DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dia and fmn1

DIOPT Version :9

Sequence 1:	NP_001246113.1	Gene:	dia / 35340	FlyBaseID:	FBgn0011202	Length:	1098	Species:	Drosophila melanogaster
Sequence 2:	XP_689569.3	Gene:	fmn1 / 561077	ZFINID:	ZDB-GENE-041001-198	Length:	1365	Species:	Danio rerio

Alignment Length:	1153	Identity:	260/1153 - (22%)
Similarity:	440/1153 - (38%)	Gaps:	306/1153 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 SRHEKTKSTGGGLLDSLFGRPSKSKGGTISSGTLAHGGRPVSADNYVVPGVEDFEQYIQQLSVAE 73
            |...:...|||.:.|  |.|.     ||....:.:|.....:.....:...|..|  .:..:..|
Zfish   361 STSNQKNQTGGEISD--FERI-----GTEEESSTSHDSENKANSEQELEPSEPLE--TEMHTEGE 416

  Fly    74 LDAKFLEIIED----MNIPKDKR-------EPLLAKSK---EERQKMIMWHLKGKNSLERSANSR 124
            ::.:..|.||:    ..:.|:|.       ..||:..|   ||:.:........|..|....:::
Zfish   417 INKENEETIENTTETAKVVKEKPLQLSTLFNGLLSPKKEVLEEKDEPGQPRSTSKRGLFTDQSNK 481

  Fly   125 FEKPIDYVE----YLQNGEHSTHKVYQCVESLRVALTSNPISWIKEFGVAGIGTI--EKLLARSK 183
            .|...|::|    :|..||....:     ||    ::|.|:|.:.:..|....|.  |.::.:|:
Zfish   482 KEVKADFLEQLTQFLSKGEGKRKQ-----ES----ISSPPMSPVSQETVENPETTVEEPVIPQSE 537

  Fly   184 NNASYEKIE--------FEAIRCLKAIMNNTWGLNVV---LNPDQHSVVLLLAQSLDPRKPQTMC 237
            ........|        |..::..|...:|...|::|   :|.|:
Zfish   538 ETNKSSNAETALGALKAFFTVKSAKKDSSNRKDLDIVKKKINRDK-------------------- 582

  Fly   238 EALKLLASFCIVYERNGYEKVLRAITTIAATSFKASERFRPIVDALFASDQQDPKRDLACHSLIF 302
               ::|.:|   ::||..:          :...|.:...:|.|     ||:..|||
Zfish   583 ---EVLRAF---FDRNSSK----------SPEIKDTTDCKPEV-----SDEHTPKR--------- 617

  Fly   303 INTLTNTPTDLN------------------FRLHLRC--EIMRMGLYDRLDEFTKIVEASNNENL 347
            :.|:...|...:                  .:|...|  |:.::....||:.|.  ::..|.:||
Zfish   618 LQTVWPPPKPKDEEEKIGLKYTEAEHQAALLQLKRECNEEVEKLQTDFRLELFR--IQEKNEQNL 680

  Fly   348 QQHFKIFNEIREDDFEEFVQRFDNVTFNMDDATDCFDV----LKNLVTDTTSEPYFLSILQHLLY 408
            .:.......::.:..:...:...:|..:.:|     |:    ::::...|..|....|
Zfish   681 SRLSATIASLQRERDKVHHREHQHVAVSTED-----DIKARAVRSVCIQTDRETSINS------- 733

  Fly   409 IRDDFYFRPAYYQLIEECISQIVFHKGYCDPNFENRNFNIDTSLLLDDIVEKAKAKESKRSEEYE 473
                           ||....   |....||.|:|.:.|..|
Zfish   734 ---------------EEAKET---HSNSLDPLFKNGDLNNST----------------------- 757

  Fly   474 KKIEQLESAKQEAEAKAAHLEEKVKL-MEANGVAAPSPNKLP---------------KVNIPMPP 522
               :.|...::.....:||.....:| :|::.:..|:|..||               .||:|.||
Zfish   758 ---KNLTGKQKTVPPPSAHPPPSPQLQLESSKITPPTPPPLPGPCTPNIPLAQPPNKHVNVPPPP 819

