DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dia and Diaph2

DIOPT Version :9

Sequence 1:	NP_001246113.1	Gene:	dia / 35340	FlyBaseID:	FBgn0011202	Length:	1098	Species:	Drosophila melanogaster
Sequence 2:	XP_006528644.1	Gene:	Diaph2 / 54004	MGIID:	1858500	Length:	1109	Species:	Mus musculus

Alignment Length:	1050	Identity:	425/1050 - (40%)
Similarity:	636/1050 - (60%)	Gaps:	75/1050 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    69 LSVAELDAKFLEIIEDMNIPKDKREPLLAKSKEERQKMIMWHLK-------GKNSLERSANSRFE 126
            ||..|:...|.:::||||:.::|:.||..|....:::|::.::.       |...|....||:.|
Mouse   104 LSEKEVLDLFEKMMEDMNLNEEKKAPLRKKDFSIKREMVVQYISATSKSIVGSKVLGGLKNSKHE 168

  Fly   127 KPI---DYVEYLQNGEHSTHKVYQCVESLRVALTSNPISWIKEFGVAGIG----TIEKLLARSKN 184
            ..:   :||..|::| .|..|:..|:|||||:|||:|:||:..||..|:|    .:||||.:.:.
Mouse   169 FTLSSQEYVHELRSG-ISDEKLLNCLESLRVSLTSHPVSWVNNFGYEGLGVLLDVLEKLLDKKQQ 232

  Fly   185 NASYEKIEFEAIRCLKAIMNNTWGLNVVLNPDQHSVVLLLAQSLDPRKPQTMCEALKLLASFCIV 249
            ....:|.:::.|:||||.|||.:||..:|. |:.| :||||:::||::...|.|.:|:|::.|||
Mouse   233 ENIDKKNQYKVIQCLKAFMNNKFGLQRILG-DERS-LLLLARAIDPKQQNMMTEIVKILSAICIV 295

  Fly   250 YERNGYEKVLRAITTIAATSFKASERFRPIVDALFASDQQDPKRDLACHSLIFINTLTNTPTDLN 314
            .|.|..:|:|..||  ||......|||.|||:.|  .:.:.....:||  :.|||.|..:|.||:
Mouse   296 GEENILDKLLGGIT--AAAELNNRERFSPIVEGL--ENNEALHLQVAC--MQFINALVTSPYDLD 354

  Fly   315 FRLHLRCEIMRMGLYDRLDEFTKIVEASNNENLQQHFKIFNEIREDDFEEFVQRFDNVTFNMDDA 379
            ||:|||.|.:|.||...|....:|    .||.|....::|.|.:|||..|...|.:::...|||.
Mouse   355 FRIHLRNEFLRCGLKAMLPTLKEI----ENEGLDIQLRVFEENKEDDLSELSHRLNDIRAEMDDI 415

  Fly   380 TDCFDVLKNLVTDTTSEPYFLSILQHLLYIRDDFYFRPAYYQLIEECISQIVFHKGYCDPNFENR 444
            .:.:.:|.|::.||.:|||.||||||.|.||:|:|.||.||::||||:||||.|....||:|:.|
Mouse   416 NEVYHLLYNMLKDTAAEPYLLSILQHFLLIRNDYYIRPQYYKIIEECVSQIVLHCSGMDPDFKYR 480

  Fly   445 -NFNIDTSLLLDDIVEKAKAKES-KRSEEYEKKIEQLESAKQEAEAKAAHLEEKVKLMEA----- 502
             ..:.|.:.|||..|.|||.:|: :::.|:.||.::..:|:|||:|:....:||:|.:|.
Mouse   481 QRIDFDFTHLLDACVNKAKVEENEQKAMEFSKKFDEEFTARQEAQAELQKRDEKIKELETEIQQL 545

  Fly   503 NGVAAPSPNKLPKVNIPMPPPPPGGGGAPPPPPPPMPGRAGGGPPPPPPPPMPGRAGGPPPPPPP 567
            .|...||.       ||.|||||...||.|.||||        ||||||||:||..  ||||||.
Mouse   546 RGQGVPSA-------IPGPPPPPPLPGAGPCPPPP--------PPPPPPPPLPGVV--PPPPPPL 593

  Fly   568 PGMGG---PPPPPMPGMMRPGGGPPPP----PMMMGPMVPVLPHGLKPKKKWDVKNPMKRANWKA 625
            |||.|   |||||:.|:..|   ||||    |::.||:  .||:|:|.||.:....||||.||..
Mouse   594 PGMPGIPPPPPPPLSGVPPP---PPPPGGVFPLLSGPI--ELPYGMKQKKLYKPDIPMKRINWSK 653

