Protein Alignment dia and fmn2a

DIOPT Version :10

• Sequence 1: NP_001246113.1
• Gene: dia / 35340
• FlyBaseID: FBgn0011202
• Length: 1098
• Species: Drosophila melanogaster
• Sequence 2: XP_001333061.5
• Gene: fmn2a / 793321
• ZFINID: ZDB-GENE-101107-1
• Length: 1465
• Species: Danio rerio
• Alignment Length: 1241
• Identity: 279/1241 - (22%)
• Similarity: 453/1241 - (36%)
• Gaps: 338/1241 - (27%)

  Fly     4 KKLGMSRH-EKTKSTGGGLLDSLFGRPSKSKGGT-------ISSGTLAHGGRPVSADNYVVPG-V 59
            :::|...| |.|.....|.| :..|.|.|.:|.:       |.||... ||...|.......| |
Zfish   354 RQVGFEGHVEVTHGPTRGSL-ACEGEPEKLEGASDSKYLNLICSGDTT-GGVITSKLKIESDGKV 416

  Fly    60 EDFEQYIQQLSVAELDAKFLEIIEDMNIPKDKREPLLAKSKEERQKMIMWHLKGKNSLERSANSR 124
            .|.......||....|....:.:.:.|..:|.|....:.|....|.........:::.|...:|.
Zfish   417 ADIPNKADHLSSLSSDYSIQDAVPETNSVQDARAFTHSTSNYSFQDNTGTSTSYESAEEILESSS 481

  Fly   125 FEKPIDYVEYLQNGEHSTHKVYQCVESLRVAL-TSNPISWIK-------------EFGVAGIGTI 175
            ...|::...|..|         ...:||.|.| :||.:|.|.             |..|.|.|.:
Zfish   482 LSSPLEECHYDSN---------SLTQSLEVGLNSSNHMSKINRVIFVPQKSISSVELNVDGDGPV 537

  Fly   176 EKL------LARSKNNASYEKIEFEAIRCLKAIMNNTWGLNVVLNPDQHSVVLLLAQSLDPRKPQ 234
            |::      ..|.|::|:                          :..|.|....|.....||:..
Zfish   538 EEVDRGFSTQPRRKSSAA--------------------------SMTQWSSENFLGSGSRPRRTS 576

  Fly   235 TMCEALKLLASFCIVYERNGYEKVLRAITTIAATSFKASERFRPIVD---------------ALF 284
            :....:|...:.     :..|.|.    ||...||        ||:.               .|.
Zfish   577 SANLGVKPYPTI-----QTSYVKT----TTRQLTS--------PIISPFTTPSPSPMCPRKVGLE 624

  Fly   285 ASDQQDPKR----------------DLACHSLIFINTLTNTPTDLNFRLHLRCEIMRMGLY-DRL 332
            ....|.|.|                .:.||.            :....:|.:.|::..|.. ||.
Zfish   625 FGTGQGPYRAGSWRARRQRSCSIAGPVGCHE------------EWCEVIHDQSELIESGFQTDRS 677

  Fly   333 DEFTKIVE--ASNNENLQQHFKIFNEIREDDFEEFVQRFDNVTFNMDDATDCFDVLKNLVT--DT 393
            .:.|....  .|.:..|::.|..::...:|...:.::||.:...::.......|.::...|  |.
Zfish   678 RQTTSTFPDVFSGSSLLERCFLQWSSSEDDSAMQDIERFCSRILDLGILQPFSDCIREPSTGSDV 742

  Fly   394 TSEPYFLSILQHLLYIRDDFY-FRP---------------------------------------- 417
            |.:|.|         .:|..| :.|
Zfish   743 TDKPTF---------NKDQLYTWAPMGQHDIRTPGRLQRIWPPTLTAAQDGSTGQSGSVLEGSSV 798

  Fly   418 ---AYYQLIEECISQIVFHKGYCDPNFENRNFNIDTSLLLDD--------IVEKAKAKESKRSEE 471
               ...|.|||.:.:|        ...|..|..:|..|...|        .:::.|. ..:|...
Zfish   799 SIQELEQTIEELLEKI--------SEIEKDNHVVDGKLGRKDREVAGFNQTIKQTKV-NGQRVLH 854

  Fly   472 YEKKIEQLESAKQEA---EAKAAHLEEKVKLMEANGVAAPSPNKLP-----------KVNIP--- 519
            :.|.|:  .|..:||   ....:|..:..||.:    :|.||..||           .::.|
Zfish   855 HVKAIQ--TSPVEEAFKFPVPLSHQSQTPKLSD----SATSPMGLPYTCSCQRTTSQPLSTPPPP 913