  Fly   523 PPP-----GGGGAPPPPPPPMPGRAGGGPPPP-PPPPMPGRAGGPPPPP-PPPGMGG----PPPP 576
            |||     .|.|.|||||||.|....|.|||| |||||.|....||||| |||.|.|    ||||
Zfish   820 PPPPPPPMTGSGLPPPPPPPPPMTGSGLPPPPLPPPPMTGSDLPPPPPPLPPPNMTGSGLPPPPP 884

  Fly   577 PMPGMMRPGGGPPPPPMMMGPMVPVLPHGL---------KPKKKWDVKNP-------MKRANWKA 625
            ||.|    .|.|||||..|...:|..|.|.         .|:|      |       ||...|..
Zfish   885 PMTG----SGFPPPPPPPMLHSIPPPPPGFGFFSKTADTSPRK------PSVEPVCAMKPLYWTR 939

  Fly   626 IVPAKMSDKAFWVKCQEDKLAQDDFLAELAVKFSSKPVKKEQKDAVDKPTTLTKKNVDLRVLDSK 690
            |...:..:...|...:|.::...:..|||..|.:|...:|...||.:|.|...|.   :::||.|
Zfish   940 IQIQECRNDVLWSSLKEPEIINTNEFAELFAKATSPTKRKPLSDAYEKKTKARKV---IKLLDGK 1001

  Fly   691 TAQNLAIMLGGSLKHLSYEQIKICLLRCDTDILSSNILQQLIQYLPPPEHLKRL---------QE 746
            .:|.:.|::  |..||..:.|:..:|..|..::..:.::.|.:....||.|:::         ::
Zfish  1002 RSQAVGILI--SSLHLEMKDIQQAVLTLDDTVVDLDAIEALYENRAQPEELEKIKKHYETSDEEQ 1064

  Fly   747 IKAKGEPLPPIEQFAATIGEIKRLSPRLHNLNFKLTYADMVQDI--KPDIVAGTAACEEIRNSKK 809
            :|...:|    |||...:.:|...|.|:|...|:..:.|.|..|  |.:|:  ...|:.:.....
Zfish  1065 VKLLDKP----EQFLYELSQIPEFSSRVHCFIFQTKFTDAVASIQRKTEII--HHVCKFLLEKDS 1123

  Fly   810 FSKILELILLLGNYMNSGSKNEA-AFGFEISYLTKLSNTKDADNKQTLLHYLADLVEKKFPDALN 873
            ..:::.|:|.||||||.||:... |.||.:..|.||.:.|..:|..:||.|:           ::
Zfish  1124 TREVMGLVLALGNYMNGGSRARGQADGFGLEILPKLKDVKSRENHISLLDYI-----------VS 1177

  Fly   874 FYDDLSHVNK-------------------ASRVNMDAIQKAMRQMNSAVKNLETDLQNNKVPQCD 919
            :|  |.|::|                   :|:|..|.:.|.:|::...:...|.|:    :..|.
Zfish  1178 YY--LHHLDKNAGTEKSIFPLPEPQDVFLSSQVKFDDLSKDLRKLGRDLTVCEKDV----LTVCT 1236

  Fly   920 DDK------FSEVMGKFAEECRQQVDVLGKMQLQMEKLYKDLSEYYAFDPSKYTMEEFFADIKTF 978
            :..      |.|.|..|.....:::..:....:...|.:.||.||:...|.  :.|:..|....|
Zfish  1237 NSSQEHIHPFQEKMDFFIASAPKELITMEHQVVSARKSFSDLVEYFGLKPR--SGEQEVAPGNVF 1299

  Fly   979 KDAFQAAHNDNVRVREE--LEKKRRLQEAREQSAREQ--QERQQRKKA 1022
            ...|:..::..:|.:.|  :..|:||:|| :||.|..  :::.:.::|
Zfish  1300 TLWFEFCNDFKIRWKRENKIISKQRLKEA-QQSVRNMTAEKKIETRRA 1346

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dia	NP_001246113.1	Drf_GBD	66..248	CDD:283920	38/212 (18%)
		Drf_FH3	253..453	CDD:283917	35/223 (16%)
		FH2	608..983	CDD:280362	97/418 (23%)
fmn1	XP_689569.3	FH2	922..1310	CDD:280362	97/423 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910