Protein Alignment dia and FMNL1

DIOPT Version :9

• Sequence 1: NP_001246113.1
• Gene: dia / 35340
• FlyBaseID: FBgn0011202
• Length: 1098
• Species: Drosophila melanogaster
• Sequence 2: XP_006722125.1
• Gene: FMNL1 / 752
• HGNCID: 1212
• Length: 1164
• Species: Homo sapiens
• Alignment Length: 1148
• Identity: 275/1148 - (23%)
• Similarity: 465/1148 - (40%)
• Gaps: 262/1148 - (22%)

  Fly    70 SVAELDAKFLEIIEDMNIPKDKREPLLAKSKEERQKMIMWHLKGKNSLERSANSRFE---KPIDY 131
            :..||:.:|...:..||:|.||.:.|.....|::.::|            ....||:   .|..|
Human    31 AAGELEERFNRALNCMNLPPDKVQLLSQYDNEKKWELI------------CDQERFQVKNPPAAY 83

  Fly   132 VE----YLQNG--------------------EHSTHKVYQCVESLRVALTSNPISWIKEF---GV 169
            ::    |:..|                    :.||    |.:..|..:|.:|.|.|::||   ..
Human    84 IQKLKSYVDTGGVSRKVAADWMSNLGFKRRVQEST----QVLRELETSLRTNHIGWVQEFLNEEN 144

  Fly   170 AGIGTIEKLLARSKNNASYEKIEFE---------------------------------------- 194
            .|:..:.:.||.::.:.:|:....:
Human   145 RGLDVLLEYLAFAQCSVTYDMESTDNGASNSEKNKPLEQSVEDLSKGPPSSVPKSRHLTIKCPPS 209

  Fly   195 --------------------------AIRCLKAIMNNTWGLNVVLNPDQHSVVLLLAQSLDPRKP 233
                                      .|.||:||||...|.::|:|  ..:.|..:|.||:.:.|
Human   210 PRLTPAHSRKALRNSRIVSQKDDVHVCIMCLRAIMNYQSGFSLVMN--HPACVNEIALSLNNKNP 272

  Fly   234 QTMCEALKLLASFCIVYERNGYEKVLRAITTIAATSFK----ASERFRPIVDALFASDQQDPKRD 294
            :|....|:|||:.|:|  |.|::.:|.|.     .:||    ...||..::: .|.::..:....
Human   273 RTKALVLELLAAVCLV--RGGHDIILAAF-----DNFKEVCGEQHRFEKLME-YFRNEDSNIDFM 329

  Fly   295 LACHSLIFINTLTNTPTDLNFRLHLRCEIMRMGLYDRLDEFTKIVEASNNENLQQHFKIFNEIRE 359
            :||  :.|||.:.::..::|||:.|:.|...:|    ||.:.:.:..:.::.||...:.:
Human   330 VAC--MQFINIVVHSVENMNFRVFLQYEFTHLG----LDLYLERLRLTESDKLQVQIQAY----- 383

  Fly   360 DDFEEFVQRFDNVTFNMDDATDCFDVLKNLVTDTTSEPYFLSILQHLLYIRDDFYFRPAYYQLIE 424
                     .||:          ||| ..|:.||.::.   ::|:|:..:::.........:..|
Human   384 ---------LDNI----------FDV-GALLEDTETKN---AVLEHMEELQEQVALLTERLRDAE 425

  Fly   425 -ECISQIVFHKGYCDPNFENRNFNIDTSLLLDDIVEKAKAKESKRSEEYEKKIEQLESAKQEAEA 488
             |.:::|    ...:.........::|  |.:...|......|:|..|.||......:.....|.
Human   426 NESMAKI----AELEKQLSQARKELET--LRERFSESTAMGPSRRPPEPEKAPPAAPTRPSALEL 484

  Fly   489 KAAHLEEK--VKLMEANG-----------VAAPSPNKLPKVNIPMPPPPPG-------GGGAPPP 533
            |...||||  ::::...|           ||.||....|...:|...|.|.       ..||.||
Human   485 KVEELEEKGLIRILRGPGDAVSIEILPVAVATPSGGDAPTPGVPTGSPSPDLAPAAEPAPGAAPP 549

