Protein Alignment dia and fhdc1

DIOPT Version :10

• Sequence 1: NP_001246113.1
• Gene: dia / 35340
• FlyBaseID: FBgn0011202
• Length: 1098
• Species: Drosophila melanogaster
• Sequence 2: XP_002933539.2
• Gene: fhdc1 / 734113
• XenbaseID: XB-GENE-983433
• Length: 1117
• Species: Xenopus tropicalis
• Alignment Length: 597
• Identity: 157/597 - (26%)
• Similarity: 264/597 - (44%)
• Gaps: 97/597 - (16%)

  Fly   513 LPKVNIPMPPPPPGGGGAPPPPPPPMPGRAGGGPPPPPPPPMPGRAGGPPPPPPPPGMGGPPPPP 577
            :.::.:..||||      ||.||||        ||||||||:|.:  ..|||||.|  |.|||||
 Frog    22 ITELMVEQPPPP------PPQPPPP--------PPPPPPPPLPFQ--NVPPPPPLP--GAPPPPP 68

  Fly   578 MPGMMRPGGGPPPPPMMMGPMVPVLPHGLKPKKKWDVKNPMKRANWKAIVPAKMSDK-AFWVKCQ 641
            :|..:  |.|                ||...|     :|.|:...||.|...::..| ..|....
 Frog    69 LPHQV--GNG----------------HGNNSK-----RNRMRSFFWKTIPEEQVRGKNNIWTMAA 110

  Fly   642 EDKLAQDD--FLAELAVKFSSKPVKKEQKDAVDK-----PTTLTKKNVDLRVLDSKTAQNLAIML 699
            :.:..|.|  .:.||   |..   |:|.:..:.|     .::..:...::.:||||.:.|:.|.|
 Frog   111 KQQQYQIDTKTIEEL---FGQ---KEEPRSGLIKAKGNLKSSFREAKEEVSLLDSKRSMNIGIFL 169

  Fly   700 GGSLKHLSYEQI--KICLLRCDTDILSSNILQQLIQYLPPPEHLKRLQEIKAKGEPLPPIEQFAA 762
            ....|  |.|:|  .|...||  |:.....||:|::..|..|.:|:|:....:...|...:.|..
 Frog   170 KQFKK--STEEIIGDIREGRC--DLYGPEPLQELLKLSPESEEIKKLKAFSGEVAKLSLADTFMY 230

  Fly   763 TIGEIKRLSPRLHNLNFKLTYADMVQDIKPDIVAGTAACEEIRNSKKFSKILELILLLGNYMNSG 827
            .:.::...|.|:..:..:..:......:|.|:.....|.:|:.:.::...||.|:|..||.||:|
 Frog   231 LLIQVPNYSLRIEAMVLRKEFGSCHSALKNDMTVIRVATKELMSCEQLHSILFLVLQAGNIMNAG 295

  Fly   828 SKNEAAFGFEISYLTKLSNTKDADNKQTLLHYLADLVEKKFPDALNFYDDLSHVNKASRVNMDAI 892
            .....|.||::|.|.:|::||.......|||::|...:||....|.|.:.|..|.:|:|:::|.:
 Frog   296 GYAGNAVGFKLSSLLRLADTKANKPGMNLLHFVALEAQKKDVSLLTFSEKLPSVGEAARLSIDNM 360

  Fly   893 QKAMRQMNSAVKNLETDLQNNKVPQCDDDKFSEVMGKFAEECRQQVDVLGKMQLQMEKLYKDLSE 957
            :...:.:::..|:::..::  |.|:     ..:.|..|.::..:.:..|..::.:::|....|.:
 Frog   361 EAEFKSLSTKTKSIKDQIK--KEPE-----LYKQMEDFLKDAVKDLKDLESLRAEIKKECHTLID 418

  Fly   958 YYAFDPSKYTMEEFFADIKTFKDAFQAAHNDNVRVRE-----------ELEKKRRLQEAREQS-- 1009
            ::..|.....::|.|...:.|.|.|..|..:| |.||           |||:|||...|.|.:
 Frog   419 FFCEDKETMKLDECFQIFRDFCDKFNKAVKEN-REREIQDLRKQKKLNELEQKRRSWVASENANF 482

  Fly  1010 AREQQERQQRKKAVVDMDAPQTQEGVMDSLLEALQTGSAFGQRNRQARRQR---PAGAERRAQLS 1071
            .|...|.        |::. .|:.|:.|.|.:..|:..   .||...||.|   ...|:|..|:.
 Frog   483 GRSSSEN--------DVEI-LTKAGLEDFLQQRPQSSL---NRNSSTRRSRLSLGVAADRELQMY 535

  Fly  1072 RSRSRTRVTNGQ 1083
            ...|:...|..:
 Frog   536 LGASQVEETTSK 547

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
dia	NP_001246113.1	Drf_GBD	66..248	CDD:461886
		Drf_FH3	253..453	CDD:461885
		FH2	608..983	CDD:396655	89/384 (23%)
fhdc1	XP_002933539.2	FH2	82..444	CDD:396655	89/383 (23%)
		ActA	914..>1097	CDD:282861