Protein Alignment dia and fmnl1

DIOPT Version :10

• Sequence 1: NP_001246113.1
• Gene: dia / 35340
• FlyBaseID: FBgn0011202
• Length: 1098
• Species: Drosophila melanogaster
• Sequence 2: NP_001007523.1
• Gene: fmnl1 / 493573
• XenbaseID: XB-GENE-1003193
• Length: 1167
• Species: Xenopus tropicalis
• Alignment Length: 1350
• Identity: 307/1350 - (22%)
• Similarity: 505/1350 - (37%)
• Gaps: 479/1350 - (35%)

  Fly     9 SRHEKTKSTGGGLLDSLFGRPSKSKGGTISSGTLAHGGRPVSADNYVVPGVEDFEQYIQQLSVAE 73
            :|..:.:||.|       ..|.|.|.||.|...     ||.|                     .|
 Frog    13 ARDTRGQSTSG-------TPPQKQKEGTPSKLP-----RPNS---------------------VE 44

  Fly    74 LDAKFLEIIEDMNIPKDKREPLLAKSKEERQKMIMWHLKGKNSLERSANSRFE---KPIDYVE-- 133
            |:.:|..::..||:|.||.:.|....::::.:::            ....||:   .|..|::
 Frog    45 LEQRFNVVLNAMNLPPDKIQVLRQYDQDKKWELV------------CDQERFQVKNPPAAYIQKL 97

  Fly   134 --YLQNG----------EHSTHKVYQCVESLRVALTSNPISWIKEFGVAGIGTIEKLL------- 179
              ||..|          :.||    |.:..|.::|.:|.|.|::||....:|.::.|:
 Frog    98 RSYLDTGGISRKFKRRVQEST----QVLRELEISLRTNHIGWVEEFLSPEVGGLDALVEYLSYAQ 158

  Fly   180 -----------------------------------------ARSKN--------------NASYE 189
                                                     :||:|              |..:.
 Frog   159 GSCPIDTECSDNGTPEKSKSLQRSLEDINKSSSSPSPTNTPSRSRNLTARYNLHSRSTMRNTKHA 223

  Fly   190 KIEFE---AIRCLKAIMNNTWGLNVVLNPDQHSVVLLLAQSLDPRKPQTMCEALKLLASFCIVYE 251
            .::.:   .|.||:||||...|.::|::  ..|.|..:..||..:.|:|....|:|||:.|:|
 Frog   224 NMKDDVHVCIMCLRAIMNYQSGFSMVMS--HSSCVNKITLSLSNKNPRTKALVLELLAAVCLV-- 284

  Fly   252 RNGYEKVLRAITTI------AATSFKASERFRPIVDALFASDQQDPKRDLACHSLIFINTLTNTP 310
            |.|:|.:|.|....      .|...|..|.||          .:|...|.....:.|||.:.::.
 Frog   285 RGGHELILSAFNYFMEMCGEGARFEKLMEYFR----------TEDSNIDFMVACMQFINIVVHSV 339

  Fly   311 TDLNFRLHLRCEIMRMGLYDRLDEFTKIVEASNNENLQQHFKIFNEIREDDFEEFVQRFDNVTFN 375
            .::|||:.|:.|...:|    |||:.:|::.:.:|.||...:.:              .||:
 Frog   340 KNMNFRVFLQYEFTLLG----LDEYLEILKNTESERLQVQIQAY--------------LDNI--- 383

  Fly   376 MDDATDCFDVLKNLV-TDTTSEPYFLSILQHLLYIRDDFYFRPAYYQLIEECISQIVFHKGYCDP 439
                   |||...|. |||.:|     :|:|:..:::.
 Frog   384 -------FDVNSLLEDTDTKNE-----MLEHVEDLQEH--------------------------- 409

  Fly   440 NFENRNFNIDTSLLLDDIVEKAKAKES---KRSEEYEKKIEQ----LESAKQEAEAKAAHLEEKV 497
                          |..:.||.:..|:   :|..|.||:::|    :.|||::...:|..:.:.:
 Frog   410 --------------LTRVTEKLQLTENEYVRRVAELEKQLDQCRREMSSAKEKLVVQAPQVTQNI 460

  Fly   498 ----------------------------------------------------------------- 497
                                                                             
 Frog   461 VQRTELVKRSVLWVEPAGDTCTEEISDNTFTSDLPSAASTPPLSPSAIRITLISPSVTSTDALSS 525

  Fly   498 ---------------KLMEAN---GVAAPSP-----------NKLPKVNIPMPPPP--------- 524
                           .|.|::   .:.||||           .|..||| |:|.||
 Frog   526 RGNSPRSTTPPALLPSLPESSEIFSIPAPSPVPSSEDSSDTALKASKVN-PVPSPPSIIDQTQTS 589

