Protein Alignment dia and daam1a

DIOPT Version :9

• Sequence 1: NP_001246113.1
• Gene: dia / 35340
• FlyBaseID: FBgn0011202
• Length: 1098
• Species: Drosophila melanogaster
• Sequence 2: XP_017207260.1
• Gene: daam1a / 557451
• ZFINID: ZDB-GENE-030911-6
• Length: 1069
• Species: Danio rerio
• Alignment Length: 1122
• Identity: 324/1122 - (28%)
• Similarity: 555/1122 - (49%)
• Gaps: 167/1122 - (14%)

  Fly    41 TLAHGGRPVSADNYVVPGVEDFEQYIQQLSVAELDAKFLEIIEDMNIPKDKREPLLAKSKEERQK 105
            :|.||      .|:.   ::..|..:......||||.|.|:::::::.:..|..:.|...|::
Zfish    30 SLRHG------SNFT---LQTMEPTLPMPPTEELDAMFTELVDELDLTEKHRAAMFALPAEKK-- 83

  Fly   106 MIMWHL----KGKNSLERSANSRFEKPIDYVEYL----------QNGEHSTHKVYQCVESLRVAL 156
               |.:    |.:....:.|.|..|..||.:..:          :..|...:|.   :|||:.||
Zfish    84 ---WQIYCSKKKEQEENKGATSWPEFYIDQINSMAARKSLLALEKEDEEERNKT---IESLKTAL 142

  Fly   157 TSNPISWIKEF-GVAGIGTIEKLLARSKNNASYEKIEFEAIRCLKAIMNNTWGLNVVLNPDQHS- 219
            .:.|:.::..| ...|:..|...|.......:..:|....|.|:||:|||:.|...||:   ||
Zfish   143 RTQPMRFVTRFIDQDGLTCILNFLKTMDYETTESQIHTSLIGCIKALMNNSQGRAHVLS---HSE 204

  Fly   220 VVLLLAQSLDPRKPQTMCEALKLLASFCIVYERNGYEKVLRAITTIAATSFKASERFRPIVDALF 284
            .:.::||||.....:|....|:::.:.|:|  ..|::|:|.|:......:.:.: ||:.:::.|.
Zfish   205 SINIIAQSLATENIKTKVAVLEIMGAVCLV--PGGHKKILEAMLHYQKFACERT-RFQTLLNDLD 266

  Fly   285 AS-----DQQDPKRDLACHSLIFINTLTNT---PTDLNFRLHLRCEIMRMGLYDRLDEFTKIVEA 341
            .|     |:.:.|..:    :.|||.:.:.   .|.|.||:|||.|.:.:|:...:|:    :.:
Zfish   267 RSTGRYRDEVNLKTAI----MSFINAVLSQGAGETSLEFRIHLRYEFLMLGIQPVIDK----LRS 323

  Fly   342 SNNENLQQHFKIFNEIREDDFEEFVQRFDNVTFNMDDATDCFDVLKNLVTDTTSEPYFLSILQHL 406
            ..|..|.:|...|..:|.:|.....:||:||..:...||..|::::..:..|.:.|:|:|:|||.
Zfish   324 HENSTLDRHLDFFEMLRNEDELALAKRFENVHVDTKSATQMFELIRKRINHTDAFPHFISVLQHC 388

  Fly   407 LYIRDDFYFRPA----YYQLIEECISQIVFH--KGYCDP------NFENRNFNIDTSLLLDDIVE 459
            |::.   |.:..    |:.|::..:.||:..  || .||      ||:.:  |:...|:.::.|:
Zfish   389 LHMP---YKKTGNTVQYWVLLDRIVQQIILQNDKG-LDPDVAPLENFDVK--NVVRMLVNENEVK 447

  Fly   460 KAKAKESKRSEEYEKKIEQLESAKQEAEAKAAHLEE--------KVKLMEANGVAAPSPNKLPK- 515
            :.|.:..|..:|:.:..::||..::|.:|||...||        |.||.:.:     |.:||.|
Zfish   448 QWKEQAEKMRKEHNELQQKLEKKERECDAKAQEKEEMMQTLNKMKEKLEKES-----SEHKLVKQ 507

  Fly   516 ---------------VNIPMPPP-PPGGGGAPPPPPPPMPGRAGGGPPPPPPPPMPGRAGGPPPP 564
                           .|||..|| .|.|.|.||||||  ||:||   .||||||    .|.||||
Zfish   508 QVADLSARLHEMSNRTNIPGGPPLAPLGPGLPPPPPP--PGQAG---LPPPPPP----GGAPPPP 563

