DRSC/TRiP Functional Genomics Resources

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Protein Alignment dia and Fmnl2

DIOPT Version :9

Sequence 1:NP_001246113.1 Gene:dia / 35340 FlyBaseID:FBgn0011202 Length:1098 Species:Drosophila melanogaster
Sequence 2:XP_006498393.1 Gene:Fmnl2 / 71409 MGIID:1918659 Length:1098 Species:Mus musculus


Alignment Length:1223 Identity:296/1223 - (24%)
Similarity:501/1223 - (40%) Gaps:335/1223 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly    61 DFEQYIQQLSV-----AELDAKFLEIIEDMNIPKDKREPLLAKSKEERQKMIMWHLKGKNSLERS 120
            ||:.:...|.:     .||:.:|..::..||:|.||...|.....|::.::|            .
Mouse    13 DFKAHNVPLKLPMPEPGELEERFAIVLNAMNLPPDKARLLRQYDNEKKWELI------------C 65

  Fly   121 ANSRFE---KPIDYVEYLQN--GEHSTHKVY--------QCVESLRVALTSNPISWIKEF----- 167
            ...||:   .|..|::.|:.  ....|.|.:        |.:..|.::|.:|.|.|::||     
Mouse    66 DQERFQVKNPPHTYIQKLKGYLDPAVTRKKFRRRVQESTQVLRELEISLRTNHIGWVREFLNEEN 130

  Fly   168 -GVAGI-------------------GTIEKLLARSK--------------------NNAS----Y 188
             |:..:                   .|:|..:.:||                    |:.|    :
Mouse   131 KGLDVLVEYLSFAQYAVTFDFESVESTMESTVDKSKPWSRSIEDLHRGSNLPSPVGNSVSRSGRH 195

  Fly   189 EKIEFE----------------------AIRCLKAIMNNTWGLNVVLNPDQHSVVLLLAQSLDPR 231
            ..:.:.                      .|.||:||||..:|.|:|:: ..|: |..:|.||:.:
Mouse   196 SALRYNTLPSRRTLKNSRLVSKKDDVHVCIMCLRAIMNYQYGFNMVMS-HPHA-VNEIALSLNNK 258

  Fly   232 KPQTMCEALKLLASFCIVYERNGYEKVLRAITTIAATSFK----ASERFRPIVDALFASDQQDPK 292
            .|:|....|:|||:.|:|  |.|:|.:|.|.     .:||    ..:||..:::..   ..:|..
Mouse   259 NPRTKALVLELLAAVCLV--RGGHEIILSAF-----DNFKEVCGEKQRFEKLMEHF---RNEDNN 313

  Fly   293 RDLACHSLIFINTLTNTPTDLNFRLHLRCEIMRMGLYDRLDEFTKIVEASNNENLQQHFKIFNEI 357
            .|....|:.|||.:.::..|:|||:||:.|..::|    |||:...::.:.::.||...:.:   
Mouse   314 IDFMVASMQFINIVVHSVEDMNFRVHLQYEFTKLG----LDEYLDKLKHTESDKLQVQIQAY--- 371

  Fly   358 REDDFEEFVQRFDNVTFNMDDATDCFDV--------LKNLVTDTTSEPYFLSILQHLLYIRDDFY 414
                       .|||          |||        .||...:...|     :.:::.::.:.. 
Mouse   372 -----------LDNV----------FDVGALLEDAETKNAALERVEE-----LEENISHLSEKL- 409

  Fly   415 FRPAYYQLIEECISQIV-FHKGYCDPNFE---NRNFNIDTSLLLDDIVEKAKAKES--KRSEEYE 473
                 .....|.:|:|| ..|.....|.|   .|....|.:..:..:.:..|.||.  :|....|
Mouse   410 -----QDTENEAMSKIVELEKQLMQRNKELDVVREIYKDANTQVHTLRKMVKEKEEAIQRQSTLE 469

  Fly   474 KKIEQLE------------------------SAKQEAEAKAAHLEEKVKLMEANGVAAPSPNKLP 514
            |||.:||                        :....:|....:....|.....:|.:.|.|..||
Mouse   470 KKIHELEKQGTIKIQKKGDGDIAILPVMASGTLSTGSELAVGNYVGSVPGATTSGPSVPPPPPLP 534

  Fly   515 ------------KVNIPMPPPPPGGGGAPPPPPPPMPGRAGGGPPPPPPPPMPGRAG----GPPP 563
                        ..:.||.|||      |||||||        ||||||||:||.|.    .||.
Mouse   535 PSSDTSEAAQNGTASPPMSPPP------PPPPPPP--------PPPPPPPPLPGPAAETSPAPPL 585

