Protein Alignment dia and Inf2

DIOPT Version :10

• Sequence 1: NP_001246113.1
• Gene: dia / 35340
• FlyBaseID: FBgn0011202
• Length: 1098
• Species: Drosophila melanogaster
• Sequence 2: XP_030102765.1
• Gene: Inf2 / 70435
• MGIID: 1917685
• Length: 1285
• Species: Mus musculus
• Alignment Length: 1071
• Identity: 286/1071 - (26%)
• Similarity: 465/1071 - (43%)
• Gaps: 209/1071 - (19%)

  Fly   152 LRVALTSNPISWIKEF-GVAGIGTIEKLLARSKNNA----SYEKIEFEAIRCLKAIMNNTWGLNV 211
            ||..|.|:...|:.:| ..:|:..:.:.|||.....    |...::...|.|::|:||:..|:..
Mouse    53 LRKRLESSDGGWMVQFLEQSGLDLLLEALARLSGRGVARISDALLQLTCISCVRAVMNSQQGIEY 117

  Fly   212 VLNPDQHSVVLLLAQSLDPRKPQTMCEALKLLASFCIVYERNGYEKVLRAITTIAATSFK----A 272
            :|:  ....|..|:|:||........:..:|||:.|| |...|:     |:|..|...:|    .
Mouse   118 ILS--NQGYVRQLSQALDTSNVMVKKQVFELLAALCI-YSPEGH-----ALTLDALDHYKMVCSQ 174

  Fly   273 SERFRPIVDALFASDQQDPKRDLACHSLIFINTLTNTPTDLNFRLHLRCEIMRMGLYDRLDEFTK 337
            ..||..|:..|..||.......|    |..||.:...|.||..|..||.|.:.:.|.|.|.....
Mouse   175 QYRFSVIMSELSDSDNVPYVVTL----LSVINAIILGPEDLRSRAQLRSEFIGLQLLDILTRLRD 235

  Fly   338 IVEASNNENLQQHFKIFNEIREDDFEEFVQRFDNVTFNMDDATDCFDVLKNLVTDTTSEPYFLSI 402
            :.:|    :|....:.|.|.:.:|.||..:..|.:  ||:...:.|..|.:.|:.:.:....||:
Mouse   236 LEDA----DLLIQLEAFEEAKAEDEEELQRISDGI--NMNSHQEVFASLFHKVSCSPASAQLLSV 294

  Fly   403 LQHLLYIRDDFYFRPA--YYQLIEECISQIVFHKGYCDPNFENRNFNIDT---SLLLDDIVEKA- 461
            ||.|:::      .||  ..||:.|.:..:|           ||...:.:   :..|:::||:.
Mouse   295 LQGLMHL------EPAGRSGQLLWEALENLV-----------NRAVLLASDAQACTLEEVVERLL 342

  Fly   462 ------------KAKESKRSEEYEK-------------KIE--------------QLESAKQEAE 487
                        ||.:|.::...:.             |:|              .::|:..:..
Mouse   343 SIKGRPRPSPLDKAHKSVQTNSVQNQGSSSQNTTTPTTKVEGQQPVVASPCQHVGSIQSSSVDIA 407

  Fly   488 AKAAHLEEKV--------KLMEANGVAAPSPNKL--PKVNIPMPPPP-------PGGGGA----P 531
            .:...||:.:        .|..:..|..|:|..|  |....|:||||       ||.|..    |
Mouse   408 PQPVALEQCITALPLPTPPLSSSTPVLPPTPPPLPGPGATSPLPPPPPPLPPPLPGSGTTSPPPP 472

  Fly   532 PPPPPPMPGRAGGG-----PPPPPPPPMPGR-AGGPPPPPPPPGMGG------PPPPPMPGMM-- 582
            ||||||:|....|.     ||||||||:||. |..||||||.|.:..      |||||:|||.
Mouse   473 PPPPPPLPPPLPGSGTISPPPPPPPPPLPGTGAVSPPPPPPLPSLPDSHKTQPPPPPPLPGMCPV 537

  Fly   583 -------RPGGGPPPPPM-------MMGP----MVPVLPHGLKPKKKWDVK----NP----MKRA 621
                   |.|..|||||:       |||.    :|..:.|.|  ...|...    ||    ||:.
Mouse   538 PPPPPLPRAGQIPPPPPLPGFSVPSMMGGVEEIIVAQVDHSL--GSAWVPSHRRVNPPTLRMKKL 600

