Protein Alignment dia and INF2

DIOPT Version :10

• Sequence 1: NP_001246113.1
• Gene: dia / 35340
• FlyBaseID: FBgn0011202
• Length: 1098
• Species: Drosophila melanogaster
• Sequence 2: NP_001413791.1
• Gene: INF2 / 64423
• HGNCID: 23791
• Length: 1268
• Species: Homo sapiens
• Alignment Length: 1014
• Identity: 262/1014 - (25%)
• Similarity: 437/1014 - (43%)
• Gaps: 146/1014 - (14%)

  Fly   152 LRVALTSNPISWIKEF-GVAGIGTIEKLLARSKNNA----SYEKIEFEAIRCLKAIMNNTWGLNV 211
            ||..|..:...|:.:| ..:|:..:.:.|||.....    |...::...:.|::|:||:..|:..
Human    53 LRKRLEGSDGGWMVQFLEQSGLDLLLEALARLSGRGVARISDALLQLTCVSCVRAVMNSRQGIEY 117

  Fly   212 VLNPDQHSVVLLLAQSLDPRKPQTMCEALKLLASFCIVYERNGYEKVLRAI---TTIAATSFKAS 273
            :|:  ....|..|:|:||........:..:|||:.|| |...|:...|.|:   .|:.:..:
Human   118 ILS--NQGYVRQLSQALDTSNVMVKKQVFELLAALCI-YSPEGHVLTLDALDHYKTVCSQQY--- 176

  Fly   274 ERFRPIVDALFASDQQDPKRDLACHSLIFINTLTNTPTDLNFRLHLRCEIMRMGLYDRLDEFTKI 338
             ||..:::.|..||.......|    |..||.:...|.||..|..||.|.:.:.|.|.|.....:
Human   177 -RFSIVMNELSGSDNVPYVVTL----LSVINAVILGPEDLRARTQLRNEFIGLQLLDVLARLRDL 236

  Fly   339 VEASNNENLQQHFKIFNEIREDDFEEFVQRFDNVTFNMDDATDCFDVLKNLVTDTTSEPYFLSIL 403
            .:|    :|....:.|.|.:.:|.||.::....|  :|....:.|..|.:.|:.:......||:|
Human   237 EDA----DLLIQLEAFEEAKAEDEEELLRVSGGV--DMSSHQEVFASLFHKVSCSPVSAQLLSVL 295

  Fly   404 QHLLYIRDDFYFRPAYYQLIEECISQIVFHKGYCDPNFENRNFNIDTSLLLDDIVEK-------- 460
            |.||::..........::.:|..:::.|.......            ...|:::||:
Human   296 QGLLHLEPTLRSSQLLWEALESLVNRAVLLASDAQ------------ECTLEEVVERLLSVKGRP 348

  Fly   461 -------------AKAKESKRSEEYEKKIEQLESAKQEAEAKAAHLEEKVKLMEANGVAAPSPNK 512
                         |...:|:|....:.......|.:.:..|.||..|........:.:....|..
Human   349 RPSPLVKAHKSVQANLDQSQRGSSPQNTTTPKPSVEGQQPAAAAACEPVDHAQSESILKVSQPRA 413

  Fly   513 L-PKVNIPMPPPP----PGGGGAPPPPPPPMPGRAGG------GPPPPP--------------PP 552
            | .:.:.|.||||    ||....|||||||.|..:.|      .|||||              ||
Human   414 LEQQASTPPPPPPPPLLPGSSAEPPPPPPPPPLPSVGAKALPTAPPPPPLPGLGAMAPPAPPLPP 478

  Fly   553 PMPGRAGG-PPPPPPPPGMGGPPPPP--MPGMMRPGGGPPPPPMMMGP--------------MVP 600
            |:||.... ||||||.||:|.|||||  :|||   |.||||||..:.|              :|.
Human   479 PLPGSCEFLPPPPPPLPGLGCPPPPPPLLPGM---GWGPPPPPPPLLPCTCSPPVAGGMEEVIVA 540

