Protein Alignment dia and Daam1

DIOPT Version :10

• Sequence 1: NP_001246113.1
• Gene: dia / 35340
• FlyBaseID: FBgn0011202
• Length: 1098
• Species: Drosophila melanogaster
• Sequence 2: NP_001420889.1
• Gene: Daam1 / 314212
• RGDID: 1305119
• Length: 1078
• Species: Rattus norvegicus
• Alignment Length: 1104
• Identity: 320/1104 - (28%)
• Similarity: 528/1104 - (47%)
• Gaps: 148/1104 - (13%)

  Fly    59 VEDFEQYIQQLSVAELDAKFLEIIEDMNIPKDKREPLLAKSKEERQKMIMWHL---KGKNSLERS 120
            ::..|..:....|.|||..|.|:::::::....||.:.|...|::     |.:   |.|:..|..
  Rat    38 LQTMEPALPMPPVEELDVMFSELVDELDLTDKHREAMFALPAEKK-----WQIYCSKKKDQEENK 97

  Fly   121 ANSRFEKPIDYVEYLQN----------GEHSTHKVYQCVESLRVALTSNPISWIKEF-GVAGIGT 174
            ..:.:  |..|::.|.:          .:....:..:.:|||:.||.:.|:.::..| .:.|:..
  Rat    98 GATSW--PEFYIDQLNSMAARKSLLALEKEEEEERSKTIESLKTALRTKPMRFVTRFIDLDGLSC 160

  Fly   175 IEKLLARSKNNASYEKIEFEAIRCLKAIMNNTWGLNVVLNPDQHS-VVLLLAQSLDPRKPQTMCE 238
            |...|.......|..:|....|.|:||:|||:.|...||   .|| .:.::||||.....:|...
  Rat   161 ILNFLKTMDYETSESRIHTSLIGCIKALMNNSQGRAHVL---AHSESINVIAQSLSTENIKTKVA 222

  Fly   239 ALKLLASFCIVYERNGYEKVLRAITTIAATSFKASE--RFRPIVDALFASDQQDPKRD---LACH 298
            .|::|.:.|:|  ..|::|||:|:.....   .|||  ||:.:::.|..|..:  .||   |...
  Rat   223 VLEILGAVCLV--PGGHKKVLQAMLHYQK---YASERTRFQTLINDLDKSTGR--YRDEVSLKTA 280

  Fly   299 SLIFINTLTNTPT---DLNFRLHLRCEIMRMGLYDRLDEFTKIVEASNNENLQQHFKIFNEIRED 360
            .:.|||.:.:...   .|:||||||.|.:.:|:...:|:    :....|..|.:|...|..:|.:
  Rat   281 IMSFINAVLSQGAGVESLDFRLHLRYEFLMLGIQPVIDK----LREHENSTLDRHLDFFEMLRNE 341

  Fly   361 DFEEFVQRFDNVTFNMDDATDCFDVLKNLVTDTTSEPYFLSILQHLLYIRDDFYFRPA----YYQ 421
            |..||.:||:.|..:...||..|::.:..:|.:.:.|:|:|||.|.|.:.   |.|..    |:.
  Rat   342 DELEFAKRFELVHIDTKSATQMFELTRRRLTHSEAYPHFMSILHHCLQMP---YKRSGNTVQYWL 403

  Fly   422 LIEECISQIVFH--KGYCDPN---FENRNF-NIDTSLLLDDIVEKAKAKESKRSEEYEKKIEQLE 480
            |::..|.|||..  ||. ||:   .||.|. |:...|:.::.|::.|.:..|..:|:.:..::||
  Rat   404 LLDRIIQQIVIQNDKGQ-DPDSTPLENFNIKNVVRMLVNENEVKQWKEQAEKMRKEHNELQQKLE 467

  Fly   481 SAKQEAEAKAAHLEE------KVK-----------------------LMEAN--GVAAPSPNKLP 514
            ..::|.:||....||      |:|                       |.|.|  .|.|..|.. |
  Rat   468 KKERECDAKTQEKEEMMQTLNKMKEKLEKETTEHKQVKQQVADLTAQLHELNRRAVCASVPGG-P 531

  Fly   515 KVNIPMPPPPPGG-GGAPPPPPPPMPGRAGGGPPPPPPPPMPGRAGGPPPPPPPPGMGGPPPPPM 578
            ....|..|.||.| |...||||||:   ..||..||||||:|  .|||||||.||.:||..|||
  Rat   532 SPGAPGGPFPPSGLGSLLPPPPPPL---LSGGALPPPPPPLP--PGGPPPPPGPPPLGGILPPP- 590

