-NKLP-KVNIPMPPPPPGG-GGAPPPPPPPMPGRAGGGPPPPPPPPMPGRAG 559
            ..::|...|..|. ..|| ..|||:||...|| |.:..|||||:|  :|||.||||||
Human   538 NELQAELQAFKSQFGALPADCNIPLPPSKEGGTGHSALPPPPPLP--SGGGVPPPPPP------- 593

  Fly   560 GPPPPPPPPGMGGPPPPPMPGMMRPGGGPPPPPMMMG-------PMVPVLPHGLKPKKKWDVKNP 617
                         |||||:|||..|..||.|||..:|       |.:|:||.||||||::..:..
Human   594 -------------PPPPPLPGMRMPFSGPVPPPPPLGFLGGQNSPPLPILPFGLKPKKEFKPEIS 645

  Fly   618 MKRANWKAIVPAKMSDKAFWVKCQEDKLAQDDFLAELAVKFSSKPVKKEQKDAVDKPTTLTKKNV 682
            |:|.||..|.|.:|::..||:|..|:|....|.|.:|...|..:..::.:::.:::..::.||..
Human   646 MRRLNWLKIRPHEMTENCFWIKVNENKYENVDLLCKLENTFCCQQKERREEEDIEEKKSIKKKIK 710

  Fly   683 DLRVLDSKTAQNLAIMLGGSLKHLSYEQIKICLLRCDTDILSSNILQQLIQYLPPPEHLKRLQEI 747
            :|:.||||.||||:|.|  |...:.||:|::.:|..|...|:.:::|.||::||..|.|..|.:.
Human   711 ELKFLDSKIAQNLSIFL--SSFRVPYEEIRMMILEVDETRLAESMIQNLIKHLPDQEQLNSLSQF 773

  Fly   748 KAKGEPLPPIEQFAATIGEIKRLSPRLHNLNFKLTYADMVQDIKPDIVAGTAACEEIRNSKKFSK 812
            |::...|...|||...:..:|||.|||..:.|||.:.:.|.:|||||:|.:.|||||:.||.|||
Human   774 KSEYSNLCEPEQFVVVMSNVKRLRPRLSAILFKLQFEEQVNNIKPDIMAVSTACEEIKKSKSFSK 838

  Fly   813 ILELILLLGNYMNSGSKNEAAFGFEISYLTKLSNTKDADNKQTLLHYLADLVEKKFPDALNFYDD 877
            :|||:||:|||||:||:|...|||.:|.|.||.:||.||.|.||||:|.::.|:|:||.|||.||
Human   839 LLELVLLMGNYMNAGSRNAQTFGFNLSSLCKLKDTKSADQKTTLLHFLVEICEEKYPDILNFVDD 903

  Fly   878 LSHVNKASRVNMDAIQKAMRQMNSAVKNLETDLQNNKVPQCDDDKFSEVMGKFAEECRQQVDVLG 942
            |..::|||:|:::.::|.:|||...::.||.:|:....|:...|||...|.:|....::|.:.|.
Human   904 LEPLDKASKVSVETLEKNLRQMGRQLQQLEKELETFPPPEDLHDKFVTKMSRFVISAKEQYETLS 968

  Fly   943 KMQLQMEKLYKDLSEYYAFDPSKYTMEEFFADIKTFKDAFQAAHNDNVRVREELEKKRRLQEARE 1007
            |:...|||||:.:..|||.|..|.::|:|..|:..|:..|..|..:|::.||..||::|::.|:|
Human   969 KLHENMEKLYQSIIGYYAIDVKKVSVEDFLTDLNNFRTTFMQAIKENIKKREAEEKEKRVRIAKE 1033

  Fly  1008 QSAREQQERQQRKKAVVDMDAPQTQEGVMDSLLEALQTGSAFGQRNRQARRQRPAGAERRAQLSR 1072
            .:.||:.||||:||.:::|.....:.||||:||||||:|:||    |..|::.|...:.|..||.
Human  1034 LAERERLERQQKKKRLLEMKTEGDETGVMDNLLEALQSGAAF----RDRRKRTPMPKDVRQSLSP 1094

  Fly  1073 SRSR 1076
            ...|
Human  1095 MSQR 1098

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
dia	NP_001246113.1	Drf_GBD	66..248	CDD:461886	62/185 (34%)
		Drf_FH3	253..453	CDD:461885	76/200 (38%)
		FH2	608..983	CDD:396655	152/374 (41%)
DIAPH3	NP_001035982.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..57
		Nuclear localization signal. /evidence=ECO:0000250|UniProtKB:Q9Z207	36..60
		Drf_GBD	114..297	CDD:461886	62/185 (34%)
		Drf_FH3	305..488	CDD:461885	75/193 (39%)
		CwlO1	499..>552	CDD:443091	18/53 (34%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	558..622		38/85 (45%)
		FH2	636..1008	CDD:396655	152/373 (41%)
		Nuclear export signal. /evidence=ECO:0000250|UniProtKB:Q9Z207	1184..1193