  Fly   622 NWKAIVPAKMSDK--AFWVKCQEDKLA--QDDFLA-ELAVKF--------SSKPVKKEQKDAVDK 673
            ||:.: |:.::.:  :.|........|  :.||.: |....|        |:.|.:||.|
Mouse   601 NWQKL-PSNVARERNSMWATLGSPCTAAVEPDFSSIEQLFSFPTAKPKEPSAAPARKEPK----- 659

  Fly   674 PTTLTKKNVDLRVLDSKTAQNLAIMLGGSLKHL--SYEQIKICLLRCDTDILSSNILQQLIQYLP 736
                     ::..||||.:.||.|.    ||..  |.|::...:...||......:|:||::.||
Mouse   660 ---------EVTFLDSKKSLNLNIF----LKQFKCSNEEVTSMIQAGDTSKFDVEVLKQLLKLLP 711

  Fly   737 PPEHLKRLQEIKAKGEPLPPIEQFAATIGEIKRLSPRLHNLNFKLTYADMVQDIKPDIVAGTAAC 801
            ....::.|:....:...|...:||...:.:|.....|:..:......|.::..::|.......||
Mouse   712 EKHEIENLRAFTEERAKLSNADQFYVLLLDIPCYPLRVECMMLCEGTAIVLDMVRPKAQLVLTAC 776

  Fly   802 EEIRNSKKFSKILELILLLGNYMNSGSKNEAAFGFEISYLTKLSNTKDADNKQTLLHYLADLVEK 866
            |.:..|::.....:|||.:||::|.||....|.||:||.|.||:.||...::.||||::.:.|||
Mouse   777 ESLLTSQRLPVFCQLILKIGNFLNYGSHTGDADGFKISTLLKLTETKSQQSRVTLLHHVLEEVEK 841

  Fly   867 KFPDALNFYDDLSHVNKASRVNMDAIQKAMRQMNSAVKNLETDLQ-NNKVPQCDDDKFSEVMGKF 930
            ..||.|....||...::|:.:|::.|.      :.|..||:..|: ..||    .....||..::
Mouse   842 SHPDLLQLSRDLEPPSQAAGINVEIIH------SEASANLKKLLEAERKV----SASIPEVQKQY 896

  Fly   931 AEECRQQVDV---LGKMQLQMEKLYKDLSEYYAFDPSKYTMEEFFADIKTFKDAFQAAHNDNVRV 992
            ||..:..::.   |.|:...:|:...:|::|...||.:.::|:.|:.:|||:|.|..|..:|...
Mouse   897 AERLQASIEASQELDKVFDAIEQKKLELADYLCEDPQQLSLEDTFSTMKTFRDLFTRALKENKDR 961

  Fly   993 REELEK-KRRLQEAREQSAREQQERQQRKKAVVDMDAPQTQEGVMDSLLEALQTG-----SAFGQ 1051
            :|::.| :||.|:..|:.||  :.|.:..|.:......|.:..|:|:||..::.|     :|.|:
Mouse   962 KEQMAKAERRKQQLAEEEAR--RPRDEDGKPIRKGPGKQEEVCVIDALLADIRKGFQLRKTARGR 1024

  Fly  1052 RNRQAR-RQRPAGAERRAQLSRSRSRTRVTN 1081
            .:.:|. |..||...:..:.:.:.:.|:.||
Mouse  1025 GDTEASGRVAPADPPKATEPATASNPTQGTN 1055

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
dia	NP_001246113.1	Drf_GBD	66..248	CDD:461886	26/100 (26%)
		Drf_FH3	253..453	CDD:461885	51/208 (25%)
		FH2	608..983	CDD:396655	105/401 (26%)
Inf2	XP_030102765.1	Drf_GBD	<8..152	CDD:461886	26/100 (26%)
		Drf_FH3	156..341	CDD:461885	54/216 (25%)
		FH2	587..951	CDD:418645	104/392 (27%)
		WH2_INF2	997..1026	CDD:409204	8/28 (29%)
		actin-binding sequence	1017..1020	CDD:409204	0/2 (0%)
		PHA03307	1034..>1278	CDD:223039	5/22 (23%)