Protein Alignment dia and fhod1

DIOPT Version :10

• Sequence 1: NP_001246113.1
• Gene: dia / 35340
• FlyBaseID: FBgn0011202
• Length: 1098
• Species: Drosophila melanogaster
• Sequence 2: XP_021333585.2
• Gene: fhod1 / 503946
• ZFINID: ZDB-GENE-110623-4
• Length: 1441
• Species: Danio rerio
• Alignment Length: 821
• Identity: 198/821 - (24%)
• Similarity: 324/821 - (39%)
• Gaps: 229/821 - (27%)

  Fly   458 VEKAKAKESKRSEEYEKKIEQLESAKQEAEAKAAHLEEKVKLMEAN---GVAAPSPNK-LPK-VN 517
            :.:.::..|:.:|:..::.| |||....|:|..|.|.|:.||.:..   .:.|.:.:: |.| :.
Zfish   666 LSRLQSSSSQPTEDPSRRAE-LESLGGTADAARARLAEEQKLKKLRPQYSIEAETHSQSLEKTLM 729

  Fly   518 IPM------------PPPPP---------------------------GGGGAPPPPPPPMPGRAG 543
            .|:            |...|                           |.....||||||:|| .|
Zfish   730 TPLSRGSQDAWDKLQPSSRPLRIKDLDFSDLMEEEDIDVLDIDTFDTGLSNVIPPPPPPVPG-LG 793

  Fly   544 GGPPPPPPPPMPGRAG----GPPPPPPPPGMGG---PPPPPMPGMMRPGG-GPPPPPMMMGPMVP 600
            ..||||||||.||.||    .|||||||||..|   |||||.|    ||| ..||||   |....
Zfish   794 SAPPPPPPPPPPGPAGLFSPPPPPPPPPPGFAGLASPPPPPPP----PGGLSIPPPP---GLFTT 851

  Fly   601 VLPHGLKP---KKKWDVKNPMKRANWKAIVPAKMSDK---------AFWVKCQEDKLAQDDFLAE 653
            ....||.|   ||:..||     ..||.:   |.||.         ..|...  ||:..|  .|:
Zfish   852 SPSQGLDPAFVKKRKTVK-----LFWKEL---KQSDSPRKCKFGRGTVWASL--DKVDVD--TAK 904

  Fly   654 LAVKFSSK----PVKKEQKDAVDKPTTLTKKNVDLRVLDSKTAQNLAIMLGGSLK---HLSYEQI 711
            |...|.||    ||.|:..:.         |...:.|||.|.:.  ||.:|.::.   |:    |
Zfish   905 LEHLFESKGKDLPVAKKGAEV---------KKAAISVLDPKRSN--AINIGMTVLPAIHV----I 954

  Fly   712 KICLLRCDTDILSSNILQQLIQYLPPPEHLKRLQEIKAKGE--PLPPIEQFAATIGEIKRLSPRL 774
            |..:|..|...:|...:::::...|..|..:::||.:....  ||...|||..|:..|..|:.||
Zfish   955 KSAILTFDEFAISKEGIEKILTMTPTEEEKQKIQEAQLANPDVPLGTAEQFLLTLSSISGLTARL 1019

  Fly   775 HNLNFKLTYADMVQDIKPDIVAGTAACEEIRNSKKFSKILELILLLGNYMNSGSKNEAAFGFEIS 839
            ....|||.|..:.::|...:.......|::..:|.|.:||..:|.:||::||    ..|.|||:.
Zfish  1020 QLWAFKLNYETLEKEIAEPLFDLKQGMEQLAKNKTFKRILATLLAIGNFLNS----SRAKGFELG 1080

  Fly   840 YLTKLSNTKDADNKQTLLHYLADLVEKKFPDALNFYDDLSHVNKASRVNMDAIQKAMRQMNSAVK 904
            ||.|::..||..::|:|||:..:.|.:.:||..:.|.::..:.::::|..:.:.:.:.|:.   :
Zfish  1081 YLEKVTEVKDTVHRQSLLHHTCNFVVENYPDTTDLYSEIPAITRSAKVEFEQLSENLIQLE---R 1142

  Fly   905 NLETDLQNNKVPQCDDDK--FSEVMGKFAEECRQQVDVLGKMQLQMEKLYKDLSEY-----YAFD 962
            ..:|...|.||....:.|  ....|.:|.::|.:::.:|..:..::...:.....|     |:..
Zfish  1143 KCKTSWDNLKVVAKHETKPNLKNKMTEFLKDCTERIIILKVVHRRIINRFHSFLLYLGHPSYSVR 1207

  Fly   963 PSKYT-----MEEFFADIKTFKD------------------------------------------ 980
            .:|.|     :.||..:.:|.::
Zfish  1208 DTKVTHFCKIISEFALEYRTTRERVLTQKRKRAVHRERTKTRGKLITETEKFSGAVTELSLDSSP 1272

  Fly   981 --AFQA------------------AHNDNVRVREELEKKRRLQEA-------------------- 1005
              .|.|                  |:|||..:|.....::.|..|
Zfish  1273 SPVFSAVESEPAQEEHENMKNLLIANNDNKLLRRSRAVRKILTTAGDTSPVSPSLQWSDEEEPCD 1337

  Fly  1006 ---------REQSAREQQE----RQQRKKAVVDMDAPQTQEGVMDSLLEALQTGSAFGQRNRQAR 1057
                     ..||||::.:    |.....:|...|:..:|:...|.:::.|.....   :|...|
Zfish  1338 SDSAHTSPVESQSARDEDDEGVGRLSTHMSVAKEDSASSQDDATDEIMDRLVKSVT---QNPTER 1399

  Fly  1058 RQRPAGAERRAQLSRSRSRTRVTNGQLMTREMILNEVLGSA 1098
            ...|. ..:|::|:|...|..:.:|  ::.|::....|||:
Zfish  1400 ASSPK-TRKRSRLNRKSLRRTLKSG--LSVEVVQALGLGSS 1437

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
dia	NP_001246113.1	Drf_GBD	66..248	CDD:461886
		Drf_FH3	253..453	CDD:461885
		FH2	608..983	CDD:396655	100/451 (22%)
fhod1	XP_021333585.2	None