DRSC/TRiP Functional Genomics Resources

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Protein Alignment dia and Daam2

DIOPT Version :9

Sequence 1:NP_001246113.1 Gene:dia / 35340 FlyBaseID:FBgn0011202 Length:1098 Species:Drosophila melanogaster
Sequence 2:NP_001008232.2 Gene:Daam2 / 76441 MGIID:1923691 Length:1115 Species:Mus musculus


Alignment Length:1136 Identity:303/1136 - (26%)
Similarity:526/1136 - (46%) Gaps:198/1136 - (17%)


- Green bases have known domain annotations that are detailed below.


  Fly    73 ELDAKFLEIIEDMNIPKDKREPLLAKSKEERQKMIMWHLKGKNSLERSANSRFEKPIDYVEYL-- 135
            ||:.:|.|:::::::....||.:.|...|::.::.....|.:....:.|.|..|..||.:..:  
Mouse    47 ELNVRFAELVDELDLTDKNREAVFALPPEKKWQIYCSKRKEQEDPNKLATSWPEYYIDRINAMAA 111

  Fly   136 -----QNGEHSTHKVYQCVESLRVALTSNPISWIKEF-GVAGIGTIEKLLARSKNNASYEKIEFE 194
                 :..:..|.|..|.||.|:.||.:.|:.::..| .:.|:..:...|....:.....:|...
Mouse   112 MQNLYETEDEETDKRNQVVEDLKTALRTQPMRFVTRFIDLEGLTCLLNFLRGMDHTTCESRIHTS 176

  Fly   195 AIRCLKAIMNNTWG-LNVVLNPDQHSVVLLLAQSLDPRKPQTMCEALKLLASFCIVYERNGYEKV 258
            .|.|:||:|||:.| .:|:..|:..|::   ||||.....:|....|::|.:.|:|  ..|::||
Mouse   177 LIGCIKALMNNSQGRAHVLAQPEAISII---AQSLRTENSKTKVAVLEILGAVCL
V--PGGHKKV 236

  Fly   259 LRAITTIAATSFKASERFRPIVDALFAS-----DQQDPKRDLACHSLIFINTLTNT---PTDLNF 315
            |:|:....|.:.:.: ||:.:::.|..|     |:.:.|..:    :.|||.:.|.   ..:|.|
Mouse   237 LQAMLHYQAYAAERT-RFQTLLNELDRSLGRYRDEVNLKTAI----MSFINAVLNAGAGEDNLEF 296

  Fly   316 RLHLRCEIMRMGLYDRLDEFTKIVEASNNENLQQHFKIFNEIREDDFEEFVQRFDNVTFNMDDAT 380
            |||||.|.:.:|:...:|:    :....|..|.:|...|..:|.:|..|..:|||.|..:...|:
Mouse   297 RLHLRYEFLMLGIQPVIDK----LRQHENAILDKHLDFFEMVRNEDDLELARRFDMVHIDTKSAS 357

  Fly   381 DCFDVLKNLVTDTTSEPYFLSILQHLL---YIRDDFYFRPAYYQLIEECISQIVF--HKGYCDPN 440
            ..|:::...:..|.:.|..||:|.|.|   |.|:..||:  .:||::..:.|||.  .:| .||:
Mouse   358 QMFELIHKKLKHTEAYPCLLSVLHHCLQMPYKRNGGYFQ--QWQLLDRILQQIVLQDERG-VDPD 419

  Fly   441 ---FENRNF-NIDTSLLLDDIVEKAKAKESKRSEEYEKKIEQLESAKQEAEAKAAHLEEKVK--- 498
               .||.|. ||...|:.::.|::.:.:..|..:|:.:.:.:||..::|.|.|....||.::   
Mouse   420 LAPLENFNVKNIVNMLINENEVKQWRDQAEKFRKEHMELMSRLERKERECETKTLEKEEMMRTLN 484

  Fly   499 ------------LMEANG-----VAAPSPNKLPKVNIPMPPPPPGGGGAP------------PPP 534
                        |.:|.|     ||..:.:....|:   .||||||   |            |||
Mouse   485 KMKDKLARESQELRQARGQVAELVARHNESSTGPVS---SPPPPGG---PLTLSSSRTTNDLPPP 543

  Fly   535 PPPMPGRAGGGPPPPPPPPMPGRAGGPPPPP--PPPGMGGPPP--PPMPGMMRPGGGPPPPPMMM 595
            |||:|   ....||||.||:|  .||||.||  ||....||||  .|......|           
Mouse   544 PPPLP---FDSCPPPPAPPLP--PGGPPIPPGAPPCFSSGPPPSHDPFSSNEAP----------- 592

