DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dia and Fhos

DIOPT Version :9

Sequence 1:	NP_001246113.1	Gene:	dia / 35340	FlyBaseID:	FBgn0011202	Length:	1098	Species:	Drosophila melanogaster
Sequence 2:	NP_001163387.2	Gene:	Fhos / 39004	FlyBaseID:	FBgn0266084	Length:	2528	Species:	Drosophila melanogaster

Alignment Length:	1472	Identity:	288/1472 - (19%)
Similarity:	490/1472 - (33%)	Gaps:	474/1472 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 KKLGMSRHEKTKSTGGGL---LDSLF---GRPSKSKGGTISSGTLAHGGRPVSADNYVVPG---V 59
            :||.:|||:......||.   |..||   ..|::|:...::       |:.:.....|.|.   :
  Fly  1101 EKLFISRHQNIDELLGGACRPLSPLFYGNSNPAESELTPLA-------GKNMFLLEEVTPDQVRI 1158

  Fly    60 EDFEQYIQQLSVAELDAKFLEIIEDMNIPKDKR---------------------------EPLLA 97
            .|....:..:...:.|.::|:...:...|.::|                           |..||
  Fly  1159 HDSTAQLPVIQRMQRDVEWLDNGSNFYEPPEQRQHQPPRRIDDAAIQVYKDGDYGAYLDLESSLA 1223

  Fly    98 KSKEERQKMIMWHLKGKNSL--ERSANSRFEKPIDYVEYLQNGE-----HSTHKVYQCVESLRVA 155
            :..||.:.:   ::..||||  ....|.|.:..|:.:...|..:     .|..:|:|..:.|..|
  Fly  1224 EQAEEIEGV---NVSRKNSLVVRTQLNVRVQAIIEKLLSAQGSDLRRALFSLKQVFQEDKDLVHA 1285

  Fly   156 LTSNPISWIKEFGVAGIGTIEKLLARSKNNASYEKIEFEAIRCLKAIMNNTWGLNVVLNPDQHSV 220
            ..:          :.|:..:.::     .|.:.:..:...:|.|..:|....|:|.|:   :|..
  Fly  1286 FVA----------LGGLNCLVRV-----GNCADQNYQNYILRALGQVMLYVDGMNGVM---KHEP 1332

  Fly   221 VLLLAQSLDPRKPQTMCE-ALKLLASFCIVYERNGYEKVLRAITTIAATSFKASERFRPIVDAL- 283
            .:....||.....:::.: |||||..|....|.|.|      :...|..:..||:...|..:.:
  Fly  1333 TMQWLYSLIASNYRSVVKTALKLLLVFVEYAESNCY------VLVSAIHAVDASQGTLPWSNIMR 1391

  Fly   284 FASDQQDPKRDLACHSLIFIN-TLTN--------TPTDLNFRLHLRCEIMR--------MGLYDR 331
            ...|..:...:|..::...|| ||..        ..:||..:..:...|.|        :.|.|:
  Fly  1392 LLKDYDNADAELVIYATSLINKTLAGLNDQDSFYDESDLLEQQGMETVIQRYMSKPGTDLDLLDQ 1456

  Fly   332 LDEFTKIVE----ASNNENLQQHFKIFNEIREDDFEEFVQRF---DNVTFNMDDATDCFD----- 384
            |..:..:::    .|:.:.|.|     |.:|:      .||:   .|.|..........|
  Fly  1457 LQLYEAVLKFEDGESDGQRLPQ-----NSMRK------TQRYRPGANTTERRKSRRHSTDNSPAS 1510

  Fly   385 ---VLKNLV--------------TDTTSEPYFLSILQHLLYIRDDFYFRPAYYQLIE-------- 424
               ||...|              :.:|:...|...|.:....||.....|...:..|
  Fly  1511 LTKVLPTTVLRMTPTQATVDEDSSGSTNSTEFSGGLFNEKKPRDGAGVTPGLRRRRERAERHKSF 1575

  Fly   425 -------------------ECISQIV------FHKGYCDP-----------------NFENRNF- 446
                               |.:.|||      ...|...|                 |..|.|.
  Fly  1576 LKEQQEAAANGIFAALEQREGLGQIVTAIPATIQTGDSPPQSLQHEVPPCNNISGITNISNNNVS 1640

  Fly   447 NI---DT---SLLL-------------DDIVEKA--KAKESKRSEEYEKK--------------- 475
            |:   ||   |||:             ..|:..:  ||..:.:||...||
  Fly  1641 NLSCNDTPNNSLLVMSPSKQLLTGSHSISIINNSFDKASNNNQSEFLTKKNLFRERNSTVINGIM 1705

  Fly   476 --IEQLESAKQEAEAKAAHLEEKVKLMEANGVAAP---------SPNK-LPKVNIPMPPPP---- 524
              |:|.:||.::.|.:|..|.........:.:..|         ||.| |........|.|
  Fly  1706 KNIQQTDSAYKKYENEANRLNNYYSQSPKHQIHQPIQPTPEVLLSPKKTLNASGFDFTPAPLSST 1770

