Protein Alignment dia and fmnl1a

DIOPT Version :10

• Sequence 1: NP_001246113.1
• Gene: dia / 35340
• FlyBaseID: FBgn0011202
• Length: 1098
• Species: Drosophila melanogaster
• Sequence 2: XP_685133.5
• Gene: fmnl1a / 557062
• ZFINID: ZDB-GENE-120215-83
• Length: 1085
• Species: Danio rerio
• Alignment Length: 1156
• Identity: 299/1156 - (25%)
• Similarity: 494/1156 - (42%)
• Gaps: 282/1156 - (24%)

  Fly    73 ELDAKFLEIIEDMNIPKDKREPLLAKSKEERQKMI---------------MWHLKGKNSLERSAN 122
            ||:.:|..::..||:|.||.:.|.....|::.:::               :..:|.....:....
Zfish    46 ELEERFNVVLSTMNLPPDKMKLLSQYDNEKKWELVCDQERFQVKNPPSAYLTKIKSFYQDQGGVT 110

  Fly   123 SRFEKPIDYVEYLQNGEHSTHKVYQCVESLRVALTSNPISWIKEF---GVAGIGTIEKLLARSKN 184
            .||:|.:         :.||    |.:..|.::|.:|.|.|.:||   ...|:..:...|:.|::
Zfish   111 RRFKKRV---------QEST----QVLRELEISLRTNHIGWAQEFLNEENQGLDVLVDYLSYSQS 162

  Fly   185 NASYEKIEFE------------------------------------------------------- 194
            :..:|....|
Zfish   163 DVPFEVESVENGGSISDNRRMSERSVEDLAKNVNHSAPHTMTRAARALTVRITSLAHSRKTLRIA 227

  Fly   195 -----------AIRCLKAIMNNTWGLNVVLNPDQHSVVLLLAQSLDPRKPQTMCEALKLLASFCI 248
                       .|.||:||||...|.|:|:...:  .|..:..||:.:.|:|....|:|||:.|:
Zfish   228 RLATQRDDVHLCIMCLRAIMNYQSGFNLVMTHPR--CVNEITLSLNNKNPRTKALVLELLAAVCL 290

  Fly   249 VYERNGYEKVLRAITTIAATSFKASERFRPIVDALFASDQQDPKRDLACHSLIFINTLTNTPTDL 313
            |  |.|::.::.|.......|.: ..||..::: .|..|..:....:||  :.|||.:.::..::
Zfish   291 V--RGGHDIIISAFDNFKDASGE-KNRFEKLME-YFMHDDSNVDFMVAC--MQFINIVVHSVENM 349

  Fly   314 NFRLHLRCEIMRMGLYDRLDEFTKIVEASNNENLQQHFKIFNEIREDDFEEFVQRFDNVTFN--- 375
            |||:||:.:..::|    ||::.:.::...:|.||...:.:              .||| |:
Zfish   350 NFRVHLQYQFSQLG----LDQYLESLKDMESEKLQVQIQAY--------------LDNV-FDVGA 395

  Fly   376 -MDDATDCFDVLKNLVTDTTSEPYFLSILQHLLYIRDDFYFRPAYYQLIEECISQIVFHKGYCDP 439
             ::||.:..|:: :||.|                              ::|..:|:......|:.
Zfish   396 LLEDAENKGDIV-DLVAD------------------------------LQENNAQLTARLQECEN 429

  Fly   440 NFENRNFNIDTSLLLDDIVEKAKAKESKR----------SEEYEKKIEQLESAKQEAEA------ 488
            ...::...::.. ||....|.|..|||.|          ..|.|::|::....:||.::
Zfish   430 GALDKIAELEQQ-LLQATKESALLKESLRESCTQVSTLQQREREREIQREREREQERQSQPSQVD 493

  Fly   489 ------KAAHLEEKVKLMEANGVAAPS------------PNKLPK-----VNIP----MPPPPPG 526
                  |.:.||:|:|.::..|:....            |..|.|     |.:|    ..||.|.
Zfish   494 REKGSEKESKLEKKLKELQEKGLLRLERTVSGSLDIDVIPVTLEKIVTQTVTVPDSASQAPPSPA 558