  Fly   579 PGMMRPGGGPPPPPMMMGPMVPVLPHGLKPKKKWDVKNPMKRANWKAIVPAKMSDKAFWVKCQED 643
                   |.|             :...||.|......|.:|..||..: |....:...|.:..:.
  Rat   591 -------GAP-------------VSLTLKKKNIPQPTNALKSFNWSKL-PENKLEGTVWTEIDDT 634

  Fly   644 KLAQDDFLAELAVKFS----------SKPVKKEQKDAVDKPTTLTKKNVDLRVLDSKTAQNLAIM 698
            |:.:...|.:|...||          :...|:::.||:|...:...|..:|.|:|.:.|||..|:
  Rat   635 KVFKILDLEDLERTFSAYQRQQEFFVNNNSKQKEADAIDDALSSKLKVKELSVIDGRRAQNCNIL 699

  Fly   699 LGGSLKHLSYEQIKICLLRCD-TDILSSNILQQLIQYLPPPEHLKRLQEIKAKGEPLPPIEQFAA 762
            |  |...||.::||..:|..| .:.|..::|:||::::|....:..|:|.|.:.:.:...::|..
  Rat   700 L--SRLKLSNDEIKRAILTMDEQEDLPKDMLEQLLKFVPEKSDIDLLEEHKHELDRMAKADRFLF 762

  Fly   763 TIGEIKRLSPRLHNLNFKLTYADMVQDIKPDIVAGTAACEEIRNSKKFSKILELILLLGNYMNSG 827
            .:..|.....||.:|.||..:|:.|.::||.:.|..::.||:..|....::||::|..|||||.|
  Rat   763 EMSRINHYQQRLQSLYFKKKFAERVAEVKPKVEAIRSSSEEVLRSSALKQLLEVVLAFGNYMNKG 827

  Fly   828 SKNEAAFGFEISYLTKLSNTKDA-DNKQTLLHYLADLVEKKFPDALNFYDDLSHVNKASRVNMDA 891
            .:.. |:||:||.|.|:::||.: |...||||||..:||.|:|..||..::|..:.:|::|||..
  Rat   828 QRGN-AYGFKISSLNKIADTKSSIDKNITLLHYLITIVENKYPKVLNLSEELRDIPQAAKVNMTE 891

  Fly   892 IQKAMRQMNSAVKNLETDL--QNNKVPQCDDDKFSEVMGKFAEECRQQVDVLGKMQLQMEKLYKD 954
            :.|.:..:.|.:|.:||:|  |.::.|| ..|||..|:.:|..........:..:..:.::|:..
  Rat   892 LDKEISTLRSGLKAVETELEYQKSQPPQ-PGDKFVSVVSQFITLASFSFSDVEDLLAEAKELFTK 955

  Fly   955 LSEYYAFDPSKYTMEEFFADIKTFKDAFQAA--HNDNVRVREELEKKRRLQEAREQSAREQQERQ 1017
            ..:::..:..|...:|||.....|..|...|  .|:|:|.|:|.|::|...||:.:..|| :||:
  Rat   956 AVKHFGEEAGKIQPDEFFGIFDQFLQAVTEAKQENENMRKRKEEEERRARLEAQLKEQRE-RERK 1019

  Fly  1018 QRKKAVVDMDAPQTQE--GVMDSLLEALQTGSAFGQRNRQARRQRPAGAERRAQLSRSRSRTRV 1079
            .||       |.::.|  |..|.|:.||::|..|.:...:.:|.|...:.:....||.|..|::
  Rat  1020 MRK-------AKESSEESGEFDDLVSALRSGEVFDKDLSKLKRNRKRISNQVTDSSRERPITKL 1076

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
dia	NP_001246113.1	Drf_GBD	66..248	CDD:461886	48/196 (24%)
		Drf_FH3	253..453	CDD:461885	66/217 (30%)
		FH2	608..983	CDD:396655	112/388 (29%)
Daam1	NP_001420889.1	Drf_GBD	45..232	CDD:461886	48/196 (24%)
		Drf_FH3	235..439	CDD:461885	66/216 (31%)
		PRK12704	444..>513	CDD:237177	13/68 (19%)
		FH2	600..983	CDD:396655	111/387 (29%)