Protein Alignment dia and Diaph3

DIOPT Version :10

• Sequence 1: NP_001246113.1
• Gene: dia / 35340
• FlyBaseID: FBgn0011202
• Length: 1098
• Species: Drosophila melanogaster
• Sequence 2: NP_062644.1
• Gene: Diaph3 / 56419
• MGIID: 1927222
• Length: 1171
• Species: Mus musculus
• Alignment Length: 1069
• Identity: 406/1069 - (37%)
• Similarity: 624/1069 - (58%)
• Gaps: 62/1069 - (5%)

  Fly    47 RPVSADNYVVPGVED--------FEQYIQQLSVAELDAKFLEIIEDMNIPKDKREPLLAKSKEER 103
            ||.......|.|:.|        .|...:.|..:|:...|.:::||||:.:||:.||..|....:
Mouse    66 RPPLPHLKTVSGISDSSSLSSETMENNPKALPESEVLKLFEKMMEDMNLNEDKKAPLREKDFGIK 130

  Fly   104 QKMIMWHLKGKNSLERSANSRFEKPIDYVEYLQNGEHSTHKVYQCVESLRVALTSNPISWIKEFG 168
            ::|:|.::...:......:||...|.:::..|:.| ::..:::..:|||||:|||:|:||::.||
Mouse   131 KEMVMQYINTASKTGSLRSSRQISPQEFLHELKMG-YTDERLFTYLESLRVSLTSHPVSWVQSFG 194

  Fly   169 VAGIGTIEKLLARSKNNASYEKI----EFEAIRCLKAIMNNTWGLNVVLNPDQHSVVLLLAQSLD 229
            ..|:|.:..:|.:..|....||:    :.:.|:||:|:||..:||..::: |:.| :.|||:::|
Mouse   195 HEGLGLLLDILEKLINGQIQEKVVKKTQHKVIQCLRALMNTQYGLERIMS-DKRS-LSLLAKAMD 257

  Fly   230 PRKPQTMCEALKLLASFCIVYERNGYEKVLRAITTIAATSFKASERFRPIVDALFASDQQDPKRD 294
            ||:|..|.:.:|||::.|||.|.:..|:||.|:|  :|...:..:||..||:.|   ........
Mouse   258 PRQPAMMADVVKLLSAVCIVGEESILEEVLEALT--SAGEERKIDRFFSIVEGL---RHNSVNLQ 317

  Fly   295 LACHSLIFINTLTNTPTDLNFRLHLRCEIMRMGLYDRLDEFTKIVEASNNENLQQHFKIFNEIRE 359
            :||..|  ||.|..:|.||:||||||.|.||.||.:.|.....|    .|:.|....|:|:|.:|
Mouse   318 VACMQL--INALVTSPDDLDFRLHLRNEFMRCGLKEILPNLKGI----KNDGLDIQLKVFDEHKE 376

  Fly   360 DDFEEFVQRFDNVTFNMDDATDCFDVLKNLVTDTTSEPYFLSILQHLLYIRDDFYFRPAYYQLIE 424
            :|..||..|.:::...:|:|:|.:.:|.:.|.:|.:|.:|||||||||.||:|.:.|..|::||:
Mouse   377 EDLSEFFHRLEDIRAELDEASDVYSMLWDTVKETRAEGHFLSILQHLLLIRNDRFIREQYFKLID 441

  Fly   425 ECISQIVFHKGYCDPNFENR-NFNIDTSLLLDDIVEKAKAKE-SKRSEEYEKKIEQLESAKQEAE 487
            ||:||||.|:...||:|..| ..::|.|..:|..:::||..| .:::.|:.||.|:..:..||.:
Mouse   442 ECVSQIVLHRDGTDPDFTYRKRLDLDLSQFVDVCIDQAKLDEWEEKASEHCKKFEKECTDHQETQ 506

  Fly   488 AKAAHLEEKVKLMEANGVAAPSPNKLPKVNIPMPPPPPGGGGAPPPPPPPMPGRAGGGPPPPPPP 552
            |:....|.|:..::|...|..|...      .:||      |...|..|.:.|.||....||.||
Mouse   507 AQLQKREAKINELQAELQAFKSQFG------ALPP------GTKIPLQPSVEGEAGPSALPPAPP 559

  Fly   553 PMPGRAGGPPPPPPPPGMGGPPPPPMPGMMRPGGGPPPPPMMMG-----PMVPV-LPHGLKPKKK 611
            .:.|  |.||||||||    |||||:|||..|.|||.|||..:|     ..:|: ||.||||||:
Mouse   560 ALSG--GVPPPPPPPP----PPPPPLPGMPMPFGGPVPPPPPLGFLGGQSSIPLNLPFGLKPKKE 618