  Fly   564 PPPPPGMGGPPPPPMPGMMRP----GGGPPPPPMMMGPMVPVLPHGLKPKKKWDVKNPMKRANWK 624
            |||||    |..||:||...|    ..|....|:.:        ..:|.||....|..|...||.
Mouse   586 PPPPP----PSAPPLPGTSSPTVVFNSGLADGPIKL--------FSVKIKKPIKTKFRMPVFNWV 638

  Fly   625 AIVPAKMSDKAFWVKCQEDKLAQDDFLAELAVKFSSKPVKKEQKDAVD----KPTTLTKKNVDLR 685
            |:.|.:::...| .:..::::.:|..:.|....|.:    |.|..|:|    |.....|.:..:.
Mouse   639 ALKPNQINGTVF-NEIDDERILEDLNVDEFEEIFKT----KAQGPAIDLSSSKQKITQKASSKVT 698

  Fly   686 VLDSKTAQNLAIMLGGSLKHLSYEQIKICLLRCDTDILSSNILQQLIQYLPPPEHLKRLQEIKAK 750
            :|::..|:||||.|..:.|  |.::|...:...|...|..:.::.|:::||....:|.|:..:.:
Mouse   699 LLEANRAKNLAITLRKAGK--SADEICKAIHVFDLKTLPVDFVECLMRFLPTENEVKVLRLYERE 761

  Fly   751 GEPLPPI---EQFAATIGEIKRLSPRLHNLNFKLTYADMVQDIKPDIVAGTAACEEIRNSKKFSK 812
            .:||..:   ::|.....:|:||..::..:.|...:.:.:|.:.|.:.|..||...|::|:|..|
Mouse   762 RKPLENLSDEDRFMMQFSKIERLLQKMTIMAFIGNFTESIQMLTPQLHAIIAASVSIKSSQKLKK 826

  Fly   813 ILELILLLGNYMNSGSKNEAAFGFEISYLTKLSNTKDADNKQTLLHYLADLVEKKFPDALNFYDD 877
            |||:||.||||||| ||..|.:||::..|..|.:||..|.|||||||::::|::|:.....||::
Mouse   827 ILEIILALGNYMNS-SKRGAVYGFKLQSLDLLLDTKSTDRKQTLLHYISNVVKEKYQQVTLFYNE 890

  Fly   878 LSHVNKASRVNMDAI----------------QKAMRQMNSAVKNLETDLQN-NKVPQCDDDKFSE 925
            |.:|.||:.|:::.:                :..|...|:.:|  |..|.| .|:.:..:|    
Mouse   891 LHYVEKAAAVSLENVLLDVKELQRGMDLTKREYTMHDHNTLLK--EFLLHNEGKLKKLQED---- 949

  Fly   926 VMGKFAEECRQQVDVLGKMQLQMEKLYKDLSEYYAFDPSKYTMEEFFADIKTFKDAFQAAHNDNV 990
              .|.|::.                 :.|:.:|:..:|.......||.....|..|::.|..:| 
Mouse   950 --AKIAQDA-----------------FDDVVKYFGENPKTTPPSVFFPVFVRFVKAYKQAEEEN- 994

  Fly   991 RVREELEKKRR---LQEAREQSA-REQQE--------RQQRKKAVVDMDAPQT---------QEG 1034
                ||.||:.   :::..||.| .|||:        ::|:::.:.::...|.         ::|
Mouse   995 ----ELRKKQEQALMEKLLEQEALMEQQDAKSPSHKSKRQQQELIAELRRRQVKDNRHVYEGKDG 1055

  Fly  1035 VMDSLLEALQTGSAFGQRNRQARRQRPAGAERRAQLSR-SRSRTRVTNGQLMT 1086
            .::.::..|        ||:..||   |.|.||:...| .....|..||..:|
Mouse  1056 AIEDIITDL--------RNQPYRR---ADAVRRSVRRRFDDQNLRSVNGAEIT 1097

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
diaNP_001246113.1 Drf_GBD 66..248 CDD:283920 55/270 (20%)
Drf_FH3 253..453 CDD:283917 45/215 (21%)
FH2 608..983 CDD:280362 106/398 (27%)
Fmnl2XP_006498393.1 Drf_GBD 23..275 CDD:368864 54/265 (20%)
Drf_FH3 278..475 CDD:368862 53/243 (22%)
FH2 622..973 CDD:366959 102/383 (27%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000085
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R3069
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
43.940

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