  Fly   601 VLPHGLKPKKKWDVK----NP----MKRANWKAIVPAKMS--DKAFW--VKCQEDKLAQDDFLAE 653
            .:.|||  ...|...    ||    ||:.||:.: |:.::  ..:.|  :...:.:..:.||.:
Human   541 QVDHGL--GSAWVPSHRRVNPPTLRMKKLNWQKL-PSNVAREHNSMWASLSSPDAEAVEPDFSS- 601

  Fly   654 LAVKFSSKPVKKEQKDAVDKPTTLTKKNVDLRVLDSKTAQNLAIMLGGSLKHL--SYEQIKICLL 716
             ..:..|.|..|.::..:..|.. .|:..::..||:|.:.||.|.    ||..  |.|::...:.
Human   602 -IERLFSFPAAKPKEPTMVAPRA-RKEPKEITFLDAKKSLNLNIF----LKQFKCSNEEVAAMIR 660

  Fly   717 RCDTDILSSNILQQLIQYLPPPEHLKRLQEIKAKGEPLPPIEQFAATIGEIKRLSPRLHNLNFKL 781
            ..||......:|:||::.||....::.|:....:...|...:.|...:..|.....|:..:....
Human   661 AGDTTKFDVEVLKQLLKLLPEKHEIENLRAFTEERAKLASADHFYLLLLAIPCYQLRIECMLLCE 725

  Fly   782 TYADMVQDIKPDIVAGTAACEEIRNSKKFSKILELILLLGNYMNSGSKNEAAFGFEISYLTKLSN 846
            ..|.::..::|......||||.:..|::.....:|||.:||::|.||....|.||:||.|.||:.
Human   726 GAAAVLDMVRPKAQLVLAACESLLTSRQLPIFCQLILRIGNFLNYGSHTGDADGFKISTLLKLTE 790

  Fly   847 TKDADNKQTLLHYLADLVEKKFPDALNFYDDLSHVNKASRVNMDAIQKAMRQMNSAVKN-LETDL 910
            ||...|:.||||::.:..||..||.|....||...::|:.:|::.|:.   :.:|.:|. |||:
Human   791 TKSQQNRVTLLHHVLEEAEKSHPDLLQLPRDLEQPSQAAGINLEIIRS---EASSNLKKLLETE- 851

  Fly   911 QNNKVPQCDDDKFSEVMGKFAEECRQQVD---VLGKMQLQMEKLYKDLSEYYAFDPSKYTMEEFF 972
              .||    ....:||..::.|..:..:.   .|.::...:|:..::|::|...|..:.::|:.|
Human   852 --RKV----SASVAEVQEQYTERLQASISAFRALDELFEAIEQKQRELADYLCEDAQQLSLEDTF 910

  Fly   973 ADIKTFKDAFQAAHNDNVRVREELEK-KRRLQEAREQSAREQQERQQRKKAVVDMDAPQTQEGVM 1036
            :.:|.|:|.|..|..:|...:|:..| :||.|:..|:.||  :.|.:..|.|......|.:..|:
Human   911 STMKAFRDLFLRALKENKDRKEQAAKAERRKQQLAEEEAR--RPRGEDGKPVRKGPGKQEEVCVI 973

  Fly  1037 DSLLEALQTGSAFGQRNRQARRQRPAGAERRAQLSRSRS 1075
            |:||..::.|  |..|.....|....|..:.|.:...|:
Human   974 DALLADIRKG--FQLRKTARGRGDTDGGSKAASMDPPRA 1010

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
dia	NP_001246113.1	Drf_GBD	66..248	CDD:461886	24/100 (24%)
		Drf_FH3	253..453	CDD:461885	43/202 (21%)
		FH2	608..983	CDD:396655	98/392 (25%)
INF2	NP_001413791.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..29
		Drf_GBD	<8..152	CDD:461886	24/100 (24%)
		Drf_FH3	156..341	CDD:461885	46/210 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	347..489		36/141 (26%)
		FH2	554..920	CDD:418645	97/383 (25%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	928..966		11/39 (28%)
		WH2_INF2	966..995	CDD:409204	9/30 (30%)
		actin-binding sequence	986..989	CDD:409204	1/2 (50%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	988..1076		4/23 (17%)