  Fly   534 PPPPMPGRAG----------------GGPPPPPPPPMPG-RAGGPPPPPPPPGMGGPPPPPMPGM 581
            ||||:||...                |.|.|||.||:|| ....|||||||||..||.|||.|..
Human   550 PPPPLPGLPSPQEAPPSAPPQAPPLPGSPEPPPAPPLPGDLPPPPPPPPPPPGTDGPVPPPPPPP 614

  Fly   582 MRPGGGPPPPPMMMGPMVPVLPHGLKPKKKWDVKNPMKRANWKAIVPAKMSDKAFWVKCQEDKLA 646
            ..|.||||.   .:|.....|..|:|.||....|..|...||.|:.|::::...| .:..::|:.
Human   615 PPPPGGPPD---ALGRRDSELGPGVKAKKPIQTKFRMPLLNWVALKPSQITGTVF-TELNDEKVL 675

  Fly   647 QDDFLAELAVKFSSKPVKKEQKDAVD----KPTTLTKKNVDLRVLDSKTAQNLAIMLGGSLKHLS 707
            |:..:::...:|.:    |.|..::|    |.....|......::::..|:||||.|...  :|.
Human   676 QELDMSDFEEQFKT----KSQGPSLDLSALKSKAAQKAPSKATLIEANRAKNLAITLRKG--NLG 734

  Fly   708 YEQIKICLLRCDTDILSSNILQQLIQYLPPPEHLKRLQEIKAKGEPLPPI---EQFAATIGEIKR 769
            .|:|...:...|...|..:.|:.|:::||.......:...:.:..|:..:   ::|......|.|
Human   735 AERICQAIEAYDLQALGLDFLELLMRFLPTEYERSLITRFEREQRPMEELSEEDRFMLCFSRIPR 799

  Fly   770 LSPRLHNLNFKLTYADMVQDIKPDIVAGTAACEEIRNSKKFSKILELILLLGNYMNSGSKNEAAF 834
            |..|:..|.|...:.|..|.:.|.:.|..||...|::|.|..:|||::|..|||||| ||..||:
Human   800 LPERMTTLTFLGNFPDTAQLLMPQLNAIIAASMSIKSSDKLRQILEIVLAFGNYMNS-SKRGAAY 863

  Fly   835 GFEISYLTKLSNTKDADNKQTLLHYLADLVEKKFPDALNFYDDLSHVNKASRVNMDAIQKAMRQM 899
            ||.:..|..|...|..|.||||||||..::.:|:|....|:.||..::||..|::|::...:|.:
Human   864 GFRLQSLDALLEMKSTDRKQTLLHYLVKVIAEKYPQLTGFHSDLHFLDKAGSVSLDSVLADVRSL 928

  Fly   900 NSAVKNLETDLQNNKVPQCDDDKFSEVMGKFAEECRQQVDVLGKMQLQMEKLYKDLSEYYAFDPS 964
            ...:     :|...:..:.||   ..|:.:|.......:|.|.......::.::.:.||:..:|.
Human   929 QRGL-----ELTQREFVRQDD---CMVLKEFLRANSPTMDKLLADSKTAQEAFESVVEYFGENPK 985

  Fly   965 KYTMEEFFADIKTFKDAFQAAHNDNVRVREELEKKRRLQEAREQS--------------AREQQ- 1014
            ..:...||:....|..|::.|..:    .|:.:|:...|||...:              ||..|
Human   986 TTSPGLFFSLFSRFIKAYKKAEQE----VEQWKKEAAAQEAGADTPGKGEPPAPKSPPKARRPQM 1046

  Fly  1015 ------ERQQRKKAVVDMDAPQTQEGVMDSLLEALQTGSAFGQ 1051
                  :|:|:|:       |...|...|..:|.:.||....:
Human  1047 DLISELKRRQQKE-------PLIYESDRDGAIEDIITGKGLAR 1082

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
dia	NP_001246113.1	Drf_GBD	66..248	CDD:283920	51/273 (19%)
		Drf_FH3	253..453	CDD:283917	37/204 (18%)
		FH2	608..983	CDD:280362	101/381 (27%)
FMNL1	XP_006722125.1	Drf_GBD	34..287	CDD:283920	51/270 (19%)
		Drf_FH3	290..>439	CDD:283917	36/192 (19%)
		FH2	639..1004	CDD:280362	101/380 (27%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000085
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3069
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.940