DRSC/TRiP Functional Genomics Resources

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Protein Alignment dia and Diaph3

DIOPT Version :9

Sequence 1:NP_001246113.1 Gene:dia / 35340 FlyBaseID:FBgn0011202 Length:1098 Species:Drosophila melanogaster
Sequence 2:NP_062644.1 Gene:Diaph3 / 56419 MGIID:1927222 Length:1171 Species:Mus musculus


Alignment Length:1069 Identity:406/1069 - (37%)
Similarity:624/1069 - (58%) Gaps:62/1069 - (5%)


- Green bases have known domain annotations that are detailed below.


  Fly    47 RPVSADNYVVPGVED--------FEQYIQQLSVAELDAKFLEIIEDMNIPKDKREPLLAKSKEER 103
            ||.......|.|:.|        .|...:.|..:|:...|.:::||||:.:||:.||..|....:
Mouse    66 RPPLPHLKTVSGISDSSSLSSETMENNPKALPESEVLKLFEKMMEDMNLNEDKKAPLREKDFGIK 130

  Fly   104 QKMIMWHLKGKNSLERSANSRFEKPIDYVEYLQNGEHSTHKVYQCVESLRVALTSNPISWIKEFG 168
            ::|:|.::...:......:||...|.:::..|:.| ::..:::..:|||||:|||:|:||::.||
Mouse   131 KEMVMQYINTASKTGSLRSSRQISPQEFLHELKMG-YTDERLFTYLESLRVSLTSHPVSWVQSFG 194

  Fly   169 VAGIGTIEKLLARSKNNASYEKI----EFEAIRCLKAIMNNTWGLNVVLNPDQHSVVLLLAQSLD 229
            ..|:|.:..:|.:..|....||:    :.:.|:||:|:||..:||..::: |:.| :.|||:::|
Mouse   195 HEGLGLLLDILEKLINGQIQEKVVKKTQHKVIQCLRALMNTQYGLERIMS-DKRS-LSLLAKAMD 257

  Fly   230 PRKPQTMCEALKLLASFCIVYERNGYEKVLRAITTIAATSFKASERFRPIVDALFASDQQDPKRD 294
            ||:|..|.:.:|||::.|||.|.:..|:||.|:|  :|...:..:||..||:.|   ........
Mouse   258 PRQPAMMADVVKLLSAVCIVGEESILEEVLEALT--SAGEERKIDRFFSIVEGL---RHNSVNLQ 317

  Fly   295 LACHSLIFINTLTNTPTDLNFRLHLRCEIMRMGLYDRLDEFTKIVEASNNENLQQHFKIFNEIRE 359
            :||..|  ||.|..:|.||:||||||.|.||.||.:.|.....|    .|:.|....|:|:|.:|
Mouse   318 VACMQL--INALVTSPDDLDFRLHLRNEFMRCGLKEILPNLKGI----KNDGLDIQLKVFDEHKE 376

  Fly   360 DDFEEFVQRFDNVTFNMDDATDCFDVLKNLVTDTTSEPYFLSILQHLLYIRDDFYFRPAYYQLIE 424
            :|..||..|.:::...:|:|:|.:.:|.:.|.:|.:|.:|||||||||.||:|.:.|..|::||:
Mouse   377 EDLSEFFHRLEDIRAELDEASDVYSMLWDTVKETRAEGHFLSILQHLLLIRNDRFIREQYFKLID 441

  Fly   425 ECISQIVFHKGYCDPNFENR-NFNIDTSLLLDDIVEKAKAKE-SKRSEEYEKKIEQLESAKQEAE 487
            ||:||||.|:...||:|..| ..::|.|..:|..:::||..| .:::.|:.||.|:..:..||.:
Mouse   442 ECVSQIVLHRDGTDPDFTYRKRLDLDLSQFVDVCIDQAKLDEWEEKASEHCKKFEKECTDHQETQ 506

  Fly   488 AKAAHLEEKVKLMEANGVAAPSPNKLPKVNIPMPPPPPGGGGAPPPPPPPMPGRAGGGPPPPPPP 552
            |:....|.|:..::|...|..|...      .:||      |...|..|.:.|.||....||.||
Mouse   507 AQLQKREAKINELQAELQAFKSQFG------ALPP------GTKIPLQPSVEGEAGPSALPPAPP 559

  Fly   553 PMPGRAGGPPPPPPPPGMGGPPPPPMPGMMRPGGGPPPPPMMMG-----PMVPV-LPHGLKPKKK 611
            .:.|  |.||||||||    |||||:|||..|.|||.|||..:|     ..:|: ||.||||||:
Mouse   560 ALSG--GVPPPPPPPP----PPPPPLPGMPMPFGGPVPPPPPLGFLGGQSSIPLNLPFGLKPKKE 618

