Protein Alignment dia and fmnl3

DIOPT Version :10

• Sequence 1: NP_001246113.1
• Gene: dia / 35340
• FlyBaseID: FBgn0011202
• Length: 1098
• Species: Drosophila melanogaster
• Sequence 2: NP_001333083.1
• Gene: fmnl3 / 407694
• ZFINID: ZDB-GENE-030131-1571
• Length: 1047
• Species: Danio rerio
• Alignment Length: 1135
• Identity: 287/1135 - (25%)
• Similarity: 483/1135 - (42%)
• Gaps: 267/1135 - (23%)

  Fly    56 VPGVEDFEQYIQQLSV-----AELDAKFLEIIEDMNIPKDKREPLLAKSKEERQKMIMWHLKGKN 115
            |.|..:.:.:|..|.|     .||:.:|..::..||:|.||...|.....|::..:|
Zfish     7 VDGQSEMKHHIMPLKVPMPDPTELEERFAIVLNSMNLPPDKARLLRQYDNEKKWDLI-------- 63

  Fly   116 SLERSANSRFE---KPIDYVEYLQN--GEHSTHKVY--------QCVESLRVALTSNPISWIKEF 167
                ....||:   .|..|::.|:.  ....|.|.:        :.:..|.::|.:|.|.|::||
Zfish    64 ----CDQERFQVKNPPHTYIQKLRGYLDPKVTRKKFRRRVQESTKVLRELEISLRTNHIGWVREF 124

  Fly   168 ------------------------GVAGI---------------GTIEKL-------LARS---- 182
                                    ...|:               .:||.|       |.||
Zfish   125 LNDENRGLDILVEYLSFAQCAVMLDFEGLENGEDFSLDKAKSWSRSIEDLHQNGCNTLVRSARQS 189

  Fly   183 -------------KNN--ASYEKIEFEAIRCLKAIMNNTWGLNVVLNPDQHS-VVLLLAQSLDPR 231
                         ||:  .|.:......|.||:||||..:|.|:|::   |: .|..:|.||:.:
Zfish   190 VLRYGSTSNSKTIKNSRLVSQKDDVHVCIMCLRAIMNYQYGFNLVMS---HAHAVNEIALSLNNK 251

  Fly   232 KPQTMCEALKLLASFCIVYERNGYEKVLRAITTIAATSFKASERFRPIVDALFASDQQDPKRDLA 296
            .|:|....|:|||:.|:|  |.|:|.:|.|........ |...||..::: .|.|:..:....:|
Zfish   252 NPRTKALVLELLAAVCLV--RGGHEIILSAFDNFKEVC-KEKHRFEKLME-YFRSEDGNIDFMVA 312

  Fly   297 CHSLIFINTLTNTPTDLNFRLHLRCEIMRMGLYDRLDEFTKIVEASNNENLQQHFKIFNEIREDD 361
            |  :.|||.:.::..|:|||:||:.|..::|    ||:|.:..:.:.::.|....:.:
Zfish   313 C--MQFINIVVHSVEDMNFRVHLQYEFTKLG----LDDFLEKSKHTESDKLSVQIQAY------- 364

  Fly   362 FEEFVQRFDNVTFNMDDATDCFDV--------LKNLVTDTTSEPYFLSILQHLLYIRDDFYFRPA 418
                   .|||          |||        .||:..:...|     :.:||.::.:
Zfish   365 -------LDNV----------FDVGGLLEDAETKNVALEKVEE-----LEEHLSHVTE------- 400

  Fly   419 YYQLIE---ECISQI------VFHK----GYCDPNFENRNFNIDTSLLLDDIVEKAKAKESKRSE 470
              :|::   |.::::      :.||    ......:|:.:..:.|  |...|.||..|  .:|..
Zfish   401 --KLLDVENETMTKVADLEKQLLHKDKELAVIKETYESASTQVHT--LRRMIQEKDAA--FQRHN 459

  Fly   471 EYEKKIEQLESAKQEAEAKAAHLEEKVKLMEANGVAAPSPNKLPKVNIPMPPPPPGG-GG----- 529
            ..||::.:||........|....:..::.:.|..||......|..:.:.|  ...|| ||
Zfish   460 NIEKQLLELEQQGTIRLRKQPDGDIAIETLGAGAVAGTPLTDLRSLTVGM--STIGGLGGTSAVP 522

