DRSC/TRiP Functional Genomics Resources

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Protein Alignment dia and Frl

DIOPT Version :9

Sequence 1:NP_001246113.1 Gene:dia / 35340 FlyBaseID:FBgn0011202 Length:1098 Species:Drosophila melanogaster
Sequence 2:NP_729954.2 Gene:Frl / 39561 FlyBaseID:FBgn0267795 Length:1183 Species:Drosophila melanogaster


Alignment Length:1294 Identity:294/1294 - (22%)
Similarity:481/1294 - (37%) Gaps:389/1294 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly    28 RPSKSKGGTISSGTLAHGGRPVSADNYVVPGVEDFEQYIQQLSVA-----------ELDAKFLEI 81
            |......|:||||||.      ..|.....|.....|:::|.|:.           |||.:|.::
  Fly    33 RNGHQHNGSISSGTLQ------KQDLRYDIGCSSQYQHVRQPSLRSRSQQPMPTTDELDRRFAKV 91

  Fly    82 IEDMNIPKDKREPLLAKSKEERQKMIMWHLKGKNSLERSANSRFEKPIDYVE----YLQNGEHST 142
            :..|::|.||.:.|.....|::..||         .::......:.|..|:.    ||......:
  Fly    92 LASMDLPPDKAKLLRNYDDEKKWDMI---------CDQEMVQAKDPPSHYLSKLRTYLDPKASRS 147

  Fly   143 HKVY------------------QCVESLRVALTSNPISWIKEF---------------------- 167
            |::|                  |.:..|.::|.:|.|.|:|||                      
  Fly   148 HRLYLFYFLCQKRKMVGESTSTQVLRDLEISLRTNHIEWVKEFLDDTNQGLDALVDYLSFRLQMM 212

  Fly   168 ---------------------------------------GVAGI-------------GTIEKLLA 180
                                                   |..|:             ||::   :
  Fly   213 RHEQRLQGVLCASEERLNLTNGGDGGEIVMGNSSSVSPGGGGGLLSHGNSTGHGLANGTLD---S 274

  Fly   181 RSKNNASY-----------------------EKIEFEA--------IRCLKAIMNNTWGLNVVLN 214
            |.::..||                       .|:...|        |.||:|||||.:|.|:|: 
  Fly   275 RQQHTMSYGFLRPTIADALDSPSLKRRSRHIAKLNMGAATDDIHVSIMCLRAIMNNKYGFNMVI- 338

  Fly   215 PDQH-SVVLLLAQSLDPRKPQTMCEALKLLASFCIVYERNGYEKVLRAITTIAATSFK----ASE 274
              || ..:..:|.||..:..:|....|:|||:.|:|  :.|:|.:|.:.     .:||    ...
  Fly   339 --QHREAINCIALSLIHKSLRTKALVLELLAAICLV--KGGHEIILGSF-----DNFKDVCQEKR 394

  Fly   275 RFRPIVDALFASDQQDPKRDLACHSLIFINTLTNTPTDLNFRLHLRCEIMRMGLYDRLDEFTKIV 339
            ||:.:::.....:..:....:||  :.|:|.:.::..|:|:|:||:.|...:|    ||::.:.:
  Fly   395 RFQTLMEYFMNFEAFNIDFMVAC--MQFMNIVVHSVEDMNYRVHLQYEFTALG----LDKYLERI 453

  Fly   340 EASNNENLQQHFKIFNEIREDDFEEFVQRFDNVTFNMDDATDCFDVLKNLVTDTTSEPYFLSILQ 404
            ..:.:|.|:.....:              .|||          |||.. |:.|:.::...|..:|
  Fly   454 RLTESEELKVQISAY--------------LDNV----------FDVAA-LMEDSETKTSALERVQ 493

  Fly   405 HLLYIRDDFYFRPAYYQLIEECISQIVFHKGYCDPNFENRNFNIDTSLLLDDIVEKAKAKESKRS 469
            .|    :|        ||..|......|...|.:...|        ||.|....|:......|..
  Fly   494 EL----ED--------QLEREIDRNSEFLYKYAELESE--------SLTLKTEREQLAMIRQKLE 538

  Fly   470 EEYEKKIEQLESAKQEAEAKAAHLEEKVKLMEANGVAAPSPNKLPKVNIPMPPPPPGGGGA---- 530
            ||.......|:..:||       |:::..|:....:      :|..::..:|.....|.|:    
  Fly   539 EELTVMQRMLQHNEQE-------LKKRDTLLHTKNM------ELQTLSRSLPRSASSGDGSLANG 590

  Fly   531 --------------PPPPPPPMPG--RAGGGPPPPPPPPMPGRAGGPPPPPPPPG---MGGP--- 573
                          .||||||||.  .|....|||||||      .||.||||||   :|.|   
  Fly   591 GLMAGSTSGAASLTLPPPPPPMPASPTASSAAPPPPPPP------APPAPPPPPGFSPLGSPSGS 649

