DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dia and daam2

DIOPT Version :9

Sequence 1:	NP_001246113.1	Gene:	dia / 35340	FlyBaseID:	FBgn0011202	Length:	1098	Species:	Drosophila melanogaster
Sequence 2:	XP_001338908.5	Gene:	daam2 / 798465	ZFINID:	ZDB-GENE-070709-1	Length:	1095	Species:	Danio rerio

Alignment Length:	1095	Identity:	307/1095 - (28%)
Similarity:	519/1095 - (47%)	Gaps:	136/1095 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    73 ELDAKFLEIIEDMNIPKDKREPLLAKSKEERQKMIMWHLKGKNSLERSANSRFEKPIDYVEYLQN 137
            ||.|:|.|:::|:::....||.:.|...|::.::.....|.:....:.|.|   .|..|::.:.:
Zfish    47 ELHARFSELVDDLDLTDKNREAMFALPAEKKWQIYCSKKKEQEDPNKLATS---WPDYYIDRINS 108

  Fly   138 ----------GEHSTHKVYQCVESLRVALTSNPISWIKEF-GVAGIGTIEKLLARSKNNASYEKI 191
                      .|.......:.||.|:.||.:.|:.::..| .:.|:..:...|.......|..:|
Zfish   109 MAAMQTLFAFDEAEIEMRNKVVEDLKTALRTQPMRFVTRFIELDGLTCLLTFLRSMDYETSESRI 173

  Fly   192 EFEAIRCLKAIMNNTWG-LNVVLNPDQHSVVLLLAQSLDPRKPQTMCEALKLLASFCIVYERNGY 255
            ....|.|:||:|||:.| .:|:.:|..   :..::|||.....:|....|::|.:.|:|  .:|:
Zfish   174 HTSIIGCIKALMNNSQGRAHVLAHPQS---INTISQSLHQDNIKTKVAVLEILGAVCLV--PDGH 233

  Fly   256 EKVLRAITTIAATSFKASE-RFRPIVDALFAS-----DQQDPKRDLACHSLIFINTLTNT---PT 311
            :|||:|:...  ..|.|.. ||:.:::.|..|     |:.:.|..:    :.|||.:.|.   ..
Zfish   234 KKVLQAMAHY--QKFAAERTRFQSLLNGLDRSTGHYRDEVNLKTAI----MSFINAMLNAGVGEE 292

  Fly   312 DLNFRLHLRCEIMRMGLYDRLDEFTKIVEASNNENLQQHFKIFNEIREDDFEEFVQRFDNVTFNM 376
            .:.||||||.|.:.:|:...:::    :.|.:|..|.:|...|..:|.:|..|..:|||::..:.
Zfish   293 SIEFRLHLRYEFLMLGIQPVIEK----LRAHDNATLDRHLDFFEMVRNEDELELAKRFDSMHVDT 353

  Fly   377 DDATDCFDVLKNLVTDTTSEPYFLSILQHLL---YIRDDFYFRPAYYQLIEECISQIVFHKGYCD 438
            ..|...|:::|..::.|.:.|:.||||||.|   |..|....:  .:||::..:.|||..    |
Zfish   354 KSAGQMFELIKKKLSHTDAYPHLLSILQHCLKMPYKHDAGSIQ--QWQLLDRILQQIVLQ----D 412

  Fly   439 PNFEN------RNFNIDT---SLLLDDIVEKAKAKESKRSEEYEKKIEQLESAKQEAEAKAAHLE 494
            .|.||      .|||:..   .|:.::.|::.:.:..|..:|:.:.:.:||...:|.|.|....|
Zfish   413 ENGENPDVSPLENFNVRNIIKMLVNENEVKQWRDQAEKFRKEHVELMTRLERKDRECETKTQEKE 477

  Fly   495 ---------------EKVKLMEAN----------------GVAAPSPNKLPKVNIPMPPPPPG-- 526
                           |.|:|..|.                ||..|.|:.||  ..|||||||.
Zfish   478 DMMKTLNKMKDKLQREGVELRSAKEQVLDMSSRISDISYVGVPLPFPHPLP--GSPMPPPPPSPP 540

  Fly   527 ---GGGA---PPPPPPPMPGRAGGGPPPPPP--PPMPG--RAGGPPPPPPPPGMGGPPPPPMPGM 581
               ||..   |||||||.|......||||||  ||:|.  ....||||||||..|.|.|||
Zfish   541 IMLGGSPLLFPPPPPPPPPPLLHPPPPPPPPLLPPLPPSFAFSSPPPPPPPPSFGCPQPPP---- 601