  Fly   520 -MPPPPPGGGGAPP------PPPPPMPGRAGGGPPP------PPPPPMPGRAGGPPPPPPPPGMG 571
             :|||||..|..||      |||||:||..   |||      |||||:||..  ||||||.|||.
Zfish   914 QLPPPPPLSGMTPPKPTGVIPPPPPLPGFV---PPPPVVGKAPPPPPLPGMV--PPPPPPLPGMA 973

  Fly   572 GPPPPPMPGMMRPGGGPPPPPMMMGPMVPVLPHGLKP-------------------KKKWDVKNP 617
            .|||||.|||..|   |||||...||..|.||.|:.|                   |...:...|
Zfish   974 PPPPPPFPGMTPP---PPPPPPGCGPPPPPLPPGIGPPPPFMGMGPPGMAHESVPLKAVIEPPRP 1035

  Fly   618 MKRANWKAI-VPAKMSDKA--FWVKCQEDKLAQDDFLAELAVKFSSKPVKKEQKDAVDKPTTLTK 679
            ||...|..| :.||...|:  .|...||..:..|:|     |:..:|...||:|..:....|.:|
Zfish  1036 MKPLYWTRIQLHAKKDAKSALVWENVQEPSVDFDEF-----VEMFAKSAVKEKKKPISDTITKSK 1095

  Fly   680 KNVDLRVLDSKTAQNLAIMLGGSLKHLSYEQIKICLLRCDTDILSSNILQQLIQYLPPPEHLKRL 744
            ....:::|.:|.:|.:.|::  |..||..:.|:..:|:.|..::....||.|.:.....|.:.::
Zfish  1096 AKQVVKLLSNKRSQAVGILM--SSLHLDMKDIQNAILKMDCTVVDLETLQALYENRAQKEEMDQI 1158

  Fly   745 Q------EIKAKGEPLPPIEQFAATIGEIKRLSPRLHNLNFKLTYADMVQDIKPDIVAGTAACEE 803
            :      :.|.|.:||...|||...:.|:.:.|.|:..:.|:.|:.:.|..::..:......|..
Zfish  1159 EKHVKSSKDKEKPKPLDKPEQFLLQLSEVPQFSERVFCILFQSTFTECVTSVQRKLETLGRVCTA 1223

  Fly   804 IRNSKKFSKILELILLLGNYMNSGSKNEA-AFGFEISYLTKLSNTKDADNKQTLLHYLADLVEKK 867
            :::.:...:||.|:|..||.||.|:::.. |.||.:..|.||.:.|.:||.|:||.|:.....:.
Zfish  1224 LQSGQAVLQILGLVLAFGNIMNGGNRSRGQADGFSLDILPKLKDVKSSDNSQSLLSYIVAYYLRH 1288

  Fly   868 F-------------PDALNFYDDLSHVNKASRVNMDAIQKAMRQMNSAVKNLET-DLQNNKVPQC 918
            |             |:..:.:       :||::..:..|:.:|::.   |:|.. ..:..||...
Zfish  1289 FDEDAGKETCTYPLPEPQDLF-------QASQMKFEDFQRDLRKLR---KDLNACSAEREKVCNI 1343

  Fly   919 DDDK----FSEVMGKFAEECRQQVDVLGKMQLQMEKLYKDLSEYYAFDPSKYTME---------- 969
            ..|:    |.:.|..|..:.:.::::..|.....::::.:||.:::..|.....|
Zfish  1344 SSDEHLQPFKDKMDDFLTKAKTELELQEKQLTDTQRIFLELSVFFSVKPKAGEKEVSPNTFFTVW 1408

  Fly   970 -EFFADIKTFKDAFQAAHNDNVRVREELEKKRRLQEAREQSAREQQERQQRKKAVVDMDAPQTQE 1033
             ||.:|   ||:.::.            |.|..|||  ...|.|:..:|.|:||..:: .|:...
Zfish  1409 HEFSSD---FKELWKR------------ENKSLLQE--RLKAAEETFKQAREKATYNV-KPKQAS 1455

  Fly  1034 GVMDSL 1039
            |:...|
Zfish  1456 GIKAKL 1461

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
dia	NP_001246113.1	Drf_GBD	66..248	CDD:461886	35/201 (17%)
		Drf_FH3	253..453	CDD:461885	43/279 (15%)
		FH2	608..983	CDD:396655	96/432 (22%)
fmn2a	XP_001333061.5	None