  Fly   596 GPMVPVLPHGLKPKKKWDVKNPMKRANWKAIVPAKMSDKAFWVKCQEDKLAQDDFLAELAVKFS- 659
                      |:.|:.....:|:|..||..:...::|. ..|.:..:.::.:...|.:....|| 
Mouse   593 ----------LRKKRIPQPSHPLKSFNWVKLNEERVSG-TVWNEIDDSQVFRILDLEDFEKMFSA 646

  Fly   660 -------------------------SKPV-----------------------KKEQKDAVDKPTT 676
                                     |:|:                       |||.....|...|
Mouse   647 YQRHQACMQEGPQRERGNVRDGGAASRPLPAVEASAHRTEKASRSMVSATGAKKELGSTEDIYIT 711

  Fly   677 LTKKNVDLRVLDSKTAQNLAIMLGGSLKHLSYEQIKICLLRCD-TDILSSNILQQLIQYLPPPEH 740
             ::|..:|.|:|.:.|||..|:| ..|| ||.::|:..:||.| .:.|:.::|:||::::|....
Mouse   712 -SRKVKELSVIDGRRAQNCIILL-SKLK-LSNDEIRQAILRMDEQEDLAKDMLEQLLKFIPEKSD 773

  Fly   741 LKRLQEIKAKGEPLPPIEQFAATIGEIKRLSPRLHNLNFKLTYADMVQDIKPDIVAGTAACEEIR 805
            :..|:|.|.:.|.:...::|...:..|.....||..|.||..:.:.:.:.||.:.|...|..|:.
Mouse   774 IDLLEEHKHEIERMARADRFLYEMSRIDHYQQRLQALFFKKKFQERLAEAKPKVEAILLASRELT 838

  Fly   806 NSKKFSKILELILLLGNYMNSGSKNEAAFGFEISYLTKLSNTKDA-DNKQTLLHYLADLVEKKFP 869
            .|::..::||::|.:||:||.|.:. .|:||.::.|.|:::||.: |...:|||||..::||.||
Mouse   839 LSQRLKQMLEVVLAIGNFMNKGQRG-GAYGFRVASLNKIADTKSSIDRNISLLHYLIMILEKHFP 902

  Fly   870 DALNFYDDLSHVNKASRVNMDAIQKAMRQMNSAVKNLETDLQNNKVPQCD-DDKFSEVMGKFA-- 931
            |.||...:|.|:::|::||:..::|.:..:...::.:|.:|:..:....| :|||..||..|.  
Mouse   903 DILNMPSELKHLSEAAKVNLAELEKEVSILRRGLRAVEVELEYQRHQARDPNDKFVPVMSDFITV 967

  Fly   932 -----EECRQQVDVLGKMQLQMEKLYKDLSEYYAFDPSKYTMEEFFADIKTFKDAFQAAHNDNVR 991
                 .|...|::.      ..:|..|.|: ::....||...:|||....||..||       :.
Mouse   968 SSFSFSELEDQLNE------ARDKFAKALT-HFGEQESKMQPDEFFGIFDTFLQAF-------LE 1018

  Fly   992 VREELEKKRRLQEAREQSAR--------EQQERQQRKKAVVDMDAPQTQEGVMDSLLEALQTGSA 1048
            .|::||..||.:|..|:.||        .::||.||::.|:...|.: :.|..|.|:.||::|..
Mouse  1019 ARQDLEAMRRRKEEDERRARMEFMLKEQREKERWQRQRKVLAGGALE-ESGEFDDLVSALRSGEV 1082

  Fly  1049 FGQRNRQARRQRPAGAERRAQLSRSRSRTRV 1079
            |.:...:.:|.|.....:..:::|.|:..|:
Mouse  1083 FDKDLSKFKRNRKRPGSQVPEVTRERAINRL 1113

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
diaNP_001246113.1 Drf_GBD 66..248 CDD:283920 45/183 (25%)
Drf_FH3 253..453 CDD:283917 63/216 (29%)
FH2 608..983 CDD:280362 112/433 (26%)
Daam2NP_001008232.2 Drf_GBD 43..228 CDD:283920 45/183 (25%)
Drf_FH3 231..435 CDD:283917 63/215 (29%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 510..605 38/126 (30%)
FH2 595..1016 CDD:280362 111/432 (26%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 655..697 2/41 (5%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D1204639at2759
OrthoFinder 1 1.000 - - FOG0000085
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R3069
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
54.950

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