  Fly   582 MRPGGGPP-----PPPMMMGPMVPVLPHGLKPKKKWDVKNPMKRANWKAIVPAKMSDKAFWVKCQ 641
                |.||     ||    ||.........:.|.......|:|..||..:...:::| ..|....
Zfish   602 ----GAPPIFSGIPP----GPASNSSTTSPQTKSIPQPSQPLKSFNWSKLGGNEITD-TIWYGID 657

  Fly   642 EDKLAQDDFLAELAVKFSSKPVKKEQKDAVDKPTTLTKKNVDLRVLDSKTAQNLAIMLGGSLKHL 706
            :.:..:...|.::...||:...::::..::|......:|..:|.|:|.:.|||..|:| ..|| :
Zfish   658 DRRAFKVLDLKDIEKMFSAYQRQQKETGSMDDLNLSARKVKELSVIDGRRAQNCVILL-SKLK-M 720

  Fly   707 SYEQIKICLLRCD-TDILSSNILQQLIQYLPPPEHLKRLQEIKAKGEPLPPIEQFAATIGEIKRL 770
            |.|::|..:|..| .:.|:.::|:||::::|....:..|:|.|.:.|.:...::|...:..|...
Zfish   721 SNEELKRAVLEMDEREELAKDMLEQLLKFVPEKSDMDLLEEHKHELERMARADRFLFEMSRIDHY 785

  Fly   771 SPRLHNLNFKLTYADMVQDIKPDIVAGTAACEEIRNSKKFSKILELILLLGNYMNSGSKNEAAFG 835
            ..||.:|.||..:||.:.:.||...|...|..|:..||...::||::|..||:||.|.:.. |:|
Zfish   786 QQRLQSLFFKKKFADRLAETKPKAEAILCASREVMRSKLLRQVLEVVLAFGNFMNKGQRGN-AYG 849

  Fly   836 FEISYLTKLSNTKDA-DNKQTLLHYLADLVEKKFPDALNFYDDLSHVNKASRVNMDAIQKAMRQM 899
            |::|.|.|:.:||.: |...|:||||..:.||.:||.|:...||..|::|::||:..::|.:..:
Zfish   850 FKVSSLNKIIDTKSSIDRNITMLHYLIMIFEKNYPDILSIQQDLCSVSEAAKVNLAELEKEVSSI 914

  Fly   900 NSAVKNLETDLQNNKVPQCD-DDKFSEVMGKFAEECRQQVDVLGKMQLQMEKLYKDLSEYYAFDP 963
            .|.:|.||.:|:..:...|| .|||..|:..|..........|.::..:.:..:....:::..:.
Zfish   915 RSGLKALEVELRYQQSRVCDRGDKFVPVVSDFITVASFSFSELEELLNEAKDKFSMALKHFGEEE 979

  Fly   964 SKYTMEEFFADIKTFKDAFQAAHND--NV-RVREELEKKRRLQEAREQSAREQQERQQRKKAVVD 1025
            .:...:|||.....|..:|..|.:|  |: |.:||.|:|.||    |...::|:||::|.|....
Zfish   980 GRMQPDEFFGIFDIFLQSFSEARHDLKNMQRCKEEEERKIRL----EAMLKDQRERERRAKKGTK 1040

  Fly  1026 MDAPQTQEGVMDSLLEALQTGSAFGQRNRQARRQRPAGAERRAQL-SRSRSRTRV 1079
            ....: :.|..|.|:.||::|..| .::.:.:|.|.....:.|.. .|.||.|::
Zfish  1041 GSVSE-EVGEFDDLVSALRSGEVF-DKDSKLKRNRKRSVNQLADAGGRERSVTKM 1093

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dia	NP_001246113.1	Drf_GBD	66..248	CDD:283920	43/186 (23%)
		Drf_FH3	253..453	CDD:283917	62/220 (28%)
		FH2	608..983	CDD:280362	103/377 (27%)
daam2	XP_001338908.5	Drf_GBD	41..228	CDD:283920	43/186 (23%)
		Drf_FH3	231..428	CDD:283917	61/212 (29%)
		FH2	626..999	CDD:280362	103/376 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1204639at2759
OrthoFinder	1	1.000	-	-		FOG0000085
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.920