DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dia and FHOD3

DIOPT Version :9

Sequence 1:	NP_001246113.1	Gene:	dia / 35340	FlyBaseID:	FBgn0011202	Length:	1098	Species:	Drosophila melanogaster
Sequence 2:	XP_011524491.1	Gene:	FHOD3 / 80206	HGNCID:	26178	Length:	1642	Species:	Homo sapiens

Alignment Length:	800	Identity:	187/800 - (23%)
Similarity:	320/800 - (40%)	Gaps:	218/800 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   435 GYCDPNFENRNFNIDTSLLLDDIVEKAKAKESKRSEEYEKKIEQLESAKQEAEAKAAHLEEKVKL 499
            |.|.....|:.|.:|          ...|...|..::.||...:....:||||| .|.|..::..
Human   878 GQCGDILTNKRFMLD----------MLYAHNRKSPDDEEKGDGEAGRTQQEAEA-VASLATRIST 931

  Fly   500 MEAN----------------------------------GVAAPSPNKLPKVNIPMPPPPPGGGGA 530
            ::||                                  |..:.||:..|...:|..        |
Human   932 LQANSQTQDESVRRVDVGCLDNRGSVKAFAEKFNSGDLGRGSISPDAEPNDKVPET--------A 988

  Fly   531 PPPPPP-------------------------------------PMPGRAGGGPPPPPPPPMPGRA 558
            |..|..                                     .:..|...||||||||...|.
Human   989 PVQPKTESDYIWDQLMANPRELRIQDMDFTDLGEEDDIDVLDVDLGHREAPGPPPPPPPTFLGL- 1052

  Fly   559 GGPPPPPPPPGMGGPPPPPMPGMMRPGGGPPPPPMMMGPM---VPVLPHGLKP---KKKWDVK-- 615
               |||||||.:...||||:||.:.    .||||:...|.   ...:|.| :|   |||..::
Human  1053 ---PPPPPPPLLDSIPPPPVPGNLL----VPPPPVFNAPQGLGWSQVPRG-QPTFTKKKKTIRLF 1109

  Fly   616 -NPMKRANWKAIVPAKMSDKA---FWVKCQEDKLAQDDFLAELAVKFSSKPVKKEQKDAVDKPTT 676
             |.::..:|    |.|.:.:.   .|.|.:..|:.    .:.|...|.||  .||.  :|.|.|.
Human  1110 WNEVRPFDW----PCKNNRRCREFLWSKLEPIKVD----TSRLEHLFESK--SKEL--SVSKKTA 1162

  Fly   677 LTKKNVDLRVLDSKTAQNLAIMLGGSLKHLSY----EQIKICLLRCDTDILSSNILQQLIQYLPP 737
            ...|..::.|||||.:.  ||.:|     |:.    ..|||.:|..|...|:...:::::..:|.
Human  1163 ADGKRQEIIVLDSKRSN--AINIG-----LTVLPPPRTIKIAILNFDEYALNKEGIEKILTMIPT 1220

  Fly   738 PEHLKRLQEIK-AKGE-PLPPIEQFAATIGEIKRLSPRLHNLNFKLTYADMVQDIKPDIVAGTAA 800
            .|..:::||.: |..| ||...|||..|:..|..||.|||...||:.|....:::...::.....
Human  1221 DEEKQKIQEAQLANPEIPLGSAEQFLLTLSSISELSARLHLWAFKMDYETTEKEVAEPLLDLKEG 1285

  Fly   801 CEEIRNSKKFSKILELILLLGNYMNSGSKNEAAFGFEISYLTKLSNTKDADNKQTLLHYLADLVE 865
            .:::.|:|....||..:|.:||::| |:..:|   ||:|||.|:...||..:||:|||::..:|.
Human  1286 IDQLENNKTLGFILSTLLAIGNFLN-GTNAKA---FELSYLEKVPEVKDTVHKQSLLHHVCTMVV 1346

  Fly   866 KKFPDALNFYDDLSHVNKASRVNMDAIQKAMRQMNSAVK----NLETDLQNNKVPQCDDDKFSEV 926
            :.|||:.:.|.::..:.::::|:.|.:|..:.||....|    :|:...::...|     ...:.
Human  1347 ENFPDSSDLYSEIGAITRSAKVDFDQLQDNLCQMERRCKASWDHLKAIAKHEMKP-----VLKQR 1406

  Fly   927 MGKFAEECRQQVDVLGKMQLQMEKLYKDLSEYYAFDPSKYTMEEFFADIKTFKDAFQAAHNDNVR 991
            |.:|.::|.:::.:|..:..::...:.....:....|  |.:.|  .:|..|           .|
Human  1407 MSEFLKDCAERIIILKIVHRRIINRFHSFLLFMGHPP--YAIRE--VNINKF-----------CR 1456

  Fly   992 VREE--LE---KKRRLQEAREQSAREQQERQQRKKAVVDMD---------------APQTQ-EGV 1035
            :..|  ||   .:.|:.:.:::.|..::..:.|.|.:.|.|               ||.:| :|:
Human  1457 IISEFALEYRTTRERVLQQKQKRANHRERNKTRGKMITDTDEEEEVESGKFSGSSPAPPSQPQGL 1521

  Fly  1036 M--------DSLLEALQTGS--------AFGQRNRQARRQRPA------GAERRAQLSRS----- 1073
            .        :::...|:|.|        |.|.|.| :|..|.:      |.:....::..
Human  1522 SYAEDAAEHENMKAVLKTSSPSVEDATPALGVRTR-SRASRGSTSSWTMGTDDSPNVTDDAADEI 1585

  Fly  1074 -----RSRTRVTNGQLMTRE 1088
                 :|.|:|.:.:::.||
Human  1586 MDRIVKSATQVPSQRVVPRE 1605

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dia	NP_001246113.1	Drf_GBD	66..248	CDD:283920
		Drf_FH3	253..453	CDD:283917	5/17 (29%)
		FH2	608..983	CDD:280362	102/393 (26%)
FHOD3	XP_011524491.1	FH2	1095..1466	CDD:280362	107/414 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1924
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810