Protein Alignment dia and fmnl2b

DIOPT Version :10

• Sequence 1: NP_001246113.1
• Gene: dia / 35340
• FlyBaseID: FBgn0011202
• Length: 1098
• Species: Drosophila melanogaster
• Sequence 2: XP_073809874.1
• Gene: fmnl2b / 492608
• ZFINID: ZDB-GENE-041111-182
• Length: 1111
• Species: Danio rerio
• Alignment Length: 1230
• Identity: 302/1230 - (24%)
• Similarity: 507/1230 - (41%)
• Gaps: 363/1230 - (29%)

  Fly    72 AELDAKFLEIIEDMNIPKDKREPLLAKSKEERQKMIMWHLKGKNSLERSANSRFE---KPIDYVE 133
            |||:.:|...:..||:|.||...|.....|::.::|            ....||:   .|..|::
Zfish    30 AELEERFAIALNTMNLPPDKVRILRQYDNEKKWELI------------CDQERFQVKNPPHTYIQ 82

  Fly   134 YLQN--GEHSTHKVY--------QCVESLRVALTSNPISWIKEF--------------------- 167
            .|::  ....|.|.:        |.:..|.::|.:|.|.|::||
Zfish    83 KLRSFLDPAVTRKKFRRRVQESTQVLRELEISLRTNHIGWVREFLNEENKGLDVLVEYLSFAQYA 147

  Fly   168 ------------GVAGIGT-----IEKL--------------LARS----------------KNN 185
                        |...:.|     ||.|              :.||                ||:
Zfish   148 VTFDGDVAESATGEISVETPWSRSIEDLHGDSNLPSPVSGSSIPRSTRHSLRSNTLPSRRTLKNS 212

  Fly   186 ASYEKIE--FEAIRCLKAIMNNTWGLNVVLNPDQHSVVLLLAQSLDPRKPQTMCEALKLLASFCI 248
            ....|.:  ...|.||:||||..:|.|:|:: ..|: |..:|.||:.:.|:|....|:|||:.|:
Zfish   213 RLVCKKDDVHVCIMCLRAIMNYQYGFNMVMS-HPHA-VNEIALSLNNKNPRTKALVLELLAAVCL 275

  Fly   249 VYERNGYEKVLRAITTIAATSFK----ASERFRPIVDALFASDQQDPKRDLACHSLIFINTLTNT 309
            |  |.|:|.:|.|.     ..||    .::||..:::. |.::..:....:||  :.|||.:.::
Zfish   276 V--RGGHEIILAAF-----DHFKEVCSETQRFEKLMEH-FKNEDNNIDFMVAC--MQFINIVVHS 330

  Fly   310 PTDLNFRLHLRCEIMRMGLYDRLDEFTKIVEASNNENLQQHFKIFNEIREDDFEEFVQRFDNVTF 374
            ..|:|||:||:        ||    |||:       :|..:.:.......|..:..:|.:
Zfish   331 VEDMNFRVHLQ--------YD----FTKL-------SLDDYLERLKHTESDKLKVQIQAY----- 371

  Fly   375 NMDDATDCFDVLKNLVTDTTSEPYFLSILQHLLYIRDDFYFRPAYYQLIE---ECISQIVFHKGY 436
             :|:..|...:|::..|...:......:.::|.::.|         :|:|   |.:|:||    .
Zfish   372 -LDNLFDVGTLLEDAETKNAALERVEELEENLSHMSD---------KLLETENEAMSKIV----E 422

  Fly   437 CDPNFENRNFNIDT--------SLLLDDI--VEKAKAKESKRSEEYEKKIEQLESAKQEAEAKAA 491
            .:.....:|..:||        |..:..:  :.:.|.:..::....||||.:||        :..
Zfish   423 LEKQLMQKNKELDTVRAVYRDASSQVHTLRRIVREKDETIQKQSTLEKKIHELE--------RRG 479

  Fly   492 HLEEKVKLMEANGVAAPSPNKLPKVNIPMPP---------------------------------- 522
            .|:.:|: .|.:|....||       :|.||
Zfish   480 SLQIQVR-GEGDGEGDVSP-------LPSPPQPMALSPCPDAMALAGACAGASYSSASSSQTGTL 536

  Fly   523 -----PPPGGGGAPPPPPPPMP------GRAGGGPPPPPPPPMPGRAGGPPPPPPPPGMGGPPPP 576
                 |||     ||||||||.      |.:...||||||||       ||||||||    ||||
Zfish   537 RAMVTPPP-----PPPPPPPMTDSSVPNGPSAALPPPPPPPP-------PPPPPPPP----PPPP 585