  Fly   525 -------PGGGGAPPPPPPPMPGRAGGGPPP--------PPPPPMPGRAGGPPPPPPPPGMGGPP 574
                   ......|||||||:|..|...|||        |||||:|..:|.|||||.|.|..|.|
 Frog   590 NAQSLSRTHDESPPPPPPPPLPSIAEIPPPPPLPMSADVPPPPPLPELSGIPPPPPLPMGEQGAP 654

  Fly   575 PPPMPGMMRPG--GGPPPPPMMMGPMVP---------VLPHGLKPKKKWDVKNPMKRANWKAIVP 628
            ||| |.|..||  ..|||||...||..|         .|..|:..||....|..|:..||.|:.|
 Frog   655 PPP-PSMGAPGVPPPPPPPPSGFGPAPPPPPGGQPAATLNTGVSIKKPIQTKLRMQVLNWVALKP 718

  Fly   629 AKMSDKAFWVKCQEDKLAQDDFLAELAVKFSSKPVKKEQ-------KDAVDKPTTLTKKNVDLRV 686
            .:::...| ....::|:.|:..:::....|.:|.....|       |.|.::|..::       :
 Frog   719 TQINGTVF-THLNDEKVLQELDMSDFEENFKTKAQGPSQTTFSMKVKAAQNQPNKVS-------L 775

  Fly   687 LDSKTAQNLAIML--GGSLKHLSYEQIKICLLRCDTDILSSNILQQLIQYLPPPEHLKRLQEIKA 749
            :::..|:||||.|  ||    ||.|.|...:.:.|....:.:.|:.|.::||.....:::.....
 Frog   776 IETNRAKNLAITLRKGG----LSPEAITSAIQKYDMQAFNMDFLELLARFLPTDWERQQISRYCR 836

  Fly   750 KGEPLPPI---EQFAATIGEIKRLSPRLHNLNFKLTYADMVQDIKPDIVAGTAACEEIRNSKKFS 811
            ..:||..:   ::|...:..|.||:.|::.:.|...:.||...:||.:.|..||...|::|.|..
 Frog   837 DQKPLDDLTAEDRFMVHLCSIPRLAERVNTMTFMANFPDMASRLKPQLDALIAASMSIKSSDKLK 901

  Fly   812 KILELILLLGNYMNSGSKNEAAFGFEISYLTKLSNTKDADNKQTLLHYLADLVEKKFPDALNFYD 876
            .||||:|..|||||| ||..||:||.:..|..|..||..|.|||||||:..::.:|:....|||.
 Frog   902 GILELVLAFGNYMNS-SKRGAAYGFRLQSLDVLLETKSTDRKQTLLHYMIRVICEKYSHLSNFYC 965

  Fly   877 DLSHVNKASRVNMDAIQKAMRQMNSAVKNLETDLQNNKVPQCDDDKFSEVMGKFAEECRQQVDVL 941
            ||:.::||:.|::|::...::.:.:.::.::                        :|..:|.|.|
 Frog   966 DLNFMDKAATVSLDSVLADVKSLQAGMEQVQ------------------------KEFTKQDDCL 1006

  Fly   942 GKMQLQMEKLYKDLSEYYAFDPSKYTMEEFFADIKTFKDAFQAA---HNDNVR------------ 991
                     :.||.     ...:..::::..||.||.::|:.||   ..:|.:
 Frog  1007 ---------ILKDF-----IKSNMDSLKQLSADAKTAQEAYDAAVGYFGENAKTTPPSTFFPIFV 1057

  Fly   992 --------VREELEKKRRLQEAREQSAREQQERQQRKKAVVDMDAPQTQEGVMDSLLEALQTGSA 1048
                    ..::||..::.:.|.:::..|...:|..:..||....||.  .:|..|.:.|||
 Frog  1058 RFIKAYKQAEQDLETWKKQESAVQEAKPETAGKQAPQSPVVKSLRPQV--NLMAELNKKLQT--- 1117

  Fly  1049 FGQRNRQAR---------------RQRPAGAERRAQLSRSRSRTRVTNGQ 1083
                 ::.|               |.:|   .||..:.| ||..:..:||
 Frog  1118 -----KEPRVYEQNWAIEDIITDLRNQP---YRRTDVGR-RSGKKQNSGQ 1158

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
dia	NP_001246113.1	Drf_GBD	66..248	CDD:461886	51/263 (19%)
		Drf_FH3	253..453	CDD:461885	39/206 (19%)
		FH2	608..983	CDD:396655	102/386 (26%)
fmnl1	NP_001007523.1	Drf_GBD	37..283	CDD:461886	54/289 (19%)
		Drf_FH3	286..>423	CDD:461885	43/220 (20%)
		FH2	698..1064	CDD:396655	105/416 (25%)