DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment dia and INF2

DIOPT Version :9

Sequence 1:NP_001246113.1 Gene:dia / 35340 FlyBaseID:FBgn0011202 Length:1098 Species:Drosophila melanogaster
Sequence 2:NP_071934.3 Gene:INF2 / 64423 HGNCID:23791 Length:1249 Species:Homo sapiens


Alignment Length:1014 Identity:262/1014 - (25%)
Similarity:437/1014 - (43%) Gaps:146/1014 - (14%)


- Green bases have known domain annotations that are detailed below.


  Fly   152 LRVALTSNPISWIKEF-GVAGIGTIEKLLARSKNNA----SYEKIEFEAIRCLKAIMNNTWGLNV 211
            ||..|..:...|:.:| ..:|:..:.:.|||.....    |...::...:.|::|:||:..|:..
Human    53 LRKRLEGSDGGWMVQFLEQSGLDLLLEALARLSGRGVARISDALLQLTCVSCVRAVMNSRQGIEY 117

  Fly   212 VLNPDQHSVVLLLAQSLDPRKPQTMCEALKLLASFCIVYERNGYEKVLRAI---TTIAATSFKAS 273
            :|:  ....|..|:|:||........:..:|||:.|| |...|:...|.|:   .|:.:..:   
Human   118 ILS--NQGYVRQLSQALDTSNVMVKKQVFELLAALCI
-YSPEGHVLTLDALDHYKTVCSQQY--- 176

  Fly   274 ERFRPIVDALFASDQQDPKRDLACHSLIFINTLTNTPTDLNFRLHLRCEIMRMGLYDRLDEFTKI 338
             ||..:::.|..||.......|    |..||.:...|.||..|..||.|.:.:.|.|.|.....:
Human   177 -RFSIVMNELSGSDNVPYVVTL----LSVINAVILGPEDLRARTQLRNEFIGLQLLDVLARLRDL 236

  Fly   339 VEASNNENLQQHFKIFNEIREDDFEEFVQRFDNVTFNMDDATDCFDVLKNLVTDTTSEPYFLSIL 403
            .:|    :|....:.|.|.:.:|.||.::....|  :|....:.|..|.:.|:.:......||:|
Human   237 EDA----DLLIQLEAFEEAKAEDEEELLRVSGGV--DMSSHQEVFASLFHKVSCSPVSAQLLSVL 295

  Fly   404 QHLLYIRDDFYFRPAYYQLIEECISQIVFHKGYCDPNFENRNFNIDTSLLLDDIVEK-------- 460
            |.||::..........::.:|..:::.|.......            ...|:::||:        
Human   296 QGLLHLEPTLRSSQLLWEALESLVNRAVLLASDAQ------------ECTLEEVVERLLSVKGRP 348

  Fly   461 -------------AKAKESKRSEEYEKKIEQLESAKQEAEAKAAHLEEKVKLMEANGVAAPSPNK 512
                         |...:|:|....:.......|.:.:..|.||..|........:.:....|..
Human   349 RPSPLVKAHKSVQANLDQSQRGSSPQNTTTPKPSVEGQQPAAAAACEPVDHAQSESILKVSQPRA 413

  Fly   513 L-PKVNIPMPPPP----PGGGGAPPPPPPPMPGRAGG------GPPPPP--------------PP 552
            | .:.:.|.||||    ||....|||||||.|..:.|      .|||||              ||
Human   414 LEQQASTPPPPPPPPLLPGSSAEPPPPPPPPPLPSVGAKALPTAPPPPPLPGLGAMAPPAPPLPP 478

  Fly   553 PMPGRAGG-PPPPPPPPGMGGPPPPP--MPGMMRPGGGPPPPPMMMGP--------------MVP 600
            |:||.... ||||||.||:|.|||||  :|||   |.||||||..:.|              :|.
Human   479 PLPGSCEFLPPPPPPLPGLGCPPPPPPLLPGM---GWGPPPPPPPLLPCTCSPPVAGGMEEVIVA 540

