Protein Alignment dia and Daam2

DIOPT Version :10

• Sequence 1: NP_001246113.1
• Gene: dia / 35340
• FlyBaseID: FBgn0011202
• Length: 1098
• Species: Drosophila melanogaster
• Sequence 2: NP_001008232.2
• Gene: Daam2 / 76441
• MGIID: 1923691
• Length: 1115
• Species: Mus musculus
• Alignment Length: 1136
• Identity: 303/1136 - (26%)
• Similarity: 526/1136 - (46%)
• Gaps: 198/1136 - (17%)

  Fly    73 ELDAKFLEIIEDMNIPKDKREPLLAKSKEERQKMIMWHLKGKNSLERSANSRFEKPIDYVEYL-- 135
            ||:.:|.|:::::::....||.:.|...|::.::.....|.:....:.|.|..|..||.:..:
Mouse    47 ELNVRFAELVDELDLTDKNREAVFALPPEKKWQIYCSKRKEQEDPNKLATSWPEYYIDRINAMAA 111

  Fly   136 -----QNGEHSTHKVYQCVESLRVALTSNPISWIKEF-GVAGIGTIEKLLARSKNNASYEKIEFE 194
                 :..:..|.|..|.||.|:.||.:.|:.::..| .:.|:..:...|....:.....:|...
Mouse   112 MQNLYETEDEETDKRNQVVEDLKTALRTQPMRFVTRFIDLEGLTCLLNFLRGMDHTTCESRIHTS 176

  Fly   195 AIRCLKAIMNNTWG-LNVVLNPDQHSVVLLLAQSLDPRKPQTMCEALKLLASFCIVYERNGYEKV 258
            .|.|:||:|||:.| .:|:..|:..|::   ||||.....:|....|::|.:.|:|  ..|::||
Mouse   177 LIGCIKALMNNSQGRAHVLAQPEAISII---AQSLRTENSKTKVAVLEILGAVCLV--PGGHKKV 236

  Fly   259 LRAITTIAATSFKASERFRPIVDALFAS-----DQQDPKRDLACHSLIFINTLTNT---PTDLNF 315
            |:|:....|.:.:.: ||:.:::.|..|     |:.:.|..:    :.|||.:.|.   ..:|.|
Mouse   237 LQAMLHYQAYAAERT-RFQTLLNELDRSLGRYRDEVNLKTAI----MSFINAVLNAGAGEDNLEF 296

  Fly   316 RLHLRCEIMRMGLYDRLDEFTKIVEASNNENLQQHFKIFNEIREDDFEEFVQRFDNVTFNMDDAT 380
            |||||.|.:.:|:...:|:    :....|..|.:|...|..:|.:|..|..:|||.|..:...|:
Mouse   297 RLHLRYEFLMLGIQPVIDK----LRQHENAILDKHLDFFEMVRNEDDLELARRFDMVHIDTKSAS 357

  Fly   381 DCFDVLKNLVTDTTSEPYFLSILQHLL---YIRDDFYFRPAYYQLIEECISQIVF--HKGYCDPN 440
            ..|:::...:..|.:.|..||:|.|.|   |.|:..||:  .:||::..:.|||.  .:| .||:
Mouse   358 QMFELIHKKLKHTEAYPCLLSVLHHCLQMPYKRNGGYFQ--QWQLLDRILQQIVLQDERG-VDPD 419

  Fly   441 ---FENRNF-NIDTSLLLDDIVEKAKAKESKRSEEYEKKIEQLESAKQEAEAKAAHLEEKVK--- 498
               .||.|. ||...|:.::.|::.:.:..|..:|:.:.:.:||..::|.|.|....||.::
Mouse   420 LAPLENFNVKNIVNMLINENEVKQWRDQAEKFRKEHMELMSRLERKERECETKTLEKEEMMRTLN 484

  Fly   499 ------------LMEANG-----VAAPSPNKLPKVNIPMPPPPPGGGGAP------------PPP 534
                        |.:|.|     ||..:.:....|:   .||||||   |            |||
Mouse   485 KMKDKLARESQELRQARGQVAELVARHNESSTGPVS---SPPPPGG---PLTLSSSRTTNDLPPP 543

  Fly   535 PPPMPGRAGGGPPPPPPPPMPGRAGGPPPPP--PPPGMGGPPP--PPMPGMMRPGGGPPPPPMMM 595
            |||:|   ....||||.||:|  .||||.||  ||....||||  .|......|
Mouse   544 PPPLP---FDSCPPPPAPPLP--PGGPPIPPGAPPCFSSGPPPSHDPFSSNEAP----------- 592