  Fly   525 PGGGGAPPPPPPPMPGRAGGGPPPPPPPPMPGRAGGPPPPPPPPGMGGPP--------------- 574
            |.....||.|.|..|.:.....|||||||       |||||||||....|
  Fly  1771 PVKCDVPPEPEPLSPVKKPAAAPPPPPPP-------PPPPPPPPGWWHAPIYNSPQARTLTSTNP 1828

  Fly   575 ---PPP-------------------------------------------------MPG------- 580
               |.|                                                 |.|
  Fly  1829 ELLPHPVDPSDMESEDQQLLLQLKRDHTVKDLTQKLSNLPMSPTQDSANRALVGDMSGLISKAKE 1893

  Fly   581 -----------------------------------------MMRP-------------------- 584
                                                     |.||
  Fly  1894 GLAKSKSKGEISRSSSVDQDVKKSEPKKSENELHWEELVRNMTRPLNLCDLDFTDLRDDDEKDVL 1958

  Fly   585 -----GGGPPPPPMMMGPMV---PVLPHGLKPKKKW----DVKNPMKRANW----------KAIV 627
                 |.|.||||..:|..:   |::|..|.|...:    .:.|.:...|.          ..|.
  Fly  1959 APRSLGAGIPPPPPPLGGAIAPPPMMPPSLAPPPMYGYGGSLTNSVNSLNGSINGELVNGNNTIK 2023

  Fly   628 PAKMSDKAFWVKCQEDKLAQ-------DDF------LAELAVKFSSKPVKKEQKDAVDKPTTLTK 679
            ..|.:.|.||.:.:||.:.|       |:.      ..:|...|.|:     .||.:.|......
  Fly  2024 KNKKTVKLFWKEVREDMIPQVVGKTIWDELPDANVDTQKLEHLFESR-----AKDLMTKKQQELN 2083

  Fly   680 KNVDLRVLDSK--TAQNLAIMLGGSLKHLSYEQIKICLLRCDTDILSSNILQQLIQYLPPPEHLK 742
            |:.::.|||.|  .|.|:||     .|......||..:|:.|..:::...:.:|:..||..|...
  Fly  2084 KSKEIIVLDHKRSNAINIAI-----TKLPPPRAIKTAILKMDATVVTREGIDKLLNMLPTDEERG 2143

  Fly   743 RLQEIKAKGEPLP--PIEQFAATIGEIKRLSPRLHNLNFKLTYADMVQDIKPDIVAGTAACEEIR 805
            ::||.:.....||  ..|||..|:..|..|..||....|:|.:.:..::|...::......|.:|
  Fly  2144 KIQEAQLSNPELPLGSAEQFLLTLASISELEARLKLWAFRLDFDNSEKEIAEPLMDLKQGIEILR 2208

  Fly   806 NSKKFSKILELILLLGNYMNSGSKNEAAFGFEISYLTKLSNTKDADNKQTLLHYLADLVEKKFPD 870
            .::.|..||..:|.:|.::|.....    ||:|.||.|:...||..:|.:|||:|..:|.:...|
  Fly  2209 QNRTFRSILSTLLSVGIFLNGAPVK----GFQIEYLAKVPEVKDTVHKHSLLHHLCHMVMESSSD 2269

  Fly   871 ALNFYDDLSHVNKASRVNMDAIQKAMRQMNSAVKNLETDLQNNKVPQCDDDKFSEVMGKFAEECR 935
            ..:.|.::..:.:||:.:...:...:.|:.:..|.....|:......| .....:.:..|..:|.
  Fly  2270 TSDLYSEIGPITRASKADFTDLAHNLNQLEAECKACWDRLKLIAKHDC-PPPLKQKLVDFLADCA 2333

  Fly   936 QQVDVLGKMQLQMEKLYKDLSEYYAFD--------PSKY--TMEEFFADIKTFKDAFQAAHNDNV 990
            :::.:|..:..::...|:....:....        |:::  |:.||..:.:|.::
  Fly  2334 ERIIILQIVHRRVMNRYRKFLLWLGMPQHSVAESRPNEFCRTLSEFALEYRTTRE---------- 2388

  Fly   991 RVREELEKKRRLQEAREQSAREQQERQQRKKAVVDMDAPQTQEGVMDSLLEALQTGSAFGQRNRQ 1055
            ||:::||||          |..::..:.|.|.::||...:|::.|.|..|:.|...|:..|.:..
  Fly  2389 RVQQQLEKK----------ANHRERNKTRGKLIIDMAKFKTKDDVADDELKKLLDTSSADQADGT 2443

  Fly  1056 ARRQRPAGAERRAQLSRSRSRTRVTNGQLMTREMILNEVLGS 1097
            ...:|....:.|:.::| :|..:.|:|.        :|:|.|
  Fly  2444 LTWRRRRAEQLRSPITR-QSEEQFTDGD--------DEILES 2476

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dia	NP_001246113.1	Drf_GBD	66..248	CDD:283920	39/216 (18%)
		Drf_FH3	253..453	CDD:283917	52/303 (17%)
		FH2	608..983	CDD:280362	90/415 (22%)
Fhos	NP_001163387.2	FH2	2020..2384	CDD:280362	86/378 (23%)
Fhos	NP_001163387.2	CSRNP_N	2357..>2451	CDD:292638	24/113 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1924
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.810