DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dia and Inf2

DIOPT Version :9

Sequence 1:	NP_001246113.1	Gene:	dia / 35340	FlyBaseID:	FBgn0011202	Length:	1098	Species:	Drosophila melanogaster
Sequence 2:	XP_030102765.1	Gene:	Inf2 / 70435	MGIID:	1917685	Length:	1285	Species:	Mus musculus

Alignment Length:	1071	Identity:	286/1071 - (26%)
Similarity:	465/1071 - (43%)	Gaps:	209/1071 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   152 LRVALTSNPISWIKEF-GVAGIGTIEKLLARSKNNA----SYEKIEFEAIRCLKAIMNNTWGLNV 211
            ||..|.|:...|:.:| ..:|:..:.:.|||.....    |...::...|.|::|:||:..|:..
Mouse    53 LRKRLESSDGGWMVQFLEQSGLDLLLEALARLSGRGVARISDALLQLTCISCVRAVMNSQQGIEY 117

  Fly   212 VLNPDQHSVVLLLAQSLDPRKPQTMCEALKLLASFCIVYERNGYEKVLRAITTIAATSFK----A 272
            :|:  ....|..|:|:||........:..:|||:.|| |...|:     |:|..|...:|    .
Mouse   118 ILS--NQGYVRQLSQALDTSNVMVKKQVFELLAALCI-YSPEGH-----ALTLDALDHYKMVCSQ 174

  Fly   273 SERFRPIVDALFASDQQDPKRDLACHSLIFINTLTNTPTDLNFRLHLRCEIMRMGLYDRLDEFTK 337
            ..||..|:..|..||.......|    |..||.:...|.||..|..||.|.:.:.|.|.|.....
Mouse   175 QYRFSVIMSELSDSDNVPYVVTL----LSVINAIILGPEDLRSRAQLRSEFIGLQLLDILTRLRD 235

  Fly   338 IVEASNNENLQQHFKIFNEIREDDFEEFVQRFDNVTFNMDDATDCFDVLKNLVTDTTSEPYFLSI 402
            :.:|    :|....:.|.|.:.:|.||..:..|.:  ||:...:.|..|.:.|:.:.:....||:
Mouse   236 LEDA----DLLIQLEAFEEAKAEDEEELQRISDGI--NMNSHQEVFASLFHKVSCSPASAQLLSV 294

  Fly   403 LQHLLYIRDDFYFRPA--YYQLIEECISQIVFHKGYCDPNFENRNFNIDT---SLLLDDIVEKA- 461
            ||.|:::      .||  ..||:.|.:..:|           ||...:.:   :..|:::||:.
Mouse   295 LQGLMHL------EPAGRSGQLLWEALENLV-----------NRAVLLASDAQACTLEEVVERLL 342

  Fly   462 ------------KAKESKRSEEYEK-------------KIE--------------QLESAKQEAE 487
                        ||.:|.::...:.             |:|              .::|:..:..
Mouse   343 SIKGRPRPSPLDKAHKSVQTNSVQNQGSSSQNTTTPTTKVEGQQPVVASPCQHVGSIQSSSVDIA 407

  Fly   488 AKAAHLEEKV--------KLMEANGVAAPSPNKL--PKVNIPMPPPP-------PGGGGA----P 531
            .:...||:.:        .|..:..|..|:|..|  |....|:||||       ||.|..    |
Mouse   408 PQPVALEQCITALPLPTPPLSSSTPVLPPTPPPLPGPGATSPLPPPPPPLPPPLPGSGTTSPPPP 472

  Fly   532 PPPPPPMPGRAGGG-----PPPPPPPPMPGR-AGGPPPPPPPPGMGG------PPPPPMPGMM-- 582
            ||||||:|....|.     ||||||||:||. |..||||||.|.:..      |||||:|||.
Mouse   473 PPPPPPLPPPLPGSGTISPPPPPPPPPLPGTGAVSPPPPPPLPSLPDSHKTQPPPPPPLPGMCPV 537

  Fly   583 -------RPGGGPPPPPM-------MMGP----MVPVLPHGLKPKKKWDVK----NP----MKRA 621
                   |.|..|||||:       |||.    :|..:.|.|  ...|...    ||    ||:.
Mouse   538 PPPPPLPRAGQIPPPPPLPGFSVPSMMGGVEEIIVAQVDHSL--GSAWVPSHRRVNPPTLRMKKL 600

