Protein Alignment dia and daam2

DIOPT Version :10

• Sequence 1: NP_001246113.1
• Gene: dia / 35340
• FlyBaseID: FBgn0011202
• Length: 1098
• Species: Drosophila melanogaster
• Sequence 2: XP_073783764.1
• Gene: daam2 / 798465
• ZFINID: ZDB-GENE-070709-1
• Length: 1103
• Species: Danio rerio
• Alignment Length: 1103
• Identity: 307/1103 - (27%)
• Similarity: 520/1103 - (47%)
• Gaps: 144/1103 - (13%)

  Fly    73 ELDAKFLEIIEDMNIPKDKREPLLAKSKEERQKMIMWHLKGKNSLERSANSRFEKPIDYVEYLQN 137
            ||.|:|.|:::|:::....||.:.|...|::.::.....|.:....:.|.|   .|..|::.:.:
Zfish    47 ELHARFSELVDDLDLTDKNREAMFALPAEKKWQIYCSKKKEQEDPNKLATS---WPDYYIDRINS 108

  Fly   138 ----------GEHSTHKVYQCVESLRVALTSNPISWIKEF-GVAGIGTIEKLLARSKNNASYEKI 191
                      .|.......:.||.|:.||.:.|:.::..| .:.|:..:...|.......|..:|
Zfish   109 MAAMQTLFAFDEAEIEMRNKVVEDLKTALRTQPMRFVTRFIELDGLTCLLTFLRSMDYETSESRI 173

  Fly   192 EFEAIRCLKAIMNNTWG-LNVVLNPDQHSVVLLLAQSLDPRKPQTMCEALKLLASFCIVYERNGY 255
            ....|.|:||:|||:.| .:|:.:|..   :..::|||.....:|....|::|.:.|:|  .:|:
Zfish   174 HTSIIGCIKALMNNSQGRAHVLAHPQS---INTISQSLHQDNIKTKVAVLEILGAVCLV--PDGH 233

  Fly   256 EKVLRAITTIAATSFKASE-RFRPIVDALFAS-----DQQDPKRDLACHSLIFINTLTNT---PT 311
            :|||:|:...  ..|.|.. ||:.:::.|..|     |:.:.|..:    :.|||.:.|.   ..
Zfish   234 KKVLQAMAHY--QKFAAERTRFQSLLNGLDRSTGHYRDEVNLKTAI----MSFINAMLNAGVGEE 292

  Fly   312 DLNFRLHLRCEIMRMGLYDRLDEFTKIVEASNNENLQQHFKIFNEIREDDFEEFVQRFDNVTFNM 376
            .:.||||||.|.:.:|:...:::    :.|.:|..|.:|...|..:|.:|..|..:|||::..:.
Zfish   293 SIEFRLHLRYEFLMLGIQPVIEK----LRAHDNATLDRHLDFFEMVRNEDELELAKRFDSMHVDT 353

  Fly   377 DDATDCFDVLKNLVTDTTSEPYFLSILQHLL---YIRDDFYFRPAYYQLIEECISQIVFHKGYCD 438
            ..|...|:::|..::.|.:.|:.||||||.|   |..|....:  .:||::..:.|||..    |
Zfish   354 KSAGQMFELIKKKLSHTDAYPHLLSILQHCLKMPYKHDAGSIQ--QWQLLDRILQQIVLQ----D 412

  Fly   439 PNFEN------RNFNID-----------TSLLLDDIVEKAKAKESKRSEEYEKKIEQLESAKQEA 486
            .|.||      .|||:.           :.|:.::.|::.:.:..|..:|:.:.:.:||...:|.
Zfish   413 ENGENPDVSPLENFNVRNIIKIYGKRHMSRLVNENEVKQWRDQAEKFRKEHVELMTRLERKDREC 477

  Fly   487 EAKAAHLE---------------EKVKLMEAN----------------GVAAPSPNKLPKVNIPM 520
            |.|....|               |.|:|..|.                ||..|.|:.||  ..||
Zfish   478 ETKTQEKEDMMKTLNKMKDKLQREGVELRSAKEQVLDMSSRISDISYVGVPLPFPHPLP--GSPM 540

