Protein Alignment dia and Fmn2

DIOPT Version :10

• Sequence 1: NP_001246113.1
• Gene: dia / 35340
• FlyBaseID: FBgn0011202
• Length: 1098
• Species: Drosophila melanogaster
• Sequence 2: NP_062318.2
• Gene: Fmn2 / 54418
• MGIID: 1859252
• Length: 1578
• Species: Mus musculus
• Alignment Length: 633
• Identity: 176/633 - (27%)
• Similarity: 271/633 - (42%)
• Gaps: 136/633 - (21%)

  Fly   504 GVAAPSPNKLPKVNIPMPPPPPGGGGAPP--------PPPPPMPGRAGGGPPP-------PPPPP 553
            ||..|.|..||.|.||.|||.||.|..||        |||||:|| .|..|||       |||||
Mouse   973 GVGIPPPPPLPGVGIPPPPPLPGVGIPPPPPLPGVGIPPPPPLPG-VGIPPPPPLPGVGIPPPPP 1036

  Fly   554 MPGRAGGPPPP-------PPPPGMGG---PPPPPMPGM-------MRPGGGPPPPPMMMGP---- 597
            :|| .|.||||       ||||.:.|   |||||:|||       ..||.|.||||::.|.
Mouse  1037 LPG-VGIPPPPPLPGSGIPPPPALPGVAIPPPPPLPGMGVPPPAPPPPGAGIPPPPLLPGSGPPH 1100

  Fly   598 ------------------MVPVLPHGL----------KPKKKWDVKNPMKRANWKAIVPAKMSDK 634
                              :.|.||.||          ..|:..:...|||...|..|......|.
Mouse  1101 SSQVGSSTLPAAPQGCGFLFPPLPTGLFGLGMNQDRVARKQLIEPCRPMKPLYWTRIQLHSKRDS 1165

  Fly   635 A---FWVKCQEDKLAQDDFLAELAVKFSSKPVKKEQKDAVDKPTTLTKKNVDLRVLDSKTAQNLA 696
            :   .|.|.:|..:...:| .||..|.:.|..||...|.:.|    ||....:::|.:|.:|.:.
Mouse  1166 SPSLIWEKIEEPSIDCHEF-EELFSKTAVKERKKPISDTISK----TKAKQVVKLLSNKRSQAVG 1225

  Fly   697 IMLGGSLKHLSYEQIKICLLRCDTDILSSNILQQLIQYLPPPEHLKRLQ------EIKAKGEPLP 755
            |::  |..||..:.|:..::..|..::....||.|.:.....:.|::::      :.|...:.|.
Mouse  1226 ILM--SSLHLDMKDIQHAVVNLDNSVVDLETLQALYENRAQSDELEKIEKHSRSSKDKENAKSLD 1288

  Fly   756 PIEQFAATIGEIKRLSPRLHNLNFKLTYADMVQDIKPDIVAGTAACEEIRNSKKFSKILELILLL 820
            ..|||...:..|...|.|:..:.|:.|:::.:..|:..:......||.::|.....::|.|:|..
Mouse  1289 KPEQFLYELSLIPNFSERVFCILFQSTFSESICSIRRKLELLQKLCETLKNGPGVMQVLGLVLAF 1353

  Fly   821 GNYMNSGSKNEA-AFGFEISYLTKLSNTKDADNKQTLLHYLADLVEKKFPDALNFYDDL------ 878
            |||||:|:|... |.||.:..|.||.:.|.:||.::||.|:.....:      ||.:|.
Mouse  1354 GNYMNAGNKTRGQADGFGLDILPKLKDVKSSDNSRSLLSYIVSYYLR------NFDEDAGKEQCV 1412

  Fly   879 ------SHVNKASRVNMDAIQKAMRQMNSAVKNLETDLQNNKVPQCDD----DKFSEVMGKFAEE 933
                  ..:.:||::..:..||.:|::...:|..|.:.  .||.|...    ..|.|.|.:|..:
Mouse  1413 FPLAEPQELFQASQMKFEDFQKDLRKLKKDLKACEAEA--GKVYQVSSAEHMQPFKENMEQFISQ 1475

  Fly   934 CRQQVDVLGKMQLQMEKLYKDLSEYYAFDPSKYTME-----------EFFADIKTFKDAFQAAHN 987
            .:...:.......:..|.:.:.:.||...|.....|           ||.:|   ||||::   .
Mouse  1476 AKIDQESQEAALTETHKCFLETTAYYFMKPKLGEKEVSPNVFFSVWHEFSSD---FKDAWK---K 1534

  Fly   988 DNVRVREELEKKRRLQEAREQSAREQQERQQRKKAVVDMDAPQTQEGV 1035
            :|..:.:|     |::||.|..      ||::.|::..: .|:...|:
Mouse  1535 ENKLILQE-----RVKEAEEVC------RQKKGKSLYKV-KPRHDSGI 1570

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
dia	NP_001246113.1	Drf_GBD	66..248	CDD:461886
		Drf_FH3	253..453	CDD:461885
		FH2	608..983	CDD:396655	99/411 (24%)
Fmn2	NP_062318.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..73
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	208..230
		PHA03307	216..>535	CDD:223039
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	244..383
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	401..458
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	587..634
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	714..765
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	786..836
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	880..944
		12 X 11 AA tandem repeats of [MV]-G-I-P-P-P-P-P-L-P-G	919..1039		33/66 (50%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1037..1108		28/71 (39%)
		FH2	1139..1529	CDD:396655	95/407 (23%)
		Important for interaction with SPIRE1. /evidence=ECO:0000269|PubMed:21705804	1571..1578		176/633 (28%)