  Fly   612 WDVKNPMKRANWKAIVPAKMSDKAFWVKCQEDKLAQDDFLAELAVKFSSKPVKKEQKDAVDKPTT 676
            :..:..|:|.||..|.|.:||:..||:|..|:|....|.|.:|...|..:..:|...:..|:...
Mouse   619 FKPEISMRRLNWLKIGPNEMSENCFWIKVNENKYENRDLLCKLENTFCCQEKEKRNTNDFDEKKV 683

  Fly   677 LTKKNVDLRVLDSKTAQNLAIMLGGSLKHLSYEQIKICLLRCDTDILSSNILQQLIQYLPPPEHL 741
            :.|:..:|:.||.|.||||:|.|  |...:.||:|:..:|..|...||.:::|.||::||..|.|
Mouse   684 IKKRMKELKFLDPKIAQNLSIFL--SSFRVPYEKIRTMILEVDETQLSESMIQNLIKHLPDEEQL 746

  Fly   742 KRLQEIKAKGEPLPPIEQFAATIGEIKRLSPRLHNLNFKLTYADMVQDIKPDIVAGTAACEEIRN 806
            |.|.:.::....|...||||..:..:|||.|||..:.|||.:.:.|.:|||||:|.:.|||||:.
Mouse   747 KSLSQFRSDYNSLCEPEQFAVVMSNVKRLRPRLSAILFKLQFEEQVNNIKPDIMAVSTACEEIKK 811

  Fly   807 SKKFSKILELILLLGNYMNSGSKNEAAFGFEISYLTKLSNTKDADNKQTLLHYLADLVEKKFPDA 871
            ||.|||:|||:||:|||||:||:|...|||::|.|.||.:||.||.|.||||:|.|:.|:|..|.
Mouse   812 SKGFSKLLELVLLMGNYMNAGSRNAQTFGFDLSSLCKLKDTKSADQKTTLLHFLVDVCEEKHADI 876

  Fly   872 LNFYDDLSHVNKASRVNMDAIQKAMRQMNSAVKNLETDLQNNKVPQCDDDKFSEVMGKFAEECRQ 936
            |:|.|||:|::|||||:::.::|.::||...::.||.:|:....|:...|||...|..|.....:
Mouse   877 LHFVDDLAHLDKASRVSVEMLEKNVKQMGRQLQQLEKNLETFPPPEDLHDKFVIKMSSFVISANE 941

  Fly   937 QVDVLGKMQLQMEKLYKDLSEYYAFDPSKYTMEEFFADIKTFKDAFQAAHNDNVRVREELEKKRR 1001
            |.:.|..:...|.:||:.:..|||.|..|.::||||.|:..|:.:|..|..:|::.||..||::|
Mouse   942 QYEKLSTLLGSMTQLYQSIMGYYAVDMKKVSVEEFFNDLNNFRTSFMLALKENIKKREAAEKEKR 1006

  Fly  1002 LQEAREQSAREQQERQQRKKAVVDMDAPQTQEGVMDSLLEALQTGSAFGQRNRQARRQRPAGAER 1066
            .:.|:|::.:|:.||||.||.:::|.....:.|||||||||||:|:||    |..|::.|...:.
Mouse  1007 ARIAKERAEKERLERQQEKKRLLEMKTEGDETGVMDSLLEALQSGAAF----RDRRKRTPKLKDI 1067

  Fly  1067 RAQLSRSRSR--TRVTNGQLMTREMILNE 1093
            |..||....|  .:|.|.:  .::|.|.|
Mouse  1068 RQSLSPMSQRPVLKVCNHE--NQKMQLTE 1094

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
dia	NP_001246113.1	Drf_GBD	66..248	CDD:461886	59/185 (32%)
		Drf_FH3	253..453	CDD:461885	79/200 (40%)
		FH2	608..983	CDD:396655	154/374 (41%)
Diaph3	NP_062644.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..40
		Nuclear localization signal. /evidence=ECO:0000269|PubMed:19117945	16..39
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	60..95		6/28 (21%)
		Drf_GBD	96..276	CDD:461886	59/182 (32%)
		Drf_FH3	284..471	CDD:461885	79/197 (40%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	532..601		38/80 (48%)
		FH2	615..987	CDD:396655	154/373 (41%)
		Casc1_N	999..>1061	CDD:464947	30/65 (46%)
		Nuclear export signal. /evidence=ECO:0000269|PubMed:19117945	1162..1171