  Fly   577 PMPGMMRPGGGPPPPPMMMGPMVPVLPHGLKP------------KKKW---DVKNPMKRA----- 621
            |...:......|||||    |..|.||....|            .:.|   .:|.|:|..
Zfish   586 PGHSIEISAPLPPPPP----PCAPPLPGSGTPTVIFNSGLTGMYMQMWVSVKIKKPIKTKFRMPV 646

  Fly   622 -NWKAIVPAKMSDKAFWVKCQEDKLAQDDFLAELAVKFSSKPVKKEQKDAVDKPTTLTKKNV--- 682
             ||.|:.|.:::...| .:..::::.:|..:.|....|.:    |.|..|||  .||.|:..
Zfish   647 FNWVALKPNQINGTVF-NEIDDERILEDLNVDEFEEMFKT----KAQGPAVD--MTLQKQKAPQK 704

  Fly   683 ---DLRVLDSKTAQNLAIMLGGSLKHLSYEQIKICLLRCDTDILSSNILQQLIQYLPPPEHLKRL 744
               .:.:|::..|:||||.|..:.|  |.|:|...:...|...:..:.::.|::::|....:|.|
Zfish   705 GPNKVSLLEANRAKNLAITLRKAGK--SPEEICKAIQTFDLRTVPVDFVECLMRFMPTESEVKVL 767

  Fly   745 QEIKAKGEPLPPI---EQFAATIGEIKRLSPRLHNLNFKLTYADMVQDIKPDIVAGTAACEEIRN 806
            ::.:.:..|:..:   ::|.....:|:||..|:..:.|...:.|.:|.:.|.:.|..||...|::
Zfish   768 RQYERERRPMDGLTDEDRFMMLFSKIERLPQRMTIMAFMGNFTDSLQMLTPQLHAIIAASVSIKS 832

  Fly   807 SKKFSKILELILLLGNYMNSGSKNEAAFGFEISYLTKLSNTKDADNKQTLLHYLADLVEKKFPDA 871
            |:|..||||:||.||||||| ||..|.:||::..|..|..||..|.|||||||:|::|::|:|..
Zfish   833 SQKLKKILEIILALGNYMNS-SKRGAVYGFKLQSLDLLLETKSTDRKQTLLHYIANVVKEKYPIV 896

  Fly   872 LNFYDDLSHVNKASRVNMDAIQKAMRQM----------------NSAVKN--------LETDLQN 912
            ..||::|.::.||:.|:::.:...:|::                ||.:|:        |:..|.:
Zfish   897 SIFYNELHYIEKAAAVSLENVLLDVRELQRGMDLTKREYSMHGHNSLLKDFIHHNEARLKKLLDD 961

  Fly   913 NKVPQCDDDKFSEVMGKFAEECRQQVDVLGKMQLQMEKLYKDLSEYYAFDPSKYTMEEFFADIKT 977
            .|:.|   |.|.|.:..|.|..:..                         |.......|...||:
Zfish   962 AKIAQ---DAFDEAVKFFGESAKTM-------------------------PPSVFFPVFVRFIKS 998

  Fly   978 FKDAFQAAHNDNVRVREE-------LEKKRRLQEAREQSAREQQERQQRKKAVVDM------DAP 1029
            ::   ||...:.:|.|:|       :|::..::|...|.:...:.::|:::.:.::      |:.
Zfish   999 YR---QADEENELRKRQEQLMMEKLMEQEAMMEEQESQQSPSHKGKRQQQELIHELRKRQGKDSR 1060

  Fly  1030 QTQEGVMDSLLEALQTGSAFGQRNRQARRQRPAGAERRAQLSRSRSRTRVTNGQLMTREM 1089
            ...|| .|..:|.:.|    ..||:..||   |.|.||:    .|....|.:.||.|.|:
Zfish  1061 LVYEG-KDGAIEDIIT----DLRNQPFRR---ADALRRS----GRRNLEVQHLQLRTVEI 1108

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
dia	NP_001246113.1	Drf_GBD	66..248	CDD:461886	58/258 (22%)
		Drf_FH3	253..453	CDD:461885	44/214 (21%)
		FH2	608..983	CDD:396655	110/428 (26%)
fmnl2b	XP_073809874.1	None