  Fly   527 GGGAPPPPPPPMPGRAGGGPPPPPPPPMPGRAGG---PPPPPPPPGMGGPPPPPMPGMMRPGGGP 588
            ....|||||||:||  ...||||||||.|..:||   ||||||||| |||||||.|    ||.||
Zfish   559 AAPPPPPPPPPLPG--AEAPPPPPPPPPPSGSGGAPPPPPPPPPPG-GGPPPPPPP----PGSGP 616

  Fly   589 PPPPMMMGPMVPVLPHGLKPKKKWDVKNPMKRANWKAIVPAKMSDKAFWVKCQE---DKLAQDDF 650
            ||||  ..|..|....|.|.:|....|..|...||:|:.|.::|...|.....|   :.|..|.|
Zfish   617 PPPP--GAPPAPGAETGPKARKTIQTKFRMPLLNWQALKPNQVSGTVFSELNDEQVLEALNMDLF 679

  Fly   651 LAELAVKFSSKPV---KKEQKDAVDKPTTLTKKNVDLRVLDSKTAQNLAIML--GGSLKHLSYEQ 710
            ..:...|....|.   |.:.|.|...||.::       :|::..|:||||.|  ||      ...
Zfish   680 AEQFKTKAQGPPADLSKLKVKVAEKAPTKVS-------LLEANKAKNLAITLRKGG------MNP 731

  Fly   711 IKIC-LLRCDTDILSSNILQQLIQYLPPPEHLKRLQEIKAKGEPLPPI---EQFAATIGEIKRLS 771
            .||| .:......||.:.|:.|.:::|....:|.||..:.:|.||..:   ::|.:..|:|.|||
Zfish   732 DKICTAIESYDQSLSLDFLELLERFIPSEYEMKLLQNYEKEGRPLEDLSEEDRFISRFGKIPRLS 796

  Fly   772 PRLHNLNFKLTYADMVQDIKPDIVAGTAACEEIRNSKKFSKILELILLLGNYMNSGSKNEAAFGF 836
            .|::.|.|...:.:.::.::|.:.|..||...:::|.|..|:||:||..|||||| ||..||:||
Zfish   797 QRINTLTFMGNFPESIKRLQPQLDAIIAASVSLKSSSKLKKMLEIILAFGNYMNS-SKRGAAYGF 860

  Fly   837 EISYLTKLSNTKDADNKQTLLHYLADLVEKKFPDALNFYDDLSHVNKASRVNMDAIQKAMRQMNS 901
            .:..|..|.:||..|..|||||::|::|.:|:|:..:|:::|..|:||:.|::|.:.:.:|.:..
Zfish   861 RLQSLDLLLDTKSTDRTQTLLHFIANMVHEKYPELTSFHNELRFVDKAALVSLDGVLQDVRSLER 925

  Fly   902 AVKNLETD-LQNNKVPQCDDDKFSEVMGKFAEECRQQVDVLGKMQLQMEKLYKDLSEYYAFDPSK 965
            .::..:.: :..:.:|         .:.:|.:.....:|.|.|.....::.|..:.|||..:|..
Zfish   926 GMEGTKKEFMVQDDIP---------ALKEFVKANSDVLDSLVKDGKTAQEAYAAVVEYYGENPKT 981

  Fly   966 YTMEEFFADIKTFKDAFQAAHNDNVRVREELEKKRRLQEAREQ---SAREQQERQQRKKAVVDMD 1027
            .....||.....|..|::.|..||.      :||::...|.||   |.::::...|:...:..||
Zfish   982 TQPSMFFPIFARFIKAYKQAEQDNE------QKKKQEMAAEEQATPSPKKKEGTPQKGPMMPKMD 1040

  Fly  1028 ----------APQTQEGVMDSLLEALQTGSAFGQRNRQARRQRPAGAERRA 1068
                      .||..:|.:|.::..|        ||...||    |..|||
Zfish  1041 LIAELKKRQVKPQVTDGAIDDIITDL--------RNSPYRR----GDGRRA 1079

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
dia	NP_001246113.1	Drf_GBD	66..248	CDD:461886	48/258 (19%)
		Drf_FH3	253..453	CDD:461885	36/203 (18%)
		FH2	608..983	CDD:396655	111/387 (29%)
fmnl1a	XP_685133.5	None