  Fly   626 IVPAKMSDKAFWVKCQEDKLAQDDFLAELAVKFSSKPVKKEQKDAVDKPTT--LTKKNVDLRVLD 688
            |.|.::|:...|:|.:|:|....|..|:||:.|.|:...:...:|.::..:  ..||..:||:||
Mouse   654 IEPKELSENCVWLKLKEEKYENADLFAKLALTFPSQMKGQRNTEAAEENRSGPPKKKVKELRILD 718

  Fly   689 SKTAQNLAIMLGGSLKHLSYEQIKICLLRCDTDILSSNILQQLIQYLPPPEHLKRLQEIKAKGEP 753
            :||||||:|.||.  ..:.||:||..:|..:.::||..::|.|::|||....|:.|.::|::.:.
Mouse   719 TKTAQNLSIFLGS--YRMPYEEIKNIILEVNEEMLSEALIQNLVKYLPDQNALRELAQLKSEYDD 781

  Fly   754 LPPIEQFAATIGEIKRLSPRLHNLNFKLTYADMVQDIKPDIVAGTAACEEIRNSKKFSKILELIL 818
            |...|||...:..:|.|.|||.::.||||:.:.|.:|||.|:|.|.||||::.|:.|.::|||||
Mouse   782 LCEPEQFGVVMSTVKMLRPRLTSILFKLTFEEHVNNIKPSIIAVTLACEELKKSESFKRLLELIL 846

  Fly   819 LLGNYMNSGSKNEAAFGFEISYLTKLSNTKDADNKQTLLHYLADLVEKKFPDALNFYDDLSHVNK 883
            |:||||||||:|..:.||:|::|.|:.:||.||.|.||||:||::.::|:.|.|.|.|:|.||..
Mouse   847 LVGNYMNSGSRNAQSLGFKINFLCKIKDTKSADQKSTLLHFLAEICDEKYRDILKFPDELEHVES 911

  Fly   884 ASRVNMDAIQKAMRQMNSAVKNLETDLQNNKVPQCDDDKFSEVMGKFAEECRQQVDVLGKMQLQM 948
            |.:|:...::..:..|..::.:||.:::|....:...|||.|.|..|.:..|:|.|.|..|...|
Mouse   912 AGKVSAQILKSNLVAMEQSILHLEKNIKNFPPAESHHDKFVEKMMSFTQNAREQYDKLSTMHSNM 976

  Fly   949 EKLYKDLSEYYAFDPSKYTMEEFFADIKTFKDAFQAAHNDNVRVREELEKKRRLQEAREQSAREQ 1013
            .|||:.|.||:.|||:...|||||.|:.||:..|..|..:|.:.:|..||.||.:.|:|::.:|:
Mouse   977 LKLYESLGEYFIFDPNTVNMEEFFGDLNTFRTLFLEALKENHKRKEMEEKSRRAKLAKEKAEQEK 1041

  Fly  1014 QERQQRKKAVVDMDAPQTQEGVMDSLLEALQTGSAFGQRNRQARRQRPAGAE-RRAQLSRSRSRT 1077
            .|||::||.::|::....:.||||:||||||:|:||    |..|::.|...: ||..|.|||||
Mouse  1042 LERQKKKKQLIDINKEGDETGVMDNLLEALQSGAAF----RDRRKRIPRNPDNRRPPLERSRSR- 1101

  Fly  1078 RVTNGQLMTR 1087
              .||.:.::
Mouse  1102 --HNGAMSSK 1109

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dia	NP_001246113.1	Drf_GBD	66..248	CDD:283920	68/192 (35%)
		Drf_FH3	253..453	CDD:283917	83/200 (42%)
		FH2	608..983	CDD:280362	152/376 (40%)
Diaph2	XP_006528644.1	Drf_GBD	104..294	CDD:368864	68/192 (35%)
		Drf_FH3	302..490	CDD:368862	82/197 (42%)
		FH2	637..1072	CDD:214697	177/436 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167846930
Domainoid	1	1.000	323	1.000	Domainoid score	I1204
eggNOG	1	0.900	-	-		E1_KOG1924
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	732	1.000	Inparanoid score	I608
Isobase	1	0.950	-	0	Normalized mean entropy	S4054
OMA	1	1.010	-	-		QHG52328
OrthoDB	1	1.010	-	-		D1204639at2759
OrthoFinder	1	1.000	-	-		FOG0000085
OrthoInspector	1	1.000	-	-		otm44251
orthoMCL	1	0.900	-	-		OOG6_101727
Panther	1	1.100	-	-	LDO	PTHR45691
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3069
SonicParanoid	1	1.000	-	-		X420
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	16	15.750