  Fly   612 WDVKNPMKRANWKAIVPAKMSDKAFWVKCQEDKLAQDDFLAELAVKFSSKPVKKEQKDAVDKPTT 676
            :..:..|:|.||..|.|.:||:..||:|..|:|....|.|.:|...|..:..:|...:..|:...
Mouse   619 FKPEISMRRLNWLKIGPNEMSENCFWIKVNENKYENRDLLCKLENTFCCQEKEKRNTNDFDEKKV 683

  Fly   677 LTKKNVDLRVLDSKTAQNLAIMLGGSLKHLSYEQIKICLLRCDTDILSSNILQQLIQYLPPPEHL 741
            :.|:..:|:.||.|.||||:|.|  |...:.||:|:..:|..|...||.:::|.||::||..|.|
Mouse   684 IKKRMKELKFLDPKIAQNLSIFL--SSFRVPYEKIRTMILEVDETQLSESMIQNLIKHLPDEEQL 746

  Fly   742 KRLQEIKAKGEPLPPIEQFAATIGEIKRLSPRLHNLNFKLTYADMVQDIKPDIVAGTAACEEIRN 806
            |.|.:.::....|...||||..:..:|||.|||..:.|||.:.:.|.:|||||:|.:.|||||:.
Mouse   747 KSLSQFRSDYNSLCEPEQFAVVMSNVKRLRPRLSAILFKLQFEEQVNNIKPDIMAVSTACEEIKK 811

  Fly   807 SKKFSKILELILLLGNYMNSGSKNEAAFGFEISYLTKLSNTKDADNKQTLLHYLADLVEKKFPDA 871
            ||.|||:|||:||:|||||:||:|...|||::|.|.||.:||.||.|.||||:|.|:.|:|..|.
Mouse   812 SKGFSKLLELVLLMGNYMNAGSRNAQTFGFDLSSLCKLKDTKSADQKTTLLHFLVDVCEEKHADI 876

  Fly   872 LNFYDDLSHVNKASRVNMDAIQKAMRQMNSAVKNLETDLQNNKVPQCDDDKFSEVMGKFAEECRQ 936
            |:|.|||:|::|||||:::.::|.::||...::.||.:|:....|:...|||...|..|.....:
Mouse   877 LHFVDDLAHLDKASRVSVEMLEKNVKQMGRQLQQLEKNLETFPPPEDLHDKFVIKMSSFVISANE 941

  Fly   937 QVDVLGKMQLQMEKLYKDLSEYYAFDPSKYTMEEFFADIKTFKDAFQAAHNDNVRVREELEKKRR 1001
            |.:.|..:...|.:||:.:..|||.|..|.::||||.|:..|:.:|..|..:|::.||..||::|
Mouse   942 QYEKLSTLLGSMTQLYQSIMGYYAVDMKKVSVEEFFNDLNNFRTSFMLALKENIKKREAAEKEKR 1006

  Fly  1002 LQEAREQSAREQQERQQRKKAVVDMDAPQTQEGVMDSLLEALQTGSAFGQRNRQARRQRPAGAER 1066
            .:.|:|::.:|:.||||.||.:::|.....:.|||||||||||:|:||    |..|::.|...:.
Mouse  1007 ARIAKERAEKERLERQQEKKRLLEMKTEGDETGVMDSLLEALQSGAAF----RDRRKRTPKLKDI 1067

  Fly  1067 RAQLSRSRSR--TRVTNGQLMTREMILNE 1093
            |..||....|  .:|.|.:  .::|.|.|
Mouse  1068 RQSLSPMSQRPVLKVCNHE--NQKMQLTE 1094

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
diaNP_001246113.1 Drf_GBD 66..248 CDD:283920 59/185 (32%)
Drf_FH3 253..453 CDD:283917 79/200 (40%)
FH2 608..983 CDD:280362 154/374 (41%)
Diaph3NP_062644.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..40
Nuclear localization signal. /evidence=ECO:0000269|PubMed:19117945 16..39
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 60..95 6/28 (21%)
Drf_GBD 96..276 CDD:283920 59/182 (32%)
Drf_FH3 284..471 CDD:283917 79/197 (40%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 532..601 38/80 (48%)
FH2 615..987 CDD:280362 154/373 (41%)
Nuclear export signal. /evidence=ECO:0000269|PubMed:19117945 1162..1171
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 323 1.000 Domainoid score I1204
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 732 1.000 Inparanoid score I608
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG52328
OrthoDB 1 1.010 - - D1204639at2759
OrthoFinder 1 1.000 - - FOG0000085
OrthoInspector 1 1.000 - - otm44251
orthoMCL 1 0.900 - - OOG6_101727
Panther 1 1.100 - - O PTHR45691
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R3069
SonicParanoid 1 1.000 - - X420
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
1212.010

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