  Fly   521 PPPPPG-----GGGA---PPPPPPPMPGRAGGGPPPPPP--PPMPG--RAGGPPPPPPPPGMGGP 573
            |||||.     ||..   |||||||.|......||||||  ||:|.  ....||||||||..|.|
Zfish   541 PPPPPSPPIMLGGSPLLFPPPPPPPPPPLLHPPPPPPPPLLPPLPPSFAFSSPPPPPPPPSFGCP 605

  Fly   574 PPPPMPGMMRPGGGPP-----PPPMMMGPMVPVLPHGLKPKKKWDVKNPMKRANWKAIVPAKMSD 633
            .|||        |.||     ||    ||.........:.|.......|:|..||..:...:::|
Zfish   606 QPPP--------GAPPIFSGIPP----GPASNSSTTSPQTKSIPQPSQPLKSFNWSKLGGNEITD 658

  Fly   634 KAFWVKCQEDKLAQDDFLAELAVKFSSKPVKKEQKDAVDKPTTLTKKNVDLRVLDSKTAQNLAIM 698
             ..|....:.:..:...|.::...||:...::::..::|......:|..:|.|:|.:.|||..|:
Zfish   659 -TIWYGIDDRRAFKVLDLKDIEKMFSAYQRQQKETGSMDDLNLSARKVKELSVIDGRRAQNCVIL 722

  Fly   699 LGGSLKHLSYEQIKICLLRCD-TDILSSNILQQLIQYLPPPEHLKRLQEIKAKGEPLPPIEQFAA 762
            | ..|| :|.|::|..:|..| .:.|:.::|:||::::|....:..|:|.|.:.|.:...::|..
Zfish   723 L-SKLK-MSNEELKRAVLEMDEREELAKDMLEQLLKFVPEKSDMDLLEEHKHELERMARADRFLF 785

  Fly   763 TIGEIKRLSPRLHNLNFKLTYADMVQDIKPDIVAGTAACEEIRNSKKFSKILELILLLGNYMNSG 827
            .:..|.....||.:|.||..:||.:.:.||...|...|..|:..||...::||::|..||:||.|
Zfish   786 EMSRIDHYQQRLQSLFFKKKFADRLAETKPKAEAILCASREVMRSKLLRQVLEVVLAFGNFMNKG 850

  Fly   828 SKNEAAFGFEISYLTKLSNTKDA-DNKQTLLHYLADLVEKKFPDALNFYDDLSHVNKASRVNMDA 891
            .:.. |:||::|.|.|:.:||.: |...|:||||..:.||.:||.|:...||..|::|::||:..
Zfish   851 QRGN-AYGFKVSSLNKIIDTKSSIDRNITMLHYLIMIFEKNYPDILSIQQDLCSVSEAAKVNLAE 914

  Fly   892 IQKAMRQMNSAVKNLETDLQNNKVPQCD-DDKFSEVMGKFAEECRQQVDVLGKMQLQMEKLYKDL 955
            ::|.:..:.|.:|.||.:|:..:...|| .|||..|:..|..........|.::..:.:..:...
Zfish   915 LEKEVSSIRSGLKALEVELRYQQSRVCDRGDKFVPVVSDFITVASFSFSELEELLNEAKDKFSMA 979

  Fly   956 SEYYAFDPSKYTMEEFFADIKTFKDAFQAAHND--NV-RVREELEKKRRLQEAREQSAREQQERQ 1017
            .:::..:..:...:|||.....|..:|..|.:|  |: |.:||.|:|.||    |...::|:||:
Zfish   980 LKHFGEEEGRMQPDEFFGIFDIFLQSFSEARHDLKNMQRCKEEEERKIRL----EAMLKDQRERE 1040

  Fly  1018 QRKKAVVDMDAPQTQEGVMDSLLEALQTGSAFGQRNRQARRQRPAGAERRAQL-SRSRSRTRV 1079
            :|.|........: :.|..|.|:.||::|..| .::.:.:|.|.....:.|.. .|.||.|::
Zfish  1041 RRAKKGTKGSVSE-EVGEFDDLVSALRSGEVF-DKDSKLKRNRKRSVNQLADAGGRERSVTKM 1101

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
dia	NP_001246113.1	Drf_GBD	66..248	CDD:461886	43/186 (23%)
		Drf_FH3	253..453	CDD:461885	62/228 (27%)
		FH2	608..983	CDD:396655	103/377 (27%)
daam2	XP_073783764.1	None