  Fly   601 VLPHGLKPKKKWDVK----NP----MKRANWKAIVPAKMS--DKAFW--VKCQEDKLAQDDFLAE 653
            .:.|||  ...|...    ||    ||:.||:.: |:.::  ..:.|  :...:.:..:.||.: 
Human   541 QVDHGL--GSAWVPSHRRVNPPTLRMKKLNWQKL-PSNVAREHNSMWASLSSPDAEAVEPDFSS- 601

  Fly   654 LAVKFSSKPVKKEQKDAVDKPTTLTKKNVDLRVLDSKTAQNLAIMLGGSLKHL--SYEQIKICLL 716
             ..:..|.|..|.::..:..|.. .|:..::..||:|.:.||.|.    ||..  |.|::...:.
Human   602 -IERLFSFPAAKPKEPTMVAPRA-RKEPKEITFLDAKKSLNLNIF----LKQFKCSNEEVAAMIR 660

  Fly   717 RCDTDILSSNILQQLIQYLPPPEHLKRLQEIKAKGEPLPPIEQFAATIGEIKRLSPRLHNLNFKL 781
            ..||......:|:||::.||....::.|:....:...|...:.|...:..|.....|:..:....
Human   661 AGDTTKFDVEVLKQLLKLLPEKHEIENLRAFTEERAKLASADHFYLLLLAIPCYQLRIECMLLCE 725

  Fly   782 TYADMVQDIKPDIVAGTAACEEIRNSKKFSKILELILLLGNYMNSGSKNEAAFGFEISYLTKLSN 846
            ..|.::..::|......||||.:..|::.....:|||.:||::|.||....|.||:||.|.||:.
Human   726 GAAAVLDMVRPKAQLVLAACESLLTSRQLPIFCQLILRIGNFLNYGSHTGDADGFKISTLLKLTE 790

  Fly   847 TKDADNKQTLLHYLADLVEKKFPDALNFYDDLSHVNKASRVNMDAIQKAMRQMNSAVKN-LETDL 910
            ||...|:.||||::.:..||..||.|....||...::|:.:|::.|:.   :.:|.:|. |||: 
Human   791 TKSQQNRVTLLHHVLEEAEKSHPDLLQLPRDLEQPSQAAGINLEIIRS---EASSNLKKLLETE- 851

  Fly   911 QNNKVPQCDDDKFSEVMGKFAEECRQQVD---VLGKMQLQMEKLYKDLSEYYAFDPSKYTMEEFF 972
              .||    ....:||..::.|..:..:.   .|.::...:|:..::|::|...|..:.::|:.|
Human   852 --RKV----SASVAEVQEQYTERLQASISAFRALDELFEAIEQKQRELADYLCEDAQQLSLEDTF 910

  Fly   973 ADIKTFKDAFQAAHNDNVRVREELEK-KRRLQEAREQSAREQQERQQRKKAVVDMDAPQTQEGVM 1036
            :.:|.|:|.|..|..:|...:|:..| :||.|:..|:.||  :.|.:..|.|......|.:..|:
Human   911 STMKAFRDLFLRALKENKDRKEQAAKAERRKQQLAEEEAR--RPRGEDGKPVRKGPGKQEEVCVI 973

  Fly  1037 DSLLEALQTGSAFGQRNRQARRQRPAGAERRAQLSRSRS 1075
            |:||..::.|  |..|.....|....|..:.|.:...|:
Human   974 DALLADIRKG--FQLRKTARGRGDTDGGSKAASMDPPRA 1010

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
diaNP_001246113.1 Drf_GBD 66..248 CDD:283920 24/100 (24%)
Drf_FH3 253..453 CDD:283917 43/202 (21%)
FH2 608..983 CDD:280362 98/392 (25%)
INF2NP_071934.3 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..29
Drf_GBD <14..152 CDD:283920 24/100 (24%)
Drf_FH3 156..341 CDD:283917 46/210 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 347..489 36/141 (26%)
FH2 554..925 CDD:302999 99/388 (26%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 928..966 11/39 (28%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 988..1076 4/23 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1112..1249
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D1204639at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R3069
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.950

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