  Fly   530 ----APPPPPPPMPGRAGGGPPPPPPPPMPGRAGGPPPPPPPPGMGGPPPPPMPGMMRPGGGPPP 590
                ||||||||.|      |||||.||:|......|.||       |||||:||         |
Zfish   523 VEAVAPPPPPPPPP------PPPPPAPPLPSEVESIPIPP-------PPPPPLPG---------P 565

  Fly   591 PPMMMGPMVPVLPHGLKPKKKWDVKNPMKRA------NWKAIVPAKMSDKAFWVKCQEDKLAQDD 649
            .|.:      :|..||...:   :|.|:|..      ||.|:.|.:::...|      :::..|.
Zfish   566 SPSV------ILSVGLSAIR---IKKPIKTKFRLPVFNWTALKPNQINGTVF------NEIDDDR 615

  Fly   650 FLAELAV-KFSSKPVKKEQKDAVD---KPTTLTKKNVD-LRVLDSKTAQNLAIMLGGSLKHLSYE 709
            .|.||.: ||......|.|...||   ..:.:::|.:: :::||:..::||||.|..:.|  :.|
Zfish   616 VLEELDLEKFEELFKTKAQGPVVDLSCSKSKVSQKVINKVQLLDANRSKNLAITLRKANK--TTE 678

  Fly   710 QIKICLLRCDTDILSSNILQQLIQYLPPPEHLKRLQEIKAKGEPLPPI---EQFAATIGEIKRLS 771
            :|...:...|...|..:.::.|:::||.....|.|::.:.:..||..:   ::|.....:|:||:
Zfish   679 EICKAIQTFDLKALPVDFVECLMRFLPTEAESKLLRQYERERRPLDQLAEEDRFMLLFSKIERLT 743

  Fly   772 PRLHNLNFKLTYADMVQDIKPDIVAGTAACEEIRNSKKFSKILELILLLGNYMNSGSKNEAAFGF 836
            .|:..:.|...:.|.|..:.|.:.|..||...:::|.|..||||:||.||||||| ||..:.:||
Zfish   744 QRMSIITFVGNFNDNVNMLTPQLNAIIAASASVKSSPKLKKILEIILALGNYMNS-SKRGSVYGF 807

  Fly   837 EISYLTKLSNTKDADNKQTLLHYLADLVEKKFPDALNFYDDLSHVNKASRVNMDAIQKAMRQMNS 901
            ::..|..|.:||..|.|.|||||:|.:|::|:|:..|||::|..|:||:.|:::.:...::::..
Zfish   808 KLQSLDLLLDTKSTDRKMTLLHYIALVVKEKYPELANFYNELHFVDKAAAVSLENVLLDVKELGK 872

  Fly   902 AVKNLETDLQNNKVPQCDDDKFSEVMGKFAEECRQQVDVLGKMQLQMEKLYKDLSEYYAFDPSKY 966
            .:     ||...:....|    ..|:..||:....|:|.|.|.....|:.:.::..|:...|...
Zfish   873 GM-----DLVRRECSLHD----HAVLKGFAQTSDTQLDKLAKDAKTAEEAFNNVVLYFGESPKTT 928

  Fly   967 TMEEFFADIKTFKDAFQAAHNDNVRVREELEKKRRLQEAREQSAREQQERQQRKKAVVDMDAPQT 1031
            ....||.....|..|::.|..:|       |::::.:||..:....|:.:|...|........|.
Zfish   929 PPSVFFPVFVRFIRAYKEAVEEN-------EQRKKQEEAMREKLLAQEAKQHDPKVQAQKKRHQQ 986

  Fly  1032 QEGVMDSLLEALQTGSAFGQRNRQARRQRP 1061
            ||     |:..|        |.|||:..||
Zfish   987 QE-----LIAEL--------RRRQAKDHRP 1003

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
dia	NP_001246113.1	Drf_GBD	66..248	CDD:461886	59/265 (22%)
		Drf_FH3	253..453	CDD:461885	43/220 (20%)
		FH2	608..983	CDD:396655	109/388 (28%)
fmnl3	NP_001333083.1	Drf_GBD	23..268	CDD:461886	56/259 (22%)
		Drf_FH3	271..462	CDD:461885	49/240 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	520..561		23/53 (43%)
		FH2	580..945	CDD:396655	109/382 (29%)
		CwlO1	<941..>999	CDD:443091	17/77 (22%)