DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dia and Daam2

DIOPT Version :9

Sequence 1:	NP_001246113.1	Gene:	dia / 35340	FlyBaseID:	FBgn0011202	Length:	1098	Species:	Drosophila melanogaster
Sequence 2:	XP_038940375.1	Gene:	Daam2 / 316201	RGDID:	1306128	Length:	1107	Species:	Rattus norvegicus

Alignment Length:	1124	Identity:	312/1124 - (27%)
Similarity:	534/1124 - (47%)	Gaps:	160/1124 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    64 QYIQQLS----VAELDAKFLEIIEDMNIPKDKREPLLAKSKEERQKMIMWHLKGKNSLERSANSR 124
            ||::..|    ..||:..|.|:::::::....||.:.|...|::.::.....|.:....:.|.|.
  Rat    34 QYLEFSSPIPNPEELNVCFAELVDELDLTDKNREAVFALPPEKKWQIYCSKKKEQEDPNKLATSW 98

  Fly   125 FEKPIDYVE---YLQN----GEHSTHKVYQCVESLRVALTSNPISWIKEF-GVAGIGTIEKLLAR 181
            .|..||.:.   .:||    .:..|.|..|.||.|:.||.:.|:.::..| .:.|:..:...| |
  Rat    99 PEFYIDRINAMATMQNLYDTEDEETDKRSQVVEDLKTALRTQPMRFVTRFIELEGLSCLLNFL-R 162

  Fly   182 SKNNASYE-KIEFEAIRCLKAIMNNTWG-LNVVLNPDQHSVVLLLAQSLDPRKPQTMCEALKLLA 244
            ..::|:.| :|....|.|:||:|||:.| .:|:..|:..|::   ||||.....:|....|::|.
  Rat   163 GMDHATCESRIHTSLIGCIKALMNNSQGRAHVLAQPEAISII---AQSLRTENSKTKVAVLEILG 224

  Fly   245 SFCIVYERNGYEKVLRAITTIAATSFKASERFRPIVDALFAS-----DQQDPKRDLACHSLIFIN 304
            :.|:|  ..|::|||:|:......:.:.: ||:.:::.|..|     |:.:.|..:    :.|||
  Rat   225 AVCLV--PGGHKKVLQAMLHYQVYAAERT-RFQTLLNELDRSLGRYRDEVNLKTAI----MSFIN 282

  Fly   305 TLTNT---PTDLNFRLHLRCEIMRMGLYDRLDEFTKIVEASNNENLQQHFKIFNEIREDDFEEFV 366
            .:.|.   ..:|.||||||.|.:.:|:...:|:    :....|..|.:|...|..:|.:|..|..
  Rat   283 AVLNAGAGEDNLEFRLHLRYEFLMLGIQPVIDK----LRQHENAILDKHLDFFEMVRNEDDLELA 343

  Fly   367 QRFDNVTFNMDDATDCFDVLKNLVTDTTSEPYFLSILQHLL---YIRDDFYFRPAYYQLIEECIS 428
            :|||.|..:...|:..|:::...:..|.:.|..||:|.|.|   |.|:..||:  .:||::..:.
  Rat   344 RRFDMVHIDTKSASQMFELIHKKLKHTEAYPCLLSVLHHCLQMPYKRNGGYFQ--QWQLLDRILQ 406

  Fly   429 QIVF--HKGYCDPN---FENRNF-NIDTSLLLDDIVEKAKAKESKRSEEYEKKIEQLESAKQEAE 487
            |||.  .:| .||:   .||.|. ||...|:.::.|::.:.:..|..:|:.:.:.:||..::|.|
  Rat   407 QIVLQDERG-VDPDLAPLENFNVKNIVNMLINENEVKQWRDQAEKFRKEHMELLSRLERKERECE 470

  Fly   488 AKAAHLEE--------KVKLMEANGVAAPSPNKLPKVNIPMPPPPPGGGGAPPPPPPPMPGRAGG 544
            .|....||        |.||...:.....:..::.::..|:..|||.||      |..:......
  Rat   471 TKTLEKEEMMRTLNKMKDKLARESQELRQARGQVAELTGPVSSPPPPGG------PLTLSSSTTT 529

  Fly   545 GPPPPPPPPMPGRAGGPPPPPP-PPGMGGPPPPPMPGMMRPGGGPPPPPMMMGPMVPVLPHGLKP 608
            ...||||||:|.....|||||| ||  ||||.||........|.|||...:.....|     |:.
  Rat   530 NDLPPPPPPLPLDNCTPPPPPPLPP--GGPPIPPGAPPCFSSGSPPPHEPLSSNEAP-----LRK 587