  Fly   596 GPMVPVLPHGLKPKKKWDVKNPMKRANWKAIVPAKMSDKAFWVKCQEDKLAQDDFLAELAVKFS- 659
                      |:.|:.....:|:|..||..:...::|. ..|.:..:.::.:...|.:....||
Mouse   593 ----------LRKKRIPQPSHPLKSFNWVKLNEERVSG-TVWNEIDDSQVFRILDLEDFEKMFSA 646

  Fly   660 -------------------------SKPV-----------------------KKEQKDAVDKPTT 676
                                     |:|:                       |||.....|...|
Mouse   647 YQRHQACMQEGPQRERGNVRDGGAASRPLPAVEASAHRTEKASRSMVSATGAKKELGSTEDIYIT 711

  Fly   677 LTKKNVDLRVLDSKTAQNLAIMLGGSLKHLSYEQIKICLLRCD-TDILSSNILQQLIQYLPPPEH 740
             ::|..:|.|:|.:.|||..|:| ..|| ||.::|:..:||.| .:.|:.::|:||::::|....
Mouse   712 -SRKVKELSVIDGRRAQNCIILL-SKLK-LSNDEIRQAILRMDEQEDLAKDMLEQLLKFIPEKSD 773

  Fly   741 LKRLQEIKAKGEPLPPIEQFAATIGEIKRLSPRLHNLNFKLTYADMVQDIKPDIVAGTAACEEIR 805
            :..|:|.|.:.|.:...::|...:..|.....||..|.||..:.:.:.:.||.:.|...|..|:.
Mouse   774 IDLLEEHKHEIERMARADRFLYEMSRIDHYQQRLQALFFKKKFQERLAEAKPKVEAILLASRELT 838

  Fly   806 NSKKFSKILELILLLGNYMNSGSKNEAAFGFEISYLTKLSNTKDA-DNKQTLLHYLADLVEKKFP 869
            .|::..::||::|.:||:||.|.:. .|:||.::.|.|:::||.: |...:|||||..::||.||
Mouse   839 LSQRLKQMLEVVLAIGNFMNKGQRG-GAYGFRVASLNKIADTKSSIDRNISLLHYLIMILEKHFP 902

  Fly   870 DALNFYDDLSHVNKASRVNMDAIQKAMRQMNSAVKNLETDLQNNKVPQCD-DDKFSEVMGKFA-- 931
            |.||...:|.|:::|::||:..::|.:..:...::.:|.:|:..:....| :|||..||..|.
Mouse   903 DILNMPSELKHLSEAAKVNLAELEKEVSILRRGLRAVEVELEYQRHQARDPNDKFVPVMSDFITV 967

  Fly   932 -----EECRQQVDVLGKMQLQMEKLYKDLSEYYAFDPSKYTMEEFFADIKTFKDAFQAAHNDNVR 991
                 .|...|::.      ..:|..|.|: ::....||...:|||....||..||       :.
Mouse   968 SSFSFSELEDQLNE------ARDKFAKALT-HFGEQESKMQPDEFFGIFDTFLQAF-------LE 1018

  Fly   992 VREELEKKRRLQEAREQSAR--------EQQERQQRKKAVVDMDAPQTQEGVMDSLLEALQTGSA 1048
            .|::||..||.:|..|:.||        .::||.||::.|:...|.: :.|..|.|:.||::|..
Mouse  1019 ARQDLEAMRRRKEEDERRARMEFMLKEQREKERWQRQRKVLAGGALE-ESGEFDDLVSALRSGEV 1082

  Fly  1049 FGQRNRQARRQRPAGAERRAQLSRSRSRTRV 1079
            |.:...:.:|.|.....:..:::|.|:..|:
Mouse  1083 FDKDLSKFKRNRKRPGSQVPEVTRERAINRL 1113

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
dia	NP_001246113.1	Drf_GBD	66..248	CDD:461886	45/183 (25%)
		Drf_FH3	253..453	CDD:461885	63/216 (29%)
		FH2	608..983	CDD:396655	112/433 (26%)
Daam2	NP_001008232.2	Drf_GBD	41..228	CDD:461886	45/183 (25%)
		Drf_FH3	231..435	CDD:461885	63/215 (29%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	510..605		38/126 (30%)
		FH2	595..1016	CDD:396655	111/432 (26%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	655..697		2/41 (5%)