  Fly   622 NWKAIVPAKMSDK--AFWVKCQEDKLA--QDDFLA-ELAVKF--------SSKPVKKEQKDAVDK 673
            ||:.: |:.::.:  :.|........|  :.||.: |....|        |:.|.:||.|
Mouse   601 NWQKL-PSNVARERNSMWATLGSPCTAAVEPDFSSIEQLFSFPTAKPKEPSAAPARKEPK----- 659

  Fly   674 PTTLTKKNVDLRVLDSKTAQNLAIMLGGSLKHL--SYEQIKICLLRCDTDILSSNILQQLIQYLP 736
                     ::..||||.:.||.|.    ||..  |.|::...:...||......:|:||::.||
Mouse   660 ---------EVTFLDSKKSLNLNIF----LKQFKCSNEEVTSMIQAGDTSKFDVEVLKQLLKLLP 711

  Fly   737 PPEHLKRLQEIKAKGEPLPPIEQFAATIGEIKRLSPRLHNLNFKLTYADMVQDIKPDIVAGTAAC 801
            ....::.|:....:...|...:||...:.:|.....|:..:......|.::..::|.......||
Mouse   712 EKHEIENLRAFTEERAKLSNADQFYVLLLDIPCYPLRVECMMLCEGTAIVLDMVRPKAQLVLTAC 776

  Fly   802 EEIRNSKKFSKILELILLLGNYMNSGSKNEAAFGFEISYLTKLSNTKDADNKQTLLHYLADLVEK 866
            |.:..|::.....:|||.:||::|.||....|.||:||.|.||:.||...::.||||::.:.|||
Mouse   777 ESLLTSQRLPVFCQLILKIGNFLNYGSHTGDADGFKISTLLKLTETKSQQSRVTLLHHVLEEVEK 841

  Fly   867 KFPDALNFYDDLSHVNKASRVNMDAIQKAMRQMNSAVKNLETDLQ-NNKVPQCDDDKFSEVMGKF 930
            ..||.|....||...::|:.:|::.|.      :.|..||:..|: ..||    .....||..::
Mouse   842 SHPDLLQLSRDLEPPSQAAGINVEIIH------SEASANLKKLLEAERKV----SASIPEVQKQY 896

  Fly   931 AEECRQQVDV---LGKMQLQMEKLYKDLSEYYAFDPSKYTMEEFFADIKTFKDAFQAAHNDNVRV 992
            ||..:..::.   |.|:...:|:...:|::|...||.:.::|:.|:.:|||:|.|..|..:|...
Mouse   897 AERLQASIEASQELDKVFDAIEQKKLELADYLCEDPQQLSLEDTFSTMKTFRDLFTRALKENKDR 961

  Fly   993 REELEK-KRRLQEAREQSAREQQERQQRKKAVVDMDAPQTQEGVMDSLLEALQTG-----SAFGQ 1051
            :|::.| :||.|:..|:.||  :.|.:..|.:......|.:..|:|:||..::.|     :|.|:
Mouse   962 KEQMAKAERRKQQLAEEEAR--RPRDEDGKPIRKGPGKQEEVCVIDALLADIRKGFQLRKTARGR 1024

  Fly  1052 RNRQAR-RQRPAGAERRAQLSRSRSRTRVTN 1081
            .:.:|. |..||...:..:.:.:.:.|:.||
Mouse  1025 GDTEASGRVAPADPPKATEPATASNPTQGTN 1055

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dia	NP_001246113.1	Drf_GBD	66..248	CDD:283920	26/100 (26%)
		Drf_FH3	253..453	CDD:283917	51/208 (25%)
		FH2	608..983	CDD:280362	105/401 (26%)
Inf2	XP_030102765.1	Drf_GBD	<14..152	CDD:368864	26/100 (26%)
		Drf_FH3	156..341	CDD:368862	54/216 (25%)
		FH2	587..951	CDD:388631	104/392 (27%)
		WH2	1005..1020	CDD:128542	4/14 (29%)
		PHA03307	1034..>1278	CDD:223039	5/22 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1204639at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3069
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.950