  Fly   609 KKKWDVKNPMKRANWKAIVPAKMSDKAFWVKCQEDKL--------------------------AQ 647
            |:.....:|:|..||..:...::|. ..|.:..:.::                          ||
  Rat   588 KRIPQPSHPLKSFNWVKLNEERVSG-TVWNEIDDSQVFRILDLEDFEKMFSAYQRHQGCMQEGAQ 651

  Fly   648 ---------------------DDFLAELAVK--FSSKPVKKEQKDAVDKPTTLTKKNV-DLRVLD 688
                                 :|...|.|.:  .|:..||||.....|  ..|..:.| :|.|:|
  Rat   652 RERGNVRDGGTASRSLPAAETNDHRTEKASRSMVSATGVKKELGSTED--IYLASRKVKELSVID 714

  Fly   689 SKTAQNLAIMLGGSLKHLSYEQIKICLLRCD-TDILSSNILQQLIQYLPPPEHLKRLQEIKAKGE 752
            .:.|||..|:| ..|| ||.|:|:..:||.| .:.|:.::|:||::::|....:..|:|.|.:.|
  Rat   715 GRRAQNCIILL-SKLK-LSNEEIRRAILRMDEQEDLAKDMLEQLLKFIPEKSDVDLLEEHKHEIE 777

  Fly   753 PLPPIEQFAATIGEIKRLSPRLHNLNFKLTYADMVQDIKPDIVAGTAACEEIRNSKKFSKILELI 817
            .:...::|...:..|.....||..|.||..:.:.:.:.||.:.|...|.:|:..||:..|:||::
  Rat   778 RMARADRFLYEMSRIDHYQQRLQALFFKKKFQERLAEAKPKVEAILLASQELTLSKRLKKMLEVV 842

  Fly   818 LLLGNYMNSGSKNEAAFGFEISYLTKLSNTKDA-DNKQTLLHYLADLVEKKFPDALNFYDDLSHV 881
            |.:||:||.|.:. .|:||.::.|.|:::||.: |...:|||||..::||.|||.||...:|.|:
  Rat   843 LAIGNFMNKGQRG-GAYGFRVASLNKIADTKSSIDRNISLLHYLIMILEKHFPDILNMPSELLHL 906

  Fly   882 NKASRVNMDAIQKAMRQMNSAVKNLETDLQNNKVPQCD-DDKFSEVMGKFA-------EECRQQV 938
            :||::||:..::|.:..:...::.:|.:|:..:....| :|||..||..|.       .|..:|:
  Rat   907 SKAAKVNLAELEKEVGALRRGLRAVEVELEYQRQQARDPNDKFVPVMSDFITVSSFSFSELEEQL 971

  Fly   939 DVLGKMQLQMEKLYKDLSEYYAFDPSKYTMEEFFADIKTFKDAFQAAHNDNVRVREELEKKRRLQ 1003
            :.      ..:|..|.|:.:...| ||...:|||....||..||       :..|::||..||.:
  Rat   972 NE------ARDKFAKALAHFGEQD-SKMQPDEFFGIFDTFLQAF-------LEARQDLEAMRRRK 1022

  Fly  1004 EAREQSAR--------EQQERQQRKKAVVDMDAPQTQEGVMDSLLEALQTGSAFGQRNRQARRQR 1060
            |..|:.||        .::||.||::.|: :.....:.|..|.|:.||::|..|.:...:.:|.|
  Rat  1023 EEDERRARMESMLKEQREKERWQRQRKVL-VGGALEESGEFDDLVSALRSGEVFDKDLNKFKRNR 1086

  Fly  1061 PAGAERRAQLSRSRSRTRV 1079
            .....:.|:::|.|:..|:
  Rat  1087 KRPGNQVAEVTRERAINRL 1105

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dia	NP_001246113.1	Drf_GBD	66..248	CDD:283920	51/195 (26%)
		Drf_FH3	253..453	CDD:283917	62/216 (29%)
		FH2	608..983	CDD:280362	119/434 (27%)
Daam2	XP_038940375.1	Drf_GBD	43..228	CDD:399398	50/188 (27%)
		Drf_FH3	231..435	CDD:368862	62/215 (29%)
		FH2	587..1008	CDD:396655	118/433 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1204639at2759
OrthoFinder	1	1.000	-	-		FOG0000085
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.920