DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dia and FAM47C

DIOPT Version :9

Sequence 1:	NP_001246113.1	Gene:	dia / 35340	FlyBaseID:	FBgn0011202	Length:	1098	Species:	Drosophila melanogaster
Sequence 2:	NP_001013758.1	Gene:	FAM47C / 442444	HGNCID:	25301	Length:	1035	Species:	Homo sapiens

Alignment Length:	448	Identity:	94/448 - (20%)
Similarity:	148/448 - (33%)	Gaps:	122/448 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   504 GVA--APSPNKLPKVNIPMPPPPPGGGGAPPPPP----------PPMPGRAGGGPPPP------- 549
            ||:  .|.|.|....::|..||..|.....|.||          ||..|.:...|.||
Human   578 GVSHLCPEPPKTRVSSLPPEPPETGVSHLCPEPPETRVSHLRPEPPETGVSHLRPEPPKTRMYSL 642

  Fly   550 -PPPPMPG-----------RAGGPPPPPPPPGMGG-------------PPPPPMPGMMRPGGGPP 589
             |.||..|           |....||.||..|:..             .|.||..|:.|....||
Human   643 RPEPPNTGVSHLCPEPPKTRVSSLPPEPPETGVSHLCPEPPETRVSHLRPEPPETGVSRLHPEPP 707

  Fly   590 ----------PPPMMMGPMVPVLPH----GLKPKKKWDVKNPMKRANWKAIVPAKMSDKAFWVKC 640
                      ||...:..:.|..|.    .|:|:.      |..|.:  ::.|..:..:...::.
Human   708 KTRVSSLHAEPPESRVSHLCPEPPETGVSHLRPEP------PKPRVS--SLRPEPLETRVSHLRP 764

  Fly   641 QEDKLAQDDFLAELAVKFSSKPVKKEQKDAVDKPTTLTKKNVDLRVLDSKTAQNLAI-----MLG 700
            :.         .|..|......:.|.:..::......|::...||:...||.:..::     ..|
Human   765 EP---------PETGVSHLHPELPKPRVSSLHLEPPKTRRVSSLRLEPPKTGRVSSLCPEPTKTG 820

  Fly   701 GS-LKHLSYEQIKICLLRCDTDILSSNILQQLIQYLPPPEHLKR-LQEIKAKGEPLPPIEQFAAT 763
            .| ||.| :::.....:.|.:|.|..             .|..| |::.|..|: |...|:   :
Human   821 ASHLKEL-FQEGTSSTMECVSDSLQR-------------RHTSRKLRDFKWAGD-LGVNEE---S 867

  Fly   764 IGEIKRLSPRLHNLNFKLTYADMVQDIKPDIVAG---TAACEEIRNSKKFSKILELILLLGNYMN 825
            |..:...:|..     :.||.|.......:..:|   :...:|:...|.||:..:|...:.|..|
Human   868 ISSLFDFTPEC-----RATYQDQKNKKANECSSGLKYSMELDEMDEVKFFSQEKDLDGKIQNAPN 927

  Fly   826 SGSKNEAAFGFEISYL-TKLSNTKDADNKQTLLHYLADLVEKKF----PDALNFYDDL 878
            |.|......|:...|| .||.....:|.         .|::.|.    ||..:..|.|
Human   928 SHSAQHVKMGYGAWYLKPKLGKKLRSDE---------PLIDPKLVLEKPDEPDILDGL 976

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dia	NP_001246113.1	Drf_GBD	66..248	CDD:283920
		Drf_FH3	253..453	CDD:283917
		FH2	608..983	CDD:280362	54/286 (19%)
FAM47C	NP_001013758.1	FAM47	1..257	CDD:291315
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..21
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	159..797		48/235 (20%)
		FAM47	<365..509	CDD:291315
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165156519
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.930