  Fly   565 PPPPGMGGPPPPPMPGMMRPG-GGPPPPPMMMGPMVPVLPHGLKPKKKWDVKNPMKRANWKAIVP 628
            ||||  ||||||  ||::  | |.||||..::|..       ||.|......||:|..||..:..
Zfish   564 PPPP--GGPPPP--PGLL--GFGAPPPPGGLLGST-------LKKKNIPQPSNPLKSFNWTKLSE 615

  Fly   629 AKMSDKAFWVKCQEDKLAQDDFLAELAVKFSSKPVKKE-------QKDAVDKPTTLTKKNVDLRV 686
            .|: :...|:...:.::.:...|.::...||:...:::       ||::.| .|..:||..:|.|
Zfish   616 NKL-EGTVWLDLDDVRVFKQLDLEDIEKTFSAYQRQQDFLFNNFRQKESED-DTVTSKKVKELSV 678

  Fly   687 LDSKTAQNLAIMLGGSLKHLSYEQIKICLLRCD-TDILSSNILQQLIQYLPPPEHLKRLQEIKAK 750
            :|.:.|||..|:| ..|| ||.|:||..:|..| .:.|..::|:||::::|....:..|:|.|.:
Zfish   679 IDGRRAQNCNILL-SKLK-LSNEEIKRAILTMDEQEDLPKDMLEQLLKFVPEKSDVDLLEEHKHE 741

  Fly   751 GEPLPPIEQFAATIGEIKRLSPRLHNLNFKLTYADMVQDIKPDIVAGTAACEEIRNSKKFSKILE 815
            .|.:...::|...:..|.....||.:|.||..:|:.:.:|||.:.|.:.|.:|:..||...::||
Zfish   742 LERMAKADRFLYEMSRINHYQQRLQSLYFKKKFAERIAEIKPKVEALSKASKEVLQSKNLRQLLE 806

  Fly   816 LILLLGNYMNSGSKNEAAFGFEISYLTKLSNTKDA-DNKQTLLHYLADLVEKKFPDALNFYDDLS 879
            ::|..|||||.|.:.. |:||::|.|.|:::||.: |...||||||..::|:|:|.....::||.
Zfish   807 IVLAFGNYMNKGQRGN-AYGFKVSSLNKIADTKSSIDKNVTLLHYLITVLEQKYPKVSLIHEDLQ 870

  Fly   880 HVNKASRVNMDAIQKAMRQMNSAVKNLETDLQNNKV-PQCDDDKFSEVMGKFAEECRQQVDVLGK 943
            :|..|::|||..::|.:..:.|.:|::||:|:..:. ||...|||..|:.:|       :.|.|.
Zfish   871 NVPVAAKVNMTELEKDINNLRSGLKSVETELEYQRTQPQTYGDKFVSVVSQF-------ITVAGF 928

  Fly   944 MQLQMEKLYKDLS-------EYYAFDPSKYTMEEFFADIKTFKDAFQAA--HNDNVRVREELEKK 999
            ....:|...:|..       :::..|.::...:|||.....|...|..|  .|:|:|.|:|.|::
Zfish   929 SFSDIEDSLQDAKDSFGKAVQHFGEDATRMQPDEFFGIFDQFLQGFSEAKQDNENMRRRKEEEER 993

  Fly  1000 RRLQEA--REQSAREQQERQQRKKAVVDMDAPQTQEGVMDSLLEALQTGSAFGQRNRQARRQRPA 1062
            |...||  :||..||::.|:.::..        .::|..|.|:.||::|..|.:...:.:..|..
Zfish   994 RARMEAQLKEQRERERKSRKAKENC--------EEDGEFDDLVSALRSGEVFDKDMSKMKHNRKR 1050

  Fly  1063 GAERRAQLSRSRSRTRV 1079
            ..:..|:.||.|..|::
Zfish  1051 PVKSSAESSRERPVTKL 1067

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
dia	NP_001246113.1	Drf_GBD	66..248	CDD:283920	47/197 (24%)
		Drf_FH3	253..453	CDD:283917	56/219 (26%)
		FH2	608..983	CDD:280362	115/391 (29%)
daam1a	XP_017207260.1	Drf_GBD	46..233	CDD:283920	47/197 (24%)
		Drf_FH3	236..440	CDD:283917	56/218 (26%)
		DUF342	<447..525	CDD:302792	18/82 (22%)
		FH2	595..975	CDD:280362	115/391 (29%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1204639at2759
OrthoFinder	1	1.000	-	-		FOG0000085
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.920