  Fly   574 -----PPPPMPGMMRPGGGPPPPPMMMGPMVPVLPHGLKPKKKWDVKNPMKRANWKAIVPAKMSD 633
                 |.||....|.....|||||  :...:|.....:..|:|...|..:...||.|:.|.::..
  Fly   650 LASTAPSPPHAPPMLSSFQPPPPP--VAGFMPAPDGAMTIKRKVPTKYKLPTLNWIALKPNQVRG 712

  Fly   634 KAFWVKCQEDKLAQDDFLAELAVKF----------------------SSKPVKKEQKDAVDKPTT 676
            ..|.....|....|.|| .|...:|                      |||..|:....::.:.|.
  Fly   713 TIFNELDDEKIFKQIDF-NEFEERFKIGIGGALRNGSNGTEVDGSLQSSKRFKRPDNVSLLEHTR 776

  Fly   677 LTKKNVDLRVLDSKTAQNLAIMLGGSLKHLSYEQIKICLLRCDTDILSSNILQQLIQYLPPPEHL 741
            |....:..|.|.......:|.:....||.||.|.::              :||:::   |....:
  Fly   777 LRNIAISRRKLGMPIDDVIAAIHSLDLKKLSLENVE--------------LLQKMV---PTDAEV 824

  Fly   742 KRLQE--IKAKGEPLPPIE-QFAATIGEIKRLSPRLHNLNFKLTYADMVQDIKPDIVAGTAACEE 803
            |..:|  |:.|.:.|...| :|...:..::|:|.:|..:|:...:.|.|..|.|.:.:...|...
  Fly   825 KSYKEYIIERKDQQLLTEEDKFMLQLSRVERISSKLAIMNYMGNFVDSVHLISPQVQSIAGASTS 889

  Fly   804 IRNSKKFSKILELILLLGNYMNSGSKNEAAFGFEISYLTKLSNTKDADNKQTLLHYLADLVEKKF 868
            ::.|:||..:||::|..|||:|| :|...|:||::..|..|.:||..|.:.:||||:...:..||
  Fly   890 LKQSRKFKAVLEIVLAFGNYLNS-NKRGPAYGFKLQSLDTLIDTKSTDKRSSLLHYIVATIRAKF 953

  Fly   869 PDALNFYDDLSHVNKASRV--------------NMDAIQK-AMRQMNSAVKNLETDLQNNKVPQC 918
            |:.|||..:|...:||:.|              .||.::| |..::..|..::..|..||     
  Fly   954 PELLNFESELYGTDKAASVALENVVADVQELEKGMDLVRKEAELRVKGAQTHILRDFLNN----- 1013

  Fly   919 DDDKFSEVMGKFAEECRQQVDVLGKMQLQ-MEKLYKDLSEYYAFDPSKYTMEEFFADIKTFKDAF 982
            .:||..::                |..|: .::.:|:..||:...........|||.|..|..||
  Fly  1014 SEDKLKKI----------------KSDLRHAQEAFKECVEYFGDSSRNADAAAFFALIVRFTRAF 1062

  Fly   983 QAAHNDNVRVREELEKKRRLQEAREQSAREQQERQ--------QRKKAVVDMDAPQTQEGVMDSL 1039
            :....:|       |::.||::|...:|.:::..|        |:|:.:....|...||.|::.|
  Fly  1063 KQHDQEN-------EQRLRLEKAAALAASKKENDQVLMRNKVNQKKQQLPSNGALSLQEAVINEL 1120

  Fly  1040 LEALQTGSAFGQRNRQARRQRPA--GA------------ERRAQLSRSRSRTRVTNGQL 1084
                 ...|...|.::..:|...  ||            .|||...|...|.|:.|.:|
  Fly  1121 -----KSKAHSVREKKLLQQDEVYNGALEDILLGLKSEPYRRADAVRRSQRRRIDNNRL 1174

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
diaNP_001246113.1 Drf_GBD 66..248 CDD:283920 59/320 (18%)
Drf_FH3 253..453 CDD:283917 41/203 (20%)
FH2 608..983 CDD:280362 102/415 (25%)
FrlNP_729954.2 Drf_GBD 77..371 CDD:283920 57/308 (19%)
Drf_FH3 374..567 CDD:283917 52/255 (20%)
FH2 687..1063 CDD:280362 102/415 (25%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C45463914
Domainoid 1 1.000 79 1.000 Domainoid score I2351
eggNOG 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 116 1.000 Inparanoid score I2015
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000085
OrthoInspector 1 1.000 - - mtm9222
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R3069
SonicParanoid 00.